Conserved Protein Domain Family
L_HMGIC_fpl
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pfam10242: L_HMGIC_fpl (this model, PSSM-Id:287244 is obsolete and has been replaced by 463019)
Lipoma HMGIC fusion partner-like protein
This is a group of proteins expressed from a series of genes referred to as Lipoma HMGIC fusion partner-like. The proteins carry four highly conserved transmembrane domains in this entry. In certain instances, eg in LHFPL5, mutations cause deafness in humans and hypospadias, and LHFPL1 is transcribed in six liver tumor cell lines.
Links
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Statistics
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PSSM-Id: 287244
Aligned: 18 rows
Threshold Bit Score: 176.749
Created: 23-Mar-2017
Updated: 23-May-2017
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q6ZUX7   9 RSMLWTLLSIVVAFAELIAFMSADWLIGka----rSRGgvepagpgggspEPYHPTLGIYARCIrn---pgVQHfqRDTL 81  human
Q2M056  25 IGVLWAIFTICYAIIGIVAFVTPEWIGD-------PD-------------NDGAGRLGLWQQCQ---------RdeIFDN 75  Drosophila pseudoobscura
Q9XVU1  19 VGAIWVLCGLCTTVLQTLALIHPTWIG-----------------------SDEGGYFGLYDYCG---------------T 60  Caenorhabditis elegans
Q8BM86   8 TGVIWALLSFLSAATSCVGFFMPYWLWG-------SQ-------------LGKPVSFGTFRRCSypvhdesRQMmvMVEE 67  house mouse
Q4RUW4   9 RSMLWTLLSIIVAFAELITFMSPDWLMG-------FPRsdsna---gedsREYRPSLGLYSRCLr------IGSqgVGVS 72  spotted green pufferfish
Q568B9   9 RSMLWTLMSIVVAFAELVAFMSAEWLVG-------YSEgselnftvtashRSDQRTLGIYNRCL-------KVAqqKVVQ 74  zebrafish
Q4S279   9 RSMLWTLLSIVAAFGELIAFMSTDWLVGyp----rTPDavfgrhgataagEAYRPTLGIYGRCIk------LPHlqRGIL 78  spotted green pufferfish
Q7PMA1  11 RSLLWFLVTLIACMTLFGAIVLPKWLIGpeviqirNEEgn--------ftVLRHPSVGIYNRCK--------RMgrIEYN 74  Anopheles gambiae str...
Q9W0X9   9 ASLVWFLCSLVADMLFAVALVTPRWLVGpa----qGTDst--------asSHHQSSVGIYTRCK--------VMqeGGFQ 68  fruit fly
Q292M2   9 GSLVWFLCTLVADMLIAAALVTPRWLIG-------PVQpvdel---ssvsSQRQSSVGIYTRCK--------VMhqVGYH 70  Drosophila pseudoobscura

Q6ZUX7  82 CGPYAESFGEIASGF----W-QATAIFLAVGIFI-LCMVALVSVFTMCVqs-imKKSIFNVCGLLQGIAGLFLILGLILY 154 human
Q2M056  76 CRRRWENVLAVPTFS----F-QLATFFMMGAIGLaLLTIFFLVCLLFMK-----STRVFHICGWMQIISALCMIVACAAF 145 Drosophila pseudoobscura
Q9XVU1  61 SECPWSPFRVRPLSM----WfEISAFLVLAATVLsFLAIFSILLLVLLR-----DRHAFILCSWLHFFAFVFMLAGCVLY 131 Caenorhabditis elegans
Q8BM86  68 CGRYA-SFQGIPSTE----W-RICTIVTGLGCGL-LLLVALTALMGCCVse-liSRTVGRVAGGIQFLGGLLIGAGCALY 139 house mouse
Q4RUW4  73 CGPYAGTFGEVASGF----W-QAAILFLAAGTLL-LGGVACISIFSLCFqs-ilKKSLFNICGLLQAIAGLLLMVGLMLY 145 spotted green pufferfish
Q568B9  75 CGPYATDFMEIASGF----W-QATVIFLVIGIFL-LSVVGILSVFSMCFqs-ilKKSIFNVCGLLQGIAGLFLILGLMLY 147 zebrafish
Q4S279  79 CGPYAIHFGEIASGF----W-QATSIFLAAGILL-LCAVAFISVFTMCFqs-imKKSIFNVCGLLQGIAGLFLILGLMLY 151 spotted green pufferfish
Q7PMA1  75 CGNFDLNGLLTDSTVfpvpW-KFTMTLMCVGTML-LGLTLVSTLVTCCRlhsvyGFSMHKLLCIFQGVSAMLVLCGYLVY 152 Anopheles gambiae str...
Q9W0X9  69 CGRFDLDGLATDSSVypneW-KAAMFFVMLGFSL-LSVTVILTLITCCRqs-acGKSIHNMTACAQVVAGICMMLGLFLH 145 fruit fly
Q292M2  71 CGRFDLDGLATDSSVypseW-KAAMFFISLGFAL-LSVTVLLTLLTCCRqs-afGKSIHNMTACAQVVSGISVMLALFLH 147 Drosophila pseudoobscura

Q6ZUX7 155 PAGWGCQKAIDYCGHYASAYKPGDCSLGWAFYTAI----GGTVLTFICAVFSAQ 204 human
Q2M056 146 PFGWNSDDFRKICGPEANRFELGLCGIRWAYPLAIigcvDGVVLATLAFILATR 199 Drosophila pseudoobscura
Q9XVU1 132 PYGWENPRVREIC--ESKKYQLGLCQIRWPYLLAMvlvfDQLCLCCLGFALALK 183 Caenorhabditis elegans
Q8BM86 140 PLGWDSEEVRQTCGYISGQFDLGKCEIGWAYYCTGagaaAAMLLCTWMACFSGK 193 house mouse
Q4RUW4 146 PAGWGSEKVRGYCGPEAAPFRPALCSLGWAFYAAI----GGTLASFLCAVLSAQ 195 spotted green pufferfish
Q568B9 148 PAGWGSKKVVDYCGPDASAYKVGLCSLGWAFYTAI----GGTVLTFICAMFSAQ 197 zebrafish
Q4S279 152 PAGWGSEKVQLYCGQDAAPYRTGLCSMGWAFYTAM----GGTVLTFICAVFSAQ 201 spotted green pufferfish
Q7PMA1 153 PLAWDAPRVRTLCGPDSEPYSPADCTLGVSIYLGAag----vLLTFLSTVLSRK 202 Anopheles gambiae str. PEST
Q9W0X9 146 PMGWRANRIQRLCGMDAEPFYPADCSIGVSFYCGIig----vLLTFTAAGISLK 195 fruit fly
Q292M2 148 PLGWRATRVQRLCGPEAEPFYPADCSIGISFYCGVig----ilLTFAAAGISLK 197 Drosophila pseudoobscura
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