Conserved Protein Domain Family
half-pint

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TIGR01645: half-pint 
poly-U binding splicing factor, half-pint family
The proteins represented by this model contain three RNA recognition motifs (rrm: pfam00076) and have been characterized as poly-pyrimidine tract binding proteins associated with RNA splicing factors. In the case of PUF60 (GP|6176532), in complex with p54, and in the presence of U2AF, facilitates association of U2 snRNP with pre-mRNA.
Statistics
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PSSM-Id: 130706
View PSSM: TIGR01645
Aligned: 3 rows
Threshold Bit Score: 822.779
Threshold Setting Gi: 6684440
Created: 8-Oct-2014
Updated: 23-Jan-2015
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6684440    7 ALQVNGQQGGGSEPAAAAAVVAAG---DKWKP--------PQGTDSIKMENG-QSTAAK--LGL--PPLTPEQQEALQKA 70
gi 24655228  10 SPRSDDQREISDMPATKRTRSDSGkstDSKIPylsqplydLKQTGDVKFGPG-TRSALLglLGGalPKLSSEQHDLVSKA 88
gi 17510025   5 SADIENRPVAAFRPAVSVPMPVLP------------------QDGEVFVGPGgKKDAQKigLGL--SKLSSKRKDDIQMA 64
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6684440   71 KKyAMEQSIKSVLVKQTIAHQQQQLTNLQMAavtmgfgdplsplqsmaAQRQRALAIMCRVyVGSIYYELGEDTIRQAFA 150
gi 24655228  89 KKyAMEQSIKMVLMKQTLAHQQQQLATQRTQ-----------------VQRQQALALMCRVyVGSISFELKEDTIRVAFT 151
gi 17510025  65 KKyAMDISIKQILLRQQKQ----QQENQQRQ-----------------QMYSQALSIMSRIyVGSISFEIREDMLRRAFD 123
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6684440  151 PFGPIKSIDMSWDSVTMKHKGFAFVEyEVPEAAQLALEQMNSVMLGGRNIKVG--------RPSNIGQAQPIIDQLAEEA 222
gi 24655228 152 PFGPIKSINMSWDPITQKHKGFAFVEyEIPEGAQLALEQMNGALMGGRNIKVG--------RPSNMPQAQQVIDEVQEEA 223
gi 17510025 124 PFGPIKSINMSWDPATGHHKTFAFVEyEVPEAALLAQESMNGQMLGGRNLKVNsmmfqemrLPQNMPQAQPIIDMVQKDA 203
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6684440  223 RAFNRIyVASVHQDLSDDDIKSVFEAFGKIKSCTLARDPTTGKHKGYGFIEYEKAQSSQDAVSSMNLFDLGGQYLRVGKA 302
gi 24655228 224 KSFNRIyVASIHPDLSEEDIKSVFEAFGPILYCKLAQGTSLHTHKGYGFIEYANKQAMDEAIASMNLFDLGGQLLRVGRS 303
gi 17510025 204 KKYFRVyVSSVHPDLSETDLKSVFEAFGEIVKCQLARAPTGRGHRGFGYLEFNNLTSQSEAIAGMNMFDLGGQYLRVGKC 283
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6684440  303 VTPPMPL--LTPATPGGLPPAAAVAAAAATAKITAQEAVAG-------------AAVLG---------------TLGTPG 352
gi 24655228 304 ITPPNAL--ACPTTNSTMPTAAAVAAAAATAKIQALDAVAS-------------NAVLGlsqntpvmaagavvtKVGAMP 368
gi 17510025 284 VTPPDALtyLQPASVSAIPASVSVACAAITAKVMAAEAAAGsspktpsesggsrAASPApraqspatpssslptDIENKA 363
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6684440  353 LVSPALTLAQ--PLGTLPQAVMAAQAPGVITG------------VTP---ARP---PIPVTIPSVGVVNP---------- 402
gi 24655228 369 VVSAATSAAA--LHPALAQAAPALLPPGIFQA------------PTP---VAPsllGVPAGLQPLQAVVPtlp-----pp 426
gi 17510025 364 VISSPKKEPEeiEVPPLPPSAPDVVKDEPMEIeeeeeytipeekPKPvaiVPPpglAIPSLVAPPGLIAPteigivvpnp 443
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6684440  403 -ILA-------------------------SP-------------------------------------------PTLGLL 413
gi 24655228 427 aLLA-------------------------TPtlpmtvggv--------------------------gvglvptvATLAGA 455
gi 17510025 444 sFLAqqqqkieekieeeeeartervklstSQrkkmkreklnqmtfeekmaqvlgqqkavqnqrmadpvtfgaldDTVAWK 523
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6684440  414 EPKK-------------------------------------------------------------EKEEEELFP------ 426
gi 24655228 456 EASKgaaaaaalsaaanna-------------------------------avtaanlsenikkahEKQQEELQKkl---- 500
gi 17510025 524 DPSNedqtsedgkmlaimgpgrggdnvasmalalmdggsslmlannakakeaaaalalepkkkkkVKEGKKIQPklntaq 603
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6684440  427 -------------------ESERPEMLSEQEHMSISGSSARHMVMQKLLRKQESTVMVLRNMVDPKDIDDDLEGEVTEEC 487
gi 24655228 501 ------------------mDEGDVQTLQQQENMSIKGQSARQLVMQRLMRPVDSRVIILRNMVGPEDVDETLQEEIQEEC 562
gi 17510025 604 alaaaakagemsdalknevMNSEDASLASQEGLEIRGNDARHLLMTKLMRTNRSNVIVLRNMVTPQDIDEFLEGEIREEC 683
                       730       740       750       760       770       780       790
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6684440  488 GK-FGAVNRVIIYQEKQGEEED---AEIIVKIFVEFSIASETHKAIQALNGRWFAGRKVVAEVyDQERFDNSDLSA 559
gi 24655228 563 SK-FGTVSRVIIFNEKQTENEDddeAEIIVKIFVEFSAGAEAMRGKEALDGRFFGGRRVVAELyDQGIFDQGDLSG 637
gi 17510025 684 GKyGNVIDVVIANFASSG----------LVKIFVKYSDSMQVDRAKAALDGRFFGGNTVKAEAyDQILFDHADYTG 749
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