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dbSNP Short Genetic Variations

Welcome to the Reference SNP (rs) Report

All alleles are reported in the Forward orientation. Click on the Variant Details tab for details on Genomic Placement, Gene, and Amino Acid changes. HGVS names are in the HGVS tab.

Reference SNP (rs) Report

This page reports data for a single dbSNP Reference SNP variation (RefSNP or rs) from the new redesigned dbSNP build.
Top of the page reports a concise summary for the rs, with more specific details included in the corresponding tabs below.
All alleles are reported in the Forward orientation. Use the Genomic View to inspect the nucleotides flanking the variant, and its neighbors.
For more information see Help documentation.

rs4952

Current Build 155

Released April 9, 2021

Organism
Homo sapiens
Position
chr8:42731922 (GRCh38.p13) Help

The anchor position for this RefSNP. Includes all nucleotides potentially affected by this change, thus it can differ from HGVS, which is right-shifted. See here for details.

Alleles
C>T
Variation Type
SNV Single Nucleotide Variation
Frequency
T=0.029438 (7792/264690, TOPMED)
T=0.043470 (10931/251458, GnomAD_exome)
T=0.042524 (7680/180606, ALFA) (+ 20 more)
T=0.030527 (4277/140104, GnomAD)
T=0.044850 (5445/121406, ExAC)
T=0.01788 (1407/78698, PAGE_STUDY)
T=0.03152 (410/13006, GO-ESP)
T=0.0230 (115/5008, 1000G)
T=0.0279 (125/4480, Estonian)
T=0.0420 (162/3854, ALSPAC)
T=0.0413 (153/3708, TWINSUK)
T=0.0262 (36/1374, HapMap)
T=0.031 (31/998, GoNL)
T=0.008 (6/792, PRJEB37584)
T=0.040 (24/600, NorthernSweden)
T=0.032 (17/534, MGP)
T=0.049 (15/304, FINRISK)
T=0.093 (20/216, Qatari)
T=0.05 (2/40, GENOME_DK)
C=0.50 (15/30, SGDP_PRJ)
T=0.50 (15/30, SGDP_PRJ)
C=0.5 (5/10, Siberian)
T=0.5 (5/10, Siberian)
Clinical Significance
Not Reported in ClinVar
Gene : Consequence
CHRNB3 : Synonymous Variant
Publications
11 citations
Genomic View
See rs on genome
Help

Variant Details tab shows known variant placements on genomic sequences: chromosomes (NC_), RefSeqGene, pseudogenes or genomic regions (NG_), and in a separate table: on transcripts (NM_) and protein sequences (NP_). The corresponding transcript and protein locations are listed in adjacent lines, along with molecular consequences from Sequence Ontology. When no protein placement is available, only the transcript is listed. Column "Codon[Amino acid]" shows the actual base change in the format of "Reference > Alternate" allele, including the nucleotide codon change in transcripts, and the amino acid change in proteins, respectively, allowing for known ribosomal slippage sites. To view nucleotides adjacent to the variant use the Genomic View at the bottom of the page - zoom into the sequence until the nucleotides around the variant become visible.

Genomic Placements
Sequence name Change
GRCh38.p13 chr 8 NC_000008.11:g.42731922C>T
GRCh37.p13 chr 8 NC_000008.10:g.42587065C>T
Gene: CHRNB3, cholinergic receptor nicotinic beta 3 subunit (plus strand)
Molecule type Change Amino acid[Codon] SO Term
CHRNB3 transcript variant 1 NM_000749.5:c.615C>T N [AAC] > N [AAT] Coding Sequence Variant
neuronal acetylcholine receptor subunit beta-3 isoform 1 precursor NP_000740.1:p.Asn205= N (Asn) > N (Asn) Synonymous Variant
CHRNB3 transcript variant 2 NM_001347717.2:c.393C>T N [AAC] > N [AAT] Coding Sequence Variant
neuronal acetylcholine receptor subunit beta-3 isoform 2 NP_001334646.1:p.Asn131= N (Asn) > N (Asn) Synonymous Variant
CHRNB3 transcript variant X1 XM_011544390.2:c.228C>T N [AAC] > N [AAT] Coding Sequence Variant
neuronal acetylcholine receptor subunit beta-3 isoform X1 XP_011542692.1:p.Asn76= N (Asn) > N (Asn) Synonymous Variant
Help

