|
| Status |
Public on Feb 22, 2011 |
| Title |
MicroRNA expression contributes to the poor prognosis of human small cell lung cancer |
| Platform organisms |
Homo sapiens; Mus musculus; Rattus norvegicus |
| Sample organism |
Homo sapiens |
| Experiment type |
Non-coding RNA profiling by array
|
| Summary |
MicroRNAs are important cellular components and their dysfunctions are associated with various disease.Small-cell lung cancer (SCLC) is an aggressive disease with a poor prognosis, but little is know about the underlying machinery that leads to rapid tumor growth and early metastases.In this study, clinical outcome prediction miRNAs were successfully found through expression profiling of a total of 924 miRNA genes in 42 SCLC cases.
|
| |
|
| Overall design |
42 patients with respectable very limited disease (training set) were enrolled. All the patients underwent surgical resection followed by adjuvant chemotherapy according to the standard of care. Total RNA was extracted from formalin-fixed paraffin-embedded （FFPE）specimens, low molecular weight RNA was seperate and labeled , and then hybridized to capitalbio V3 biochip representing about 924 microRNA . three chip were test in each group, and the procedure was repeated twice.
|
| |
|
| Contributor(s) |
Cao J, Song Y, Bi N, Wang L, Zhan Q |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Feb 22, 2011 |
| Last update date |
Mar 23, 2012 |
| Contact name |
nan bi |
| E-mail(s) |
binan.email@gmail.com
|
| Organization name |
Cancer Hospital and Cancer Institute
|
| Street address |
Panjiayuannanli 17#
|
| City |
Beijing |
| ZIP/Postal code |
100021 |
| Country |
China |
| |
|
| Platforms (1) |
| GPL8469 |
Capitalbio mammal microRNA V3.0 |
|
| Samples (42)
|
|
| Relations |
| BioProject |
PRJNA137081 |
Less...
More...