5C3V,4TZ7,5E3S


Conserved Protein Domain Family
PIPKc_PIP5KI
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cd17301: PIPKc_PIP5KI 
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Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in type I phosphatidylinositol 4-phosphate (PtdIns(4)P) 5-kinases (PIP5KI) and similar proteins
PIP5KIs, also known as PIPKIs, or PI4P5KIs, phosphorylate the head group of phosphatidylinositol 4-phosphate (PtdIns4P) to generate phosphatidylinositol 4,5-bisphosphate (PtdIns4,5P2), an essential lipid molecule in various cellular processes. Three distinct PIP5KIs have been characterized in erythrocytes, PIP5K1alpha, PIP5K1beta, and PIP5K1gamma isoforms.
Links
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Statistics
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PSSM-Id: 340438
Aligned: 26 rows
Threshold Bit Score: 480.976
Created: 5-May-2016
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1: catalytic core residues [active site], 3 residue positions
Conserved feature residue pattern:K D DClick to see conserved feature residue pattern help
Evidence:
  • Comment:Lys proposed to bind the alpha-phosphate of ATP; mutation of this residue in PIPKI-alpha and PIPKII-alpha destroys enzyme activity.
  • Comment:1st Asp functions as a weak base
  • Comment:2nd Asp binds catalytic Mg2+ or Mn2+
  • Citation:PMID 9753329
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                         
5C3V_A         13 SALKGAIQLGITHSVGSLSqk-peRDVLMQDFEVVESIFFPSqgSSSTPGHhhGDFKFKTYAPIAFRYFREMFgirPDDY 91   zebrafish
XP_001745820  134 QELMSAIQMGIRQSIGYVMqr-rkRDILVQDFDEVESQNYPRegTSTTPAHhfESFKFSTYAPVAYRFFREKFsidTGDF 212  Monosiga brev...
XP_004348939   99 SDLMQGIQLGIRHSVGSITpk-qsRDLLMIDFEEHEIVDFPSegGTYTPAHssNSFRFKSYAPRAFRHFREAFgikAEDF 177  Capsaspora ow...
CBY09966       43 DHISGALQLGITHSVGSHTv---dRDVLLQDFEVIETIVFPKagTTLTPHHtfDDFRFKSYAPLAFRYFRDIFnisTEDF 119  Oikopleura di...
XP_002108154    3 SDISTALQLGIEHSVGKLSsk-heRDVLMQDFQDIDVVFFPRdgSTSTPAHhhADFTFKTYAPIAFRFFRELFgikPQDF 81   Trichoplax ad...
NP_491576      86 NALMQAIQLGISNSIGSLAsl-pnRDVLLQDFEKVDIVAFPAagSTITPSHsfGDFRFRTYAPIAFRYFRNLFhikPADF 164  Caenorhabditi...
CBY32977       63 EAIAGALQLGIAHSVGKLSer-pdRDVLMQDFEVVELIDFPTkgTTLTPPHefGEFTFQSYAPLAMRYFRDIFdisVEGY 141  Oikopleura di...
CDS17288       59 SEIQRAIQLGIQHSIGTLQqk-qvRDVLFRDFEVVETVDFPRsgTKTTPAHglSDFRFRTFAPVAFRSFRDQFqldIRDY 137  Echinococcus ...
XP_019849193   37 STLMASLQLGLQHSIGGLEpk-prRDILMTDFNVIETVDFPSggSAITQAHkyKDFTFTTYSPVAFRFFREAFqikAEDY 115  Amphimedon qu...
XP_009350590  104 YEFMHAIQLGIAASLTHSHnvvddTPTKPEDYEVFETMTFKKtsGDGTPGP--GEFKFQALVPHVFSNFRKIFgftNEQY 181  Pyrus x brets...

