Conserved Protein Domain Family

smart00192: LDLa 
Low-density lipoprotein receptor domain class A
Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.
PSSM-Id: 197566
View PSSM: smart00192
Aligned: 315 rows
Threshold Bit Score: 29.1386
Threshold Setting Gi: 121956059
Created: 13-Jul-2011
Updated: 2-Oct-2020
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
Q17496        185 RCDLG--EFRCL----DGE--CLDVSK-VLDGQEDCLDSSDE 217  Caenorhabditis elegans
Q26632        147 TCPGDvrRFHCD----NSI--CIERSL-ICDLRCNCDNCDDE 181  Strongylocentrotus purpuratus
Q21496        155 CTAGe---FACKv---SEQ--CISLDR-RCNGLIECDDGTDE 187  Caenorhabditis elegans
Q26632        233 CHIRRe--FYCEv---NYK--CLQRDR-RCDGTVDCPGGDDE 266  Strongylocentrotus purpuratus
Q22179        290 TCIg---KFVCGtsrgGVS--CVDLDM-HCDGKKDCLNGEDE 325  Caenorhabditis elegans
NP_523947    1705 dQIQipnKFVCK----KMS--QIVDIMmRCDRKVDCEDGTDE 1740 fruit fly
XP_001352853 1320 LCPG----FICVw--gGKR--CIAKRQ-RCDRNVDCLGGEDE 1352 Drosophila pseudoobscura pseudoobscura
EDL79056     1312 HCPSTq--WQCP----GYSt-CINLSA-LCDGVFDCPNGTDE 1345 Norway rat
NP_492127    1358 KCPFEh--VACE----NDQetCIPLHQ-LCDGKTHCPGGTDE 1392 nematode
P46023         78 GCLQS--EFQCN----HTT--CIDKIL-RCDRNDDCSNGLDE 110  great pond snail
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