Clinical Significance tab shows a list of clinical significance entries from ClinVar associated with the variation, per allele. Click on the RCV accession (i.e. RCV000001615.2) or Allele ID (i.e. 12274) to access full ClinVar report.

Not Reported in ClinVar

ALFA Allele Frequency
The ALFA project provide aggregate allele frequency from dbGaP. More information is available on the project page including descriptions, data access, and terms of use.

Release Version: 20201027095038
Population Group Sample Size Ref Allele Alt Allele
Total Global 180606 C=0.957476 T=0.042524
European Sub 151778 C=0.955672 T=0.044328
African Sub 7740 C=0.9884 T=0.0116
African Others Sub 250 C=0.996 T=0.004
African American Sub 7490 C=0.9881 T=0.0119
Asian Sub 720 C=0.996 T=0.004
East Asian Sub 558 C=0.996 T=0.004
Other Asian Sub 162 C=0.994 T=0.006
Latin American 1 Sub 1106 C=0.9611 T=0.0389
Latin American 2 Sub 6348 C=0.9753 T=0.0247
South Asian Sub 190 C=0.905 T=0.095
Other Sub 12724 C=0.94962 T=0.05038


Help

Frequency tab displays a table of the reference and alternate allele frequencies reported by various studies and populations. Table lines, where Population="Global" refer to the entire study population, whereas lines, where Group="Sub", refer to a study-specific population subgroupings (i.e. AFR, CAU, etc.), if available. Frequency for the alternate allele (Alt Allele) is a ratio of samples observed-to-total, where the numerator (observed samples) is the number of chromosomes in the study with the minor allele present (found in "Sample size", where Group="Sub"), and the denominator (total samples) is the total number of all chromosomes in the study for the variant (found in "Sample size", where Group="Study-wide" and Population="Global").