Feature 1                                            #                                            
5C3V_A         92 LYSLCn--EPLIELSn-PGASGSLFYVSSdDEFIIKTVQHKEAEFLQTLLPGYFMNLNQNM-RTLLPKFYGLYCVQA--- 164  zebrafish
XP_001745820  213 LMSMCd--SPLRELSn-AGASGSLFWLSHdDLFIVKTVQKGESKFLRKLLPAYYLNITQNQ-RTLLPKFFGHFCYKSa-- 286  Monosiga brev...
XP_004348939  178 MLSLCn--EPLRELSn-PGASGSLFYMSHnDHFIIKTVQRREALFLRQLLPGYYMNLTQNK-KTLLPKFFGLYCYKSa-- 251  Capsaspora ow...
CBY09966      120 LHSIGa--RSLIPIGn-PGASGSCFWITHdDEFIVKTVQQKEASFLTKLLPAYFMAVHQNP-KTLLPKFYGLFNINI--- 192  Oikopleura di...
XP_002108154   82 MISMCd--KRLKEIRn-PGASGSLFFLTNdDRFIIKTVQKKEAQFLQELLPGYYLNFSQNK-KTLLPKFFGLYSYSTs-s 156  Trichoplax ad...
NP_491576     165 LRSICt--EPLKELSn-AGASGSIFYVSQdDQFIIKTVQHKEADFLQKLLPGYYMNLNQNP-RTLLPKFFGLFCYQS--- 237  Caenorhabditi...
CBY32977      142 IHSIIh--EPLTAIGn-PGASGSLFWITHdDEFIIKTVDNKEAEFLMNLLPGYFMNVQQNP-RTLLPKFYGLYCVKK--- 214  Oikopleura di...
CDS17288      138 LHSLCs--QELRELSn-PGASGSIFYISAdDEFIIKTVQHKEANFLQKLLPEYYMNLVQHT-RTLLPKFYGLHCYQS--- 210  Echinococcus ...
XP_019849193  116 LLALCh--QSLRELSn-PGASGSLFYLSAdDEFIIKTVQKKEAVFLQKLLPGYYLNLTQNK-RTLLPKFFGLYQYKC--- 188  Amphimedon qu...
XP_009350590  182 QESIGdhtTPLKILGnpGGVSGSSFYLTHdGQYIIKTMQNREAKLMSHILPKYYANLQDQShAMLLPKLFGQYCYISpgf 261  Pyrus x brets...

Feature 1                                                                                         
5C3V_A        165 DGKNIRIVVMNNLLPraVPMHLKFDLKGSTYKRRASpkerskgvPTYKDLDFMQDm-pEGILLEnDHYTALSRTMQRDCR 243  zebrafish
XP_001745820  287 SGRHIRFIIMQNILPsnLSYAERYDLKGSTKGRFASekeltkknPTLKDIDFIKKh-aNGLIMSdRTYEQLVGTIERDVR 365  Monosiga brev...
XP_004348939  252 LGFNIRFVVMNNLLPsiFRYHERYDLKGSTHARMASqkecmksdPTFKDLDFMNKh-pEGIYLPpSTYEALMRAMQRDCL 330  Capsaspora ow...
CBY09966      193 GGHNIRVCVMNNLLPrrVKMHQKYDLKGSTFKRKASkserekksPTLKDLDFVDFl-pDGIKLEfEYYEALKHTIQADTR 271  Oikopleura di...
XP_002108154  157 GQRNIRIVVMNNLLPsvYQYQVKFDLKGSTHKRKASknerekkcPTLKDLDFKTEl-pEGFGVDpTIYDSLTRTLERDVR 235  Trichoplax ad...
NP_491576     238 LGKNIRLLVMNNLLPqtVTMHEKYDMKGSTYKRMANkaerakphPTLKDLDFLENh-kDGIFIDpTALEALMKSISRDCL 316  Caenorhabditi...
CBY32977      215 ERKHIRVVVMNNLLPrdVEMHYKFDLKGSRYKRKANskeqqkksPTWKDLDFERIfdsKRISLVkESYNAMIETIKRDCL 294  Oikopleura di...
CDS17288      211 SGKNIRFVVMNNLLPssVKMHERYDLKGSSYKRKANerelaktsPTLKDLDFKERh-pNGIWLEaDTYDALMKTIERDCR 289  Echinococcus ...
XP_019849193  189 GGVKIRIVVMNNLLPssLHYHWKFDLKGSTYKRRASpaelekksPTFKDLDFNTQl-pEGLWLPpDKYDILNSTLVRDCQ 267  Amphimedon qu...
XP_009350590  262 SGKYLCFIVMNNLFPanVKIHQKYDLKGSTVFRRAPekelakalPAYRDLDFLDQh-eTGFLLDsELYDELLKSIEADIK 340  Pyrus x brets...

