Conserved Protein Domain Family
SAM_SARM1-like_repeat2
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cd09502: SAM_SARM1-like_repeat2 
SAM domain of SARM1-like, repeat 2
SAM (sterile alpha motif) domain repeat 2 of SARM1-like adaptor proteins is a protein-protein interaction domain. SARM1-like proteins contain two tandem SAM domains. SARM1-like proteins are involved in TLR (Toll-like receptor) signaling. They are responsible for targeted localization of the whole protein to post-synaptic regions of axons. In humans SARM1 expression is detected in kidney and liver.
Links
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Statistics
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PSSM-Id: 188901
Aligned: 13 rows
Threshold Bit Score: 103.528
Created: 11-Mar-2010
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
ABW37993      210 DYSSCDSTKLRRWLRRVGP--EYMQYTYHMVHCGIDRTTLEWLTEDHLLeDCGIVNGVHRMKIQNAIKAGSR 279  Florida lancelet
Q86DA5        680 DYSSVDESNLDNFLMGLSP--ELSVYTYQMLTNGVNRSLLSSLTDEMMQnACGITNPIHRLKLTQAFETAKH 749  nematode
XP_001601657  638 DYSSRDTGNLNNFLQQVGQ--EFSIYTYSMLNAGVDKDSIKNLTEDQLLaECGITNSIHRLRILDAIKNIQY 707  jewel wasp
XP_415814     455 NYSTCDRSNLSDWLGGIDP--MFRQYTYNLLTCGINRNFLHRVTEQQLQeDCHISTGFHRIRILSAARETLH 524  chicken
XP_001688747  757 DYSSRDTDGLHAFLSRIGP--EYTIYTYTMLNAGVDIESLRTLDEDQLTaTCGITNAIHRSRILQVIKLNES 826  Anopheles gambiae str...
XP_002647086  180 DYSKIDVTNLEKRLEAVSP--ALTVYTYQMLSNGIDSKVLPSLTYEIMT-KCGIVNPVHQLKLAKFYGIKER 248  Caenorhabditis briggsae
NP_729327     730 DYSSKDTAKMHQFLSEIGT--DYCTYTYAMLNAGIDKCALPHVNEDMLMtECGIHNSIHRLRILNAVKNLEN 799  fruit fly
XP_002400834  758 DYSSVDTTNVNEILQSLGT--DFSQYTYRMLQSGVDIESLKMLNDEQLShECGIDNSIHRLRIGQAIRGLNQ 827  black-legged tick
ABB97045      765 DYSSCDTISLNMILQELGS--EYSQYTYIMLQAGLSRDVFPFLTEDQLEeVCGISNSIHRRRIWQALLGSTH 834  Southeast Asian horse...
XP_001949100  464 DYSSKDSTGLHSFLKSIDPmfDYSVYTYPMLNAGINMNTIRSLTADQLLnDCKITNTIHHPVILNAIKGMKL 535  pea aphid
NP_001124068  474 NYSTCDPNNLADWLADADP--RFRQYTYGLVQSGVDRNNIVHITDQQLLtDCHVENGIHRAKILSAARRPSK 543  zebrafish
XP_002735153  488 NARWRDHKEISNWLKDLGP--EYNQYTYNLVNCGIDMNMLTLITEEHLTyDAGISNGVHRTRILNAAKPELS 557  Saccoglossus kowalevskii
Q6SZW1        478 NYSTCDRSNLADWLGSLDP--RFRQYTYGLVSCGLDRSLLHRVSEQQLLeDCGIHLGVHRARILTAAREMLH 547  human
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