Download
Study Population Group Sample Size Ref Allele Alt Allele
TopMed Global Study-wide 264690 C=0.970562 T=0.029438
gnomAD - Exomes Global Study-wide 251458 C=0.956530 T=0.043470
gnomAD - Exomes European Sub 135386 C=0.956207 T=0.043793
gnomAD - Exomes Asian Sub 49010 C=0.94619 T=0.05381
gnomAD - Exomes American Sub 34592 C=0.97525 T=0.02475
gnomAD - Exomes African Sub 16254 C=0.99046 T=0.00954
gnomAD - Exomes Ashkenazi Jewish Sub 10078 C=0.89879 T=0.10121
gnomAD - Exomes Other Sub 6138 C=0.9456 T=0.0544
Allele Frequency Aggregator Total Global 180606 C=0.957476 T=0.042524
Allele Frequency Aggregator European Sub 151778 C=0.955672 T=0.044328
Allele Frequency Aggregator Other Sub 12724 C=0.94962 T=0.05038
Allele Frequency Aggregator African Sub 7740 C=0.9884 T=0.0116
Allele Frequency Aggregator Latin American 2 Sub 6348 C=0.9753 T=0.0247
Allele Frequency Aggregator Latin American 1 Sub 1106 C=0.9611 T=0.0389
Allele Frequency Aggregator Asian Sub 720 C=0.996 T=0.004
Allele Frequency Aggregator South Asian Sub 190 C=0.905 T=0.095
gnomAD - Genomes Global Study-wide 140104 C=0.969473 T=0.030527
gnomAD - Genomes European Sub 75898 C=0.95987 T=0.04013
gnomAD - Genomes African Sub 41970 C=0.99064 T=0.00936
gnomAD - Genomes American Sub 13634 C=0.96956 T=0.03044
gnomAD - Genomes Ashkenazi Jewish Sub 3320 C=0.8928 T=0.1072
gnomAD - Genomes East Asian Sub 3132 C=0.9997 T=0.0003
gnomAD - Genomes Other Sub 2150 C=0.9693 T=0.0307
ExAC Global Study-wide 121406 C=0.955150 T=0.044850
ExAC Europe Sub 73350 C=0.95147 T=0.04853
ExAC Asian Sub 25166 C=0.94330 T=0.05670
ExAC American Sub 11578 C=0.97478 T=0.02522
ExAC African Sub 10404 C=0.99058 T=0.00942
ExAC Other Sub 908 C=0.925 T=0.075
The PAGE Study Global Study-wide 78698 C=0.98212 T=0.01788
The PAGE Study AfricanAmerican Sub 32514 C=0.98834 T=0.01166
The PAGE Study Mexican Sub 10810 C=0.97299 T=0.02701
The PAGE Study Asian Sub 8318 C=0.9992 T=0.0008
The PAGE Study PuertoRican Sub 7918 C=0.9765 T=0.0235
The PAGE Study NativeHawaiian Sub 4534 C=0.9868 T=0.0132
The PAGE Study Cuban Sub 4228 C=0.9605 T=0.0395
The PAGE Study Dominican Sub 3828 C=0.9684 T=0.0316
The PAGE Study CentralAmerican Sub 2450 C=0.9800 T=0.0200
The PAGE Study SouthAmerican Sub 1982 C=0.9798 T=0.0202
The PAGE Study NativeAmerican Sub 1260 C=0.9738 T=0.0262
The PAGE Study SouthAsian Sub 856 C=0.915 T=0.085
GO Exome Sequencing Project Global Study-wide 13006 C=0.96848 T=0.03152
GO Exome Sequencing Project European American Sub 8600 C=0.9590 T=0.0410
GO Exome Sequencing Project African American Sub 4406 C=0.9871 T=0.0129
1000Genomes Global Study-wide 5008 C=0.9770 T=0.0230
1000Genomes African Sub 1322 C=0.9939 T=0.0061
1000Genomes East Asian Sub 1008 C=0.9980 T=0.0020
1000Genomes Europe Sub 1006 C=0.9642 T=0.0358
1000Genomes South Asian Sub 978 C=0.944 T=0.056
1000Genomes American Sub 694 C=0.980 T=0.020
Genetic variation in the Estonian population Estonian Study-wide 4480 C=0.9721 T=0.0279
The Avon Longitudinal Study of Parents and Children PARENT AND CHILD COHORT Study-wide 3854 C=0.9580 T=0.0420
UK 10K study - Twins TWIN COHORT Study-wide 3708 C=0.9587 T=0.0413
HapMap Global Study-wide 1374 C=0.9738 T=0.0262
HapMap American Sub 600 C=0.972 T=0.028
HapMap African Sub 510 C=0.984 T=0.016
HapMap Europe Sub 176 C=0.938 T=0.062
HapMap Asian Sub 88 C=1.00 T=0.00
Genome of the Netherlands Release 5 Genome of the Netherlands Study-wide 998 C=0.969 T=0.031
CNV burdens in cranial meningiomas Global Study-wide 792 C=0.992 T=0.008
CNV burdens in cranial meningiomas CRM Sub 792 C=0.992 T=0.008
Northern Sweden ACPOP Study-wide 600 C=0.960 T=0.040
Medical Genome Project healthy controls from Spanish population Spanish controls Study-wide 534 C=0.968 T=0.032
FINRISK Finnish from FINRISK project Study-wide 304 C=0.951 T=0.049
Qatari Global Study-wide 216 C=0.907 T=0.093
The Danish reference pan genome Danish Study-wide 40 C=0.95 T=0.05
SGDP_PRJ Global Study-wide 30 C=0.50 T=0.50
Siberian Global Study-wide 10 C=0.5 T=0.5
Help

Aliases tab displays HGVS names representing the variant placements and allele changes on genomic, transcript and protein sequences, per allele. HGVS name is an expression for reporting sequence accession and version, sequence type, position, and allele change. The column "Note" can have two values: "diff" means that there is a difference between the reference allele (variation interval) at the placement reported in HGVS name and the reference alleles reported in other HGVS names, and "rev" means that the sequence of this variation interval at the placement reported in HGVS name is in reverse orientation to the sequence(s) of this variation in other HGVS names not labeled as "rev".