Feature 1                 #                                                                       
5C3V_A        244 VLQSFKIMDYSLLVGIHILhrageeastavpdtqkkgqgqkpl------------------------------------- 286  zebrafish
XP_001745820  366 VLESFRIMDYSLLVGLFVPsrgapsayssssahqftvranasaststvhlctvsgappveglnlngvyesrqgrskdgrf 445  Monosiga brev...
XP_004348939  331 VLRSFKIMDYSLLVGLHKLdetelqrnsmdsqtsmpdvtpppthansfdlmsspdkpqsffssprasasvskeek----- 405  Capsaspora ow...
CBY09966      272 LLHSFKIMDYSLLLGIHNEtveaesrdkeekksidseardrskhis---------------------------------- 317  Oikopleura di...
XP_002108154  236 VLRSFKIMDYSLLIGVHKLtevsrswsvseadsrlrs------------------------------------------- 272  Trichoplax ad...
NP_491576     317 VMESFKIMDYSLLVGIHNVelgikeraeqnreshpapstssdtfs----------------------------------- 361  Caenorhabditi...
CBY32977      295 VLNSFSIMDYSFLIGVHKCsvgeiasmesmslsasnsrgnsvfkrsa--------------------------------- 341  Oikopleura di...
CDS17288      290 VLESFQIMDYSLLLGVHNFdraerdrqnrkserspdngivanavsgaggteqnlrtltlsesskrrsdgdavg------- 362  Echinococcus ...
XP_019849193  268 VLESFGIMDYSLLLGVYNVdeavrageppptpttetvgeqagaadgdmtgggggetdere-------------------- 327  Amphimedon qu...
XP_009350590  341 VLASFKIMDYSLLIGVHKLdasgqhppglqv------------------------------------------------- 371  Pyrus x brets...

Feature 1                                                                                         
5C3V_A            --------------------------------------------------------------------------------      zebrafish
XP_001745820  446 kfvmvqtthnnrsldesddqtdgtsgpssvtklymsfddtnsqwliardpenfvvlanlqtsamfpnsadaawqvkdgdh 525  Monosiga brev...
XP_004348939      --------------------------------------------------------------------------------      Capsaspora ow...
CBY09966          --------------------------------------------------------------------------------      Oikopleura di...
XP_002108154      --------------------------------------------------------------------------------      Trichoplax ad...
NP_491576         --------------------------------------------------------------------------------      Caenorhabditi...
CBY32977          --------------------------------------------------------------------------------      Oikopleura di...
CDS17288          --------------------------------------------------------------------------------      Echinococcus ...
XP_019849193      --------------------------------------------------------------------------------      Amphimedon qu...
XP_009350590      --------------------------------------------------------------------------------      Pyrus x brets...

Feature 1                                                                                    #    
5C3V_A        287 -------------------------------yctaiesiqgesksktspqpyesmGGIPAFNSKGERLLVFIGIIDILQs 335  zebrafish
XP_001745820  526 fravpamesrcrerevavnpiassnaaassrmrrrnsivfqtvdtsdgeddeqlmNGIPAYNSDGQKVYLYVGIIDILQn 605  Monosiga brev...
XP_004348939  406 neslrravlykklseiaavtgtplnvlnkkfqkqvsyvadisetldldpeletyaGGMLAYTDKKERCIIFLGIIDILQq 485  Capsaspora ow...
CBY09966      318