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| Status |
Public on Oct 25, 2010 |
| Title |
Building Prognostic Models for Breast Cancer Patients Using Clinical Variables and Gene Expression Signatures |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Our findings indicate that the integration of expression signatures and clinicopathological factors can better determine the individual risk of recurrence for newly diagnosed patients with lymph-node negative ER-positive breast cancer. Models incorporating other variables yet to be discovered will be needed to obtain robust prognostic models for ER-negative and HER2-positive breast cancer patients.
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| Overall design |
A large data set was created by combining five different publicly available microarray datasets of node-negative breast cancer patients treated with local therapy only. The microarray gene expression data was combined using the batch effect adjustment by the Distance Weighted Discrimination method.
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| Contributor(s) |
FAN C, Prat Aparicio A, Parker JS, Liu Y, Perou CM |
| Citation(s) |
21214954 |
| Submission date |
Mar 25, 2009 |
| Last update date |
Feb 20, 2017 |
| Contact name |
Charles M. Perou |
| E-mail(s) |
cperou@med.unc.edu
|
| Organization name |
University of North Carolina at Chapel Hill
|
| Department |
Professor of Genetics, and Pathology & Laboratory Medicine; Lineberger Comprehensive Cancer Center
|
| Street address |
12-044 Lineberger Comprehensive Cancer Center CB# 7295
|
| City |
Chapel Hill |
| State/province |
NC |
| ZIP/Postal code |
27599-7264 |
| Country |
USA |
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| Platforms (4)
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| GPL885 |
Agilent-011521 Human 1A Microarray G4110A (Feature Number version) |
| GPL887 |
Agilent-012097 Human 1A Microarray (V2) G4110B (Feature Number version) |
| GPL1390 |
Agilent Human 1A Oligo UNC custom Microarrays |
| GPL5325 |
Agilent UNC Perou Lab Homo sapiens 1X44K Custom Array |
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| Samples (42)
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| Relations |
| BioProject |
PRJNA117131 |
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