Placement C= T
GRCh38.p13 chr 8 NC_000008.11:g.42731922= NC_000008.11:g.42731922C>T
GRCh37.p13 chr 8 NC_000008.10:g.42587065= NC_000008.10:g.42587065C>T
CHRNB3 transcript variant 1 NM_000749.5:c.615= NM_000749.5:c.615C>T
CHRNB3 transcript variant 1 NM_000749.4:c.615= NM_000749.4:c.615C>T
CHRNB3 transcript NM_000749.3:c.615= NM_000749.3:c.615C>T
CHRNB3 transcript variant 2 NM_001347717.2:c.393= NM_001347717.2:c.393C>T
CHRNB3 transcript variant 2 NM_001347717.1:c.393= NM_001347717.1:c.393C>T
CHRNB3 transcript variant X1 XM_011544390.2:c.228= XM_011544390.2:c.228C>T
neuronal acetylcholine receptor subunit beta-3 isoform 1 precursor NP_000740.1:p.Asn205= NP_000740.1:p.Asn205=
neuronal acetylcholine receptor subunit beta-3 isoform 2 NP_001334646.1:p.Asn131= NP_001334646.1:p.Asn131=
neuronal acetylcholine receptor subunit beta-3 isoform X1 XP_011542692.1:p.Asn76= XP_011542692.1:p.Asn76=
Help

Submissions tab displays variations originally submitted to dbSNP, now supporting this RefSNP cluster (rs). We display Submitter handle, Submission identifier, Date and Build number, when the submission appeared for the first time. Direct submissions to dbSNP have Submission ID in the form of an ss-prefixed number (ss#). Other supporting variations are listed in the table without ss#.

