3EDH,4GWM


Conserved Protein Domain Family
Astacin
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pfam01400: Astacin (this model, PSSM-Id:279708 is obsolete and has been replaced by 426242)
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Astacin (Peptidase family M12A)
The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family contain two conserved disulphide bridges, these are joined 1-4 and 2-3. Members of this family have an amino terminal propeptide which is cleaved to give the active protease domain. All other linked domains are found to the carboxyl terminus of this domain. This family includes: Astacin, a digestive enzyme from Crayfish. Meprin, a multiple domain membrane component that is constructed from a homologous alpha and beta chain. Proteins involved in morphogenesis and Tolloid from drosophila.
Links
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Statistics
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PSSM-Id: 279708
Aligned: 22 rows
Threshold Bit Score: 255.673
Created: 14-Jul-2016
Updated: 4-Aug-2016
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3EDH_A   8 RVWPDG-VIPFVIGGNFTGSQRAVFRQAMRHWEKHTCVTFLERTDE----DSYIVFTYRPCGCC-SYVGRRgGGP-QAIS 80  human
Q21388 323 QKWPSTsPIPYTFDSSLDNLDQNDVRGAISEIEQKTCIRFKYFASPpkgnHINYQKVNSPSFCG-LSYIGRvEPA-NPVY 400 Caenorhabditis elegans
Q21432 339 KKWDPSsPIRYVLDSSLEDLDKNDVRAAIYEIEKNTCIRFKELSSPptgsHIVYYKVDSPTFCGlSYVGRA-DPA-NPVY 416 Caenorhabditis elegans
4GWM_A  47 YRWPHT--IPYVLEDSLEMNAKGVILNAFERYRLKTCIDFKPWAg-----ETNYISVFKGSGCW-SSVGNRrVGK-QELS 117 human
Q19269 123 KLWPEG-QVPYMLEEGMTNDQRTAIAQAFDEYKTKTCVRFVPKTDDd--fDYIYVKRNVAFGCS-SYVGRA-GGN-QTVS 196 Caenorhabditis elegans
P55115 121 QLWPEG-RIPYTISSQYSSYSRSLIAASMQEYASHTCIRWVPKE-Aa---DVNYVHIYPDRGCY-SMVGKM-GGK-QSLS 192 Caenorhabditis elegans
Q18439 119 RKWPNG-RIPYVISNQYNDRERAVLARSFQAYHDKTCVRFVPRT-Av---DNDYLYIGKIDGCY-SDVGRA-GGR-QELS 190 Caenorhabditis elegans
P55113  87 KLWPNA-RIPYAISPHYSPHERALLAKAVKQYHEKTCIRFVPRQ-Tg---EPDYLFIGKVDGCF-SEVGRT-SGV-QVLS 158 Caenorhabditis elegans
P55112 102 RRWPNN-EIPYTLSSQYGSYARSVIANAMNEYHTKTCVKFVARDPSk---HHDYLWIHPDEGCY-SLVGKT-GGK-QPVS 174 Caenorhabditis elegans
P98060 138 ASRP----IIYAFDGSHTQREQRIIELALEHWHNITCLNFQRNDQAn---SGNRIVFTDVDGCA-SNVGRHpLGEeQLVS 209 Caenorhabditis elegans

3EDH_A  81 IG-KNCD-KFGIVVHELGHVVGFWHEHTRPDRDRHVSIVRENIQPGQEYNFLKMEPQEVESLGETYDFDSIMHYARNTFS 158 human
Q21388 401 LSfQCGN-GRGIAVHETMHALGVNHQHLRMDRDKHIKVDWSNINPQQYDAFVVADSKLYTTYGVKYAYDSIMHYNAYTGA 479 Caenorhabditis elegans
Q21432 417 LS-FGCDnNKGVAIHETMHALGVAHQHLRNDRDQFITINWSNIDPQQYDAFVVVDSKLYTSYGVKYAYDSIMHYNGYTAA 495 Caenorhabditis elegans
4GWM_A 118 IG-ANCD-RIATVQHEFLHALGFWHEQSRSDRDDYVRIMWDRILSGREHNFNTYSDDISDSLNVPYDYTSVMHYSKTAFQ 195 human
Q19269 197 LEvDKCF-SKGIIAHELMHALGFFHEHSRTDRDDFVDINEDNIRPGMMRNFEKYPRKIIDSLGMPYDYESVMHYHKLAFS 275 Caenorhabditis elegans
P55115 193 LG-SGCI-QKGIILHELMHAVGFFHEQSRTDRDDHITIMWNNIQAGMQGQFEKYGHGTIQSLGTGYDYGSIMHYGTKAFS 270 Caenorhabditis elegans
Q18439 191 LD-NGCL-QYDTAIHELMHSVGFYHEHERWDRDEHITILWHNIDREAYDQFGKVDLAESSYYGQLYDYYSIMHYDSLAFS 268 Caenorhabditis elegans
P55113 159 LD-NGCM-EYATIIHEMMHVVGFYHEHERWDRDNFIDIIWQNIDRGALDQFGKVDLSKTSYYGQPYDYKSILHYDSLAFS 236 Caenorhabditis elegans
P55112 175 LD-SGCI-QVGTIVHELMHAVGFFHEQSRQDRDSYIDVVWQNVMNGADDQFEKYNLNVISHLDEPYDYASIMHYGPYAFS 252 Caenorhabditis elegans
P98060 210 LA-PECI-RLGVIAHEVAHALGFWHEQSRPDRDQYVTVRWENIDKDSKGQFLKEDPDDVDNAGVPYDYGSIMHYRSKAFS 287 Caenorhabditis elegans

3EDH_A 159 RGIFLDTIVPKYEVngVKPPIGQRTRLSKGDIAQARKLYkCPA 201 human
Q21388 480 VNIAKPTMIPLVNQqaNIGLLGQRAKMSNADVEILNKMY-CKS 521 Caenorhabditis elegans
Q21432 496 QNIAIPTMNPKTNSavNLKVLGQRQKMGTTDIELLKKMY-CQP 537 Caenorhabditis elegans
4GWM_A 196 -NGTEPTIVTRISD--FEDVIGQRMDFSDSDLLKLNQLYnCSS 235 human
Q19269 276 RNG-KPTIIPKDN----EADVGQRYKLSEMDSKKVNKLYqCGE 313 Caenorhabditis elegans
P55115 271 RNG-QPTMIPKKN----GATIGQRNGFSKVDKFKINTLYgCPV 308 Caenorhabditis elegans
Q18439 269 KNG-FETMVAKQSE--MTAVIGAAIDFSPIDILKMNLMYqCSD 308 Caenorhabditis elegans
P55113 237 KNG-FPTMLPKVK----SATIGNARDFSDVDISKINRMYnCPV 274 Caenorhabditis elegans
P55112 253 -GSGKKTLVPKKSG---SERMGQRVKFSDIDVRKINKLYnCPG 291 Caenorhabditis elegans
P98060 288 KFDDLYTISTYVTD--YQKTIGQRDQLSFNDIRLMNKIY-CSA 327 Caenorhabditis elegans
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