Conserved Protein Domain Family
ECSIT_C
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pfam14784: ECSIT_C (this model, PSSM-Id:317222 is obsolete and has been replaced by 464316)
C-terminal domain of the ECSIT protein
This family represents the C-terminal domain of the evolutionarily conserved signaling intermediate in Toll pathway protein, an adapter protein of the Toll-like and IL-1 receptor signaling pathway, which is involved in the activation of NF-kappa-B via MAP3K1. This domain is missing in isoform 2. Fold recognition suggests that this domain may be distantly homologous to the pleckstrin homology domain
Links
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Statistics
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PSSM-Id: 317222
Aligned: 37 rows
Threshold Bit Score: 138.174
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q9N580       222 SPMQQILISELrKGDEVFVDAA-KVYLQDRVIPFITLTGNTK-LEPLNEFknedmDED-------------YTNWYADWQ 286 Caenorhabditis ...
XP_970998    230 aPIQKDLLKRHdVTEPLYVEGPfRVWLKHQQVTYFTLRKNAKfVAPIKE------DLDdvsd-----ikipFFN------ 292 red flour beetle
EFX69389     244 SANQRDLLAKLkEKQTVYVEGAfTIWLRRTSINYFILRSEPVpLTEEEQKqrneyDYDdvse-----lrswMFG------ 312 common water flea
XP_002404254 256 SPDQRQLVKDQpTDKPLRIEGPfSTYLRNAAISYFVLRAEPVpIRVLEi------DSDdvsn-----ipltMFGEK---- 320 black-legged tick
XP_001948200 234 SPDQKKIVANHpDNIPIYIEGGfRIWLRKQSIIYFILRTEPSpAIKNEEEe----DEDdisn-----frvpFF------D 298 pea aphid
CRZ23399     237 SHLQKKLLQSLrKSTTLYVDGPnKVYLMDNCIEYVGLFSNPK-SHYYEKYd----Dnnl---------dedFENWESEWD 302 Brugia malayi
NP_500631    222 SPMQQILISELrKGDEVFVDAA-KVYLQDRVIPFITLTGNTK-LEPLNEFk----NEDmd---------edYTNWYADWQ 286 Caenorhabditis ...
XP_015781262 298 SPVQKKLINKL--NEPLYIDGPhIMWLKDHMISYFILKTAA----PEELKe----NEEdle-----------dmrDLPLY 356 two-spotted spi...
EHJ72448     171 SRIQKVLLAEQpPDIPLVIKGPfNIYLRDQVVTYFLLLGKTRpEYEDNT------DTDdvskiqkpvgipgVIG------ 238 monarch butterfly
XP_002634178 224 SPSQQLLLSELqKGEEVFVDGG-NVYVQDKLIPFVTLTGTTK-LSPLNEFkkeelDEN-------------YSNWFEEWK 288 Caenorhabditis ...

Q9N580       287 KQRGEAKR-------SIHEQDHETIFAMGAMYKDDNATAIRWIDNLQK-T-NPNMENLRFRVRL 341 Caenorhabditis elegans
XP_970998    293 --IKPPVKnlt-vvpSVHEQEDGTILALCATGTSSKDSLVSWIRHLEK-D-NPVLAEVPVVFTL 351 red flour beetle
EFX69389     313 -EENLTRKdiv-vqpSVHEQEDGTILAIAITGTCSKDSLLSWIRFLEK-T-NPNLANLSILFat 372 common water flea
XP_002404254 321 ----PPPKelv-kpsTVHEQEDGIILALCATGTSSRDSLLSWLRMLQE-D-NAKLKEIPVIFTL 377 black-legged tick
XP_001948200 299 KPIPKKSDkia-kkkTVHEQEDGTIIAVAATGTSSKNSLLSWIRFLEK-DgNPRLTHIPILFTs 360 pea aphid
CRZ23399     303 RRYEKRp--------NIHEQQHETVLALSVFGKVYRKTAIAWISHLQE-T-NPSLHSAQVLFRT 356 Brugia malayi
NP_500631    287 KQRGEAKR-------SIHEQDHETIFAMGAMYKDDNATAIRWIDNLQK-T-NPNMENLRFRVRL 341 Caenorhabditis elegans
XP_015781262 357 AHGGLSKKqhiekmeAIHQSSEGTICGLVATGTSSRDSLLSYIRILKH-H-LPKLKDLNIIFTq 418 two-spotted spider mite
EHJ72448     239 ------KVtlpqvkcTVHEQDDGTIVAVCATGTSSRDSLLSWIRLLEKhD-NPALANVPVIFTL 295 monarch butterfly
XP_002634178 289 KERHEAKR-------SIHQQDHETVFAMGAMFQNDNATALRWMDQLQK-R-NPNLENLRIRVRL 343 Caenorhabditis briggsae
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