88 SubSNP, 21 Frequency submissions
No Submitter Submission ID Date (Build)
1 NYEP ss6384 Sep 19, 2000 (52)
2 LEE ss1528374 Oct 13, 2000 (92)
3 CSHL-HAPMAP ss68404361 Jan 12, 2007 (127)
4 ILLUMINA ss75137069 Dec 07, 2007 (129)
5 UUGC ss76901675 Dec 07, 2007 (129)
6 BCMHGSC_JDW ss93876502 Mar 25, 2008 (129)
7 KRIBB_YJKIM ss119337491 Dec 01, 2009 (131)
8 ENSEMBL ss143421643 Dec 01, 2009 (131)
9 ILLUMINA ss160731740 Dec 01, 2009 (131)
10 PERLEGEN ss161151692 Dec 01, 2009 (131)
11 ILLUMINA ss173888650 Jul 04, 2010 (132)
12 1000GENOMES ss234416088 Jul 15, 2010 (132)
13 NHLBI-ESP ss342258041 May 09, 2011 (134)
14 ILLUMINA ss481113018 May 04, 2012 (137)
15 ILLUMINA ss481135016 May 04, 2012 (137)
16 ILLUMINA ss482124907 Sep 08, 2015 (146)
17 ILLUMINA ss485351569 May 04, 2012 (137)
18 1000GENOMES ss490964544 May 04, 2012 (137)
19 CLINSEQ_SNP ss491924631 May 04, 2012 (137)
20 ILLUMINA ss537298042 Sep 08, 2015 (146)
21 ILLUMINA ss778554264 Sep 08, 2015 (146)
22 ILLUMINA ss783121511 Sep 08, 2015 (146)
23 ILLUMINA ss784078275 Sep 08, 2015 (146)
24 ILLUMINA ss832380297 Sep 08, 2015 (146)
25 ILLUMINA ss834011034 Sep 08, 2015 (146)
26 EVA-GONL ss985447332 Aug 21, 2014 (142)
27 JMKIDD_LAB ss1067497455 Aug 21, 2014 (142)
28 1000GENOMES ss1329585315 Aug 21, 2014 (142)
29 EVA_GENOME_DK ss1582661025 Apr 01, 2015 (144)
30 EVA_FINRISK ss1584058315 Apr 01, 2015 (144)
31 EVA_DECODE ss1595044915 Apr 01, 2015 (144)
32 EVA_UK10K_ALSPAC ss1620494789 Apr 01, 2015 (144)
33 EVA_UK10K_TWINSUK ss1663488822 Apr 01, 2015 (144)
34 EVA_EXAC ss1689184669 Apr 01, 2015 (144)
35 EVA_MGP ss1711199968 Apr 01, 2015 (144)
36 EVA_SVP ss1713033114 Apr 01, 2015 (144)
37 ILLUMINA ss1752732676 Sep 08, 2015 (146)
38 WEILL_CORNELL_DGM ss1928736673 Feb 12, 2016 (147)
39 ILLUMINA ss1959106924 Feb 12, 2016 (147)
40 JJLAB ss2025071281 Sep 14, 2016 (149)
41 USC_VALOUEV ss2153293742 Dec 20, 2016 (150)
42 HUMAN_LONGEVITY ss2302697630 Dec 20, 2016 (150)
43 TOPMED ss2472354659 Dec 20, 2016 (150)
44 ILLUMINA ss2634741462 Nov 08, 2017 (151)
45 GNOMAD ss2737136472 Nov 08, 2017 (151)
46 GNOMAD ss2748042481 Nov 08, 2017 (151)
47 GNOMAD ss2865988886 Nov 08, 2017 (151)
48 AFFY ss2986081522 Nov 08, 2017 (151)
49 SWEGEN ss3003068838 Nov 08, 2017 (151)
50 ILLUMINA ss3022841309 Nov 08, 2017 (151)
51 CSHL ss3348155034 Nov 08, 2017 (151)
52 TOPMED ss3560232376 Nov 08, 2017 (151)
53 ILLUMINA ss3630049846 Oct 12, 2018 (152)
54 ILLUMINA ss3632640797 Oct 12, 2018 (152)
55 ILLUMINA ss3633499202 Oct 12, 2018 (152)
56 ILLUMINA ss3634225926 Oct 12, 2018 (152)
57 ILLUMINA ss3635169793 Oct 12, 2018 (152)
58 ILLUMINA ss3635904758 Oct 12, 2018 (152)
59 ILLUMINA ss3636907172 Oct 12, 2018 (152)
