show Abstracthide AbstractTick salivary constituents antagonize inflammatory, immune and hemostatic host responses, favoring the tick blood feeding and the establishment of tick-borne pathogens on hosts during hematophagy. Amblyomma cajennense is important in veterinary and human health, because it is a vector of etiological agents for several diseases. Insights into the tick salivary components involved in blood feeding are essential to understand vector-pathogen-host interactions and assessing the transcriptional profiling of salivary glands is a powerful tool to do so. Here, we disclosed the sialotranscriptome of Amblyomma cajennense under a functional perspective, allowing a comparison among them as well as with other hematophagous arthropod species.