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ERX9264488: HiSeq X Ten paired end sequencing
1 ILLUMINA (HiSeq X Ten) run: 56.2M spots, 17G bases, 6.4Gb downloads

Submitted by: Centre for Palaeogenetics
Study: Genome deletions and insertions contributed to adaptations in the woolly mammoth
show Abstracthide Abstract
Woolly mammoths had a set of unique adaptations that enabled them to thrive in the extreme Arctic environment. To date, a large set of mammoth-specific, protein-changing single nucleotide polymorphisms (SNPs) have been identified using ancient genomes. Although these SNPs are responsible for many mammoth traits, a multitude of other genetic variants likely contributed to the evolution of the woolly mammoth. In this study we sequenced two woolly mammoth genomes to high coverage and combined these with published high-coverage mammoth and elephant genomes to conduct a broad survey of mammoth-specific large deletions and shorter insertions and deletions. We find that deletions and indels are highly enriched in non-coding regions, suggesting strong selection against structural variants that affect protein sequences. Nonetheless, we find that at least 87 woolly mammoth genes are affected by deletions or indels in the mammoth lineage, including genes involved in skeletal morphology, body size, hair growth, body-fat distribution and behaviour. These results suggest that deletions and indels likely had an important role in the unique phenotypic adaptations of the woolly mammoth, and thus, need to be considered for de-extinction of this species through genetic engineering.
Sample: woolly mammoth
SAMEA14372188 • ERS11966670 • All experiments • All runs
Library:
Name: NA
Instrument: HiSeq X Ten
Strategy: WGS
Source: GENOMIC
Selection: RANDOM
Layout: PAIRED
Runs: 1 run, 56.2M spots, 17G bases, 6.4Gb
Run# of Spots# of BasesSizePublished
ERR971524756,187,34417G6.4Gb2022-07-15

ID:
22986689

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