60 ILLUMINA ss3637657926 Oct 12, 2018 (152)
61 ILLUMINA ss3638757522 Oct 12, 2018 (152)
62 ILLUMINA ss3640877083 Oct 12, 2018 (152)
63 ILLUMINA ss3643688569 Oct 12, 2018 (152)
64 OMUKHERJEE_ADBS ss3646374984 Oct 12, 2018 (152)
65 ILLUMINA ss3653382985 Oct 12, 2018 (152)
66 EGCUT_WGS ss3670763226 Jul 13, 2019 (153)
67 EVA_DECODE ss3721891775 Jul 13, 2019 (153)
68 ILLUMINA ss3726534006 Jul 13, 2019 (153)
69 ACPOP ss3735611275 Jul 13, 2019 (153)
70 ILLUMINA ss3745469666 Jul 13, 2019 (153)
71 EVA ss3767922754 Jul 13, 2019 (153)
72 PAGE_CC ss3771439500 Jul 13, 2019 (153)
73 ILLUMINA ss3772962117 Jul 13, 2019 (153)
74 PACBIO ss3786130731 Jul 13, 2019 (153)
75 PACBIO ss3791389856 Jul 13, 2019 (153)
76 PACBIO ss3796271147 Jul 13, 2019 (153)
77 KHV_HUMAN_GENOMES ss3811083282 Jul 13, 2019 (153)
78 EVA ss3824367525 Apr 26, 2020 (154)
79 EVA ss3825740626 Apr 26, 2020 (154)
80 EVA ss3831137767 Apr 26, 2020 (154)
81 SGDP_PRJ ss3869788497 Apr 26, 2020 (154)
82 FSA-LAB ss3984398584 Apr 26, 2021 (155)
83 EVA ss3984604749 Apr 26, 2021 (155)
84 EVA ss3986422241 Apr 26, 2021 (155)
85 EVA ss4017388039 Apr 26, 2021 (155)
86 TOPMED ss4783798456 Apr 26, 2021 (155)
87 EVA ss5237042449 Apr 26, 2021 (155)
88 EVA ss5237441110 Apr 26, 2021 (155)
89 1000Genomes NC_000008.10 - 42587065 Oct 12, 2018 (152)
90 The Avon Longitudinal Study of Parents and Children NC_000008.10 - 42587065 Oct 12, 2018 (152)
91 Genetic variation in the Estonian population NC_000008.10 - 42587065 Oct 12, 2018 (152)
92 ExAC NC_000008.10 - 42587065 Oct 12, 2018 (152)
93 FINRISK NC_000008.10 - 42587065 Apr 26, 2020 (154)
94 The Danish reference pan genome NC_000008.10 - 42587065 Apr 26, 2020 (154)
95 gnomAD - Genomes NC_000008.11 - 42731922 Apr 26, 2021 (155)
96 gnomAD - Exomes NC_000008.10 - 42587065 Jul 13, 2019 (153)
97 GO Exome Sequencing Project NC_000008.10 - 42587065 Oct 12, 2018 (152)
98 Genome of the Netherlands Release 5 NC_000008.10 - 42587065 Apr 26, 2020 (154)
99 HapMap NC_000008.11 - 42731922 Apr 26, 2020 (154)
100 Medical Genome Project healthy controls from Spanish population NC_000008.10 - 42587065 Apr 26, 2020 (154)
101 Northern Sweden NC_000008.10 - 42587065 Jul 13, 2019 (153)
102 The PAGE Study NC_000008.11 - 42731922 Jul 13, 2019 (153)
103 CNV burdens in cranial meningiomas NC_000008.10 - 42587065 Apr 26, 2021 (155)
104 Qatari NC_000008.10 - 42587065 Apr 26, 2020 (154)
105 SGDP_PRJ NC_000008.10 - 42587065 Apr 26, 2020 (154)
106 Siberian NC_000008.10 - 42587065 Apr 26, 2020 (154)
107 TopMed NC_000008.11 - 42731922 Apr 26, 2021 (155)
108 UK 10K study - Twins NC_000008.10 - 42587065 Oct 12, 2018 (152)
109 ALFA NC_000008.11 - 42731922 Apr 26, 2021 (155)
Help

