2FO1


Conserved Protein Domain Family
LAG1-DNAbind
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pfam09271: LAG1-DNAbind 
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LAG1, DNA binding
Members of this family are found in various eukaryotic hypothetical proteins and in the DNA-binding protein LAG-1. They adopt a beta sandwich structure, with nine strands in two beta-sheets, in a Greek-key topology, and allow for DNA binding. This domain is also known as RHR-N (Rel-homology region) as it related to Rel domain proteins.
Links
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Statistics
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PSSM-Id: 462735
Aligned: 47 rows
Threshold Bit Score: 96.9974
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2FO1_A         31 ISIFHAKVAQKSYGNEKRFFCPPPCIYLIGQgwklkkdrvaqlyk----------------------------------- 75   Caenorhabditi...
XP_006956985  177 ISISTPQTAQKSYGNEKRFIAPPPQVCLIGKnwnsenkkggqshalaldlgqlspsvqvklgnglqahdcelkwsqftes 256 
Q5KPQ7        116 LEVWHPTTGQKSYGKERRMLNPPPILRLSGP------------------------------------------------- 146  Cryptococcus ...
EMR10155      401 IIIYTSKVAQKSYGTEKRYLCPPPCLRLLGSkwfegcla----------------------------------------- 439 
XP_018229012  379 VMIYTSKVAQKSYGTEKRYLCPPPYLRLLGAkwfesylqdv--------------------------------------- 419 
O74412        473 FYLCMPSLCQKSYGTERRYLCPPIVLYLLGTtwlnnvtdnlkisaqtl-------------------------------- 520  Schizosacchar...
XP_011392222  379 IRCSHASVAQKSYGSEKRFFNPPPIISITGPlrryaehg----------------------------------------- 417 
CCF51629      368 IRCAHASVAQKSYGSEKRFFNPPPIISVTGPlrryaehg----------------------------------------- 406 
GAC72297      358 VRCAHASVAQKSYGSEKRFFNPPPIISVTGPlrryaehg----------------------------------------- 396 
GAC98902      369 IRCSHASVAQKSYGSEKRFFNPPPIISVTGPlrryaehg----------------------------------------- 407 

2FO1_A         76 ----tlkasaqkdaaienDPIHEQQATELVAYIG-IGS-DTSERQQLDFstgkvrhpg--------------dqrqdpni 135  Caenorhabditi...
XP_006956985  257 qskqsnlpltppdsspnsNKSDYVEESNDTNQMTmLGK------------------------------------------ 294 
Q5KPQ7        147 -------------------------ASSCISSITmVSVvSPNITQPVAI------------------------------- 170  Cryptococcus ...
EMR10155      440 -----------diplnsfPGTNQKENTYGTNVFG-MYSfMDIYATSLLLdveesfnissmdcycsdgtifkpgsskttpv 507 
XP_018229012  420 ---------htiesmfsrTGQNEHPYSIDLGSRG-LEAfMDIHVTSLLLdveesfsvssmdcycsdgsvfrpglgkalpv 489 
O74412        521 --edkdnpkfaknifyynADGALISPETDIAKSTyQLTnYNENTNFDSFp-----------------------------v 569  Schizosacchar...
XP_011392222  418 ----------aatlltplSSEDP-EEDQCRVSLVvRGDtDEYFSNENVAv-----------------------------l 457 
CCF51629      407 ----------aatlttssTSEDADEEDQCRVSLLvRGDtDEFYSNENVAv-----------------------------l 447 
GAC72297      397 ----------aatlttssTSEDADEEEQCRVSLLvRGDtDEFFSNENVAv-----------------------------l 437 
GAC98902      408 ----------aavlhtsqTAEDADEEDQCRVSLLvRGDtDEFYSNENVAv-----------------------------l 448 

2FO1_A        136 YDY--CAAKTLY---------------IS-DSD-KRKYFDLNAQFFYGC----------------GME------------ 168  Caenorhabditi...
XP_006956985  295 -----ALARHLH---------------IT-DVAdDRKITNCYAEVVIPSllsr--------------------------- 326 
Q5KPQ7        171 -----CAPQTHHmgrppditphlgtpgVE-DKKkERREEQKKLRTAALN------------------------------- 213  Cryptococcus ...
EMR10155      508 WGK--INLRSMY---------------VP-DRKeKIRSACLKVQLHKKNke----------------------------- 540 
XP_018229012  490 WGK--THLRTMY---------------IS-DRKeKIRSTCLKVQLHRKNkes---------------------------- 523 
O74412        570 WGN--ALLKTIY---------------YTgQGKnDGFGRSTFLQLSVQS----------------KTK------------ 604  Schizosacchar...
XP_011392222  458 DGRleTKMRSLY---------------VT-PTG-RSKSFRLQLNLLRPSglephlpifsplkksrAADalspamsigspa 520 
CCF51629      448 DSQleTKMRSLY---------------VT-PTG-RSKSFRLQLNLLRPSglephlpifsplkksrTADalspamsvgspa 510 
GAC72297      438 DQTleAKMRSLY---------------VT-PTG-RSKAFRLQLNLLRPSglephlpifsplkksrAADplspaisagspa 500 
GAC98902      449 DSRleTKMRSLY---------------VT-PTG-RSKAFRLQLNLLRPSglephlpifsplkksrASEavspaistespa 511 

2FO1_A        169 -------------------IGGFVSQRIKVISKPSKKKQSMKNTD 194  Caenorhabditis elegans
XP_006956985  327 ----------------npfKGSFALPNMNIISKASKQRKPKRNEE 355 
Q5KPQ7        214 -------------------AGFAATLPKNRNATDLKDRTLLKDGL 239  Cryptococcus neoformans
EMR10155      541 -----------------fnFVQFQSSPICIISKASQKKTSSKNND 568 
XP_018229012  524 -----------------fnFAQFQSSPICIISKAPQKKTSSKNND 551 
O74412        605 -------------------YFKLENLRLGVISKPSQKRALMKVSD 630  Schizosaccharomyces pombe 972h-
XP_011392222  521 nepiengsevlsrlpkelaWASFESAPVTIISKSSKKTAKPRGEL 565 
CCF51629      511 gdqadtsseplsrlpkglaWASFESAPVTIISKSSKKTAKPRGQT 555 
GAC72297      501 ydqadsgsetlsrlpkglaWASFESAPVTIISKSSKKTAKPRGQI 545 
GAC98902      512 neqtdagsevlsrlpkglaWASFESAPVAIISKSSKKTAKPRGQT 556
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