History tab displays RefSNPs (Associated ID) from previous builds (Build) that now support the current RefSNP, and the dates, when the history was updated for each Associated ID (History Updated).

Associated ID History Updated (Build)
rs1132126 Jan 18, 2001 (92)
Added to this RefSNP Cluster:
Submission IDs Observation SPDI Canonical SPDI Source RSIDs
ss93876502, ss481113018, ss491924631, ss1595044915, ss1713033114, ss3643688569 NC_000008.9:42706221:C:T NC_000008.11:42731921:C:T (self)
41702286, 23192463, 16501474, 9283752, 54776, 8825963, 6307991, 825372, 10357149, 315728, 8896140, 154187, 10778603, 21805477, 5810096, 23192463, ss234416088, ss342258041, ss481135016, ss482124907, ss485351569, ss490964544, ss537298042, ss778554264, ss783121511, ss784078275, ss832380297, ss834011034, ss985447332, ss1067497455, ss1329585315, ss1582661025, ss1584058315, ss1620494789, ss1663488822, ss1689184669, ss1711199968, ss1752732676, ss1928736673, ss1959106924, ss2025071281, ss2153293742, ss2472354659, ss2634741462, ss2737136472, ss2748042481, ss2865988886, ss2986081522, ss3003068838, ss3022841309, ss3348155034, ss3630049846, ss3632640797, ss3633499202, ss3634225926, ss3635169793, ss3635904758, ss3636907172, ss3637657926, ss3638757522, ss3640877083, ss3646374984, ss3653382985, ss3670763226, ss3735611275, ss3745469666, ss3767922754, ss3772962117, ss3786130731, ss3791389856, ss3796271147, ss3824367525, ss3825740626, ss3831137767, ss3869788497, ss3984398584, ss3984604749, ss3986422241, ss4017388039, ss5237441110 NC_000008.10:42587064:C:T NC_000008.11:42731921:C:T (self)
294044408, 3613823, 660969, 388195122, 621176016, 1723561351, ss2302697630, ss3560232376, ss3721891775, ss3726534006, ss3771439500, ss3811083282, ss4783798456, ss5237042449 NC_000008.11:42731921:C:T NC_000008.11:42731921:C:T (self)
ss6384, ss1528374, ss68404361, ss75137069, ss76901675, ss119337491, ss143421643, ss160731740, ss161151692, ss173888650 NT_167187.1:30445210:C:T NC_000008.11:42731921:C:T (self)
Help

Publications tab displays PubMed articles citing the variation as a listing of PMID, Title, Author, Year, Journal, ordered by Year, descending.

11 citations for rs4952
PMID Title Author Year Journal
17135278 Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs. Saccone SF et al. 2007 Human molecular genetics
18571741 Genetic variability in nicotinic acetylcholine receptors and nicotine addiction: converging evidence from human and animal research. Portugal GS et al. 2008 Behavioural brain research
19029397 Nicotinic receptor gene variants influence susceptibility to heavy smoking. Stevens VL et al. 2008 Cancer epidemiology, biomarkers & prevention
19760673 Association of CHRN genes with "dizziness" to tobacco. Ehringer MA et al. 2010 American journal of medical genetics. Part B, Neuropsychiatric genetics
20418888 Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior. Thorgeirsson TE et al. 2010 Nature genetics
20584212 Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans. Saccone NL et al. 2010 Genes, brain, and behavior
21191315 Genetic association of bipolar disorder with the β(3) nicotinic receptor subunit gene. Hartz SM et al. 2011 Psychiatric genetics
24401102 Multiple distinct CHRNB3-CHRNA6 variants are genetic risk factors for nicotine dependence in African Americans and European Americans. Culverhouse RC et al. 2014 Addiction (Abingdon, England)
25036316 Joint association of nicotinic acetylcholine receptor variants with abdominal obesity in American Indians: the Strong Heart Family Study. Zhu Y et al. 2014 PloS one
27327258 Crucial roles of the CHRNB3-CHRNA6 gene cluster on chromosome 8 in nicotine dependence: update and subjects for future research. Wen L et al. 2016 Translational psychiatry
27827986 Replicated Risk Nicotinic Cholinergic Receptor Genes for Nicotine Dependence. Zuo L et al. 2016 Genes
Help

The Flanks tab provides retrieving flanking sequences of a SNP on all molecules that have placements.

Genome context:
Select flank length:

Genomic regions, transcripts, and products
Top Help

NCBI Graphical Sequence Viewer display of the genomic region, transcripts and protein products for the reported RefSNP (rs).
Use the zoom option to view the nucleotides around the RefSNP and find other neighboring RefSNPs.
Visit Sequence Viewer for help with navigating inside the display and modifying the selection of displayed data tracks.

Software version is: 2.0.1.post596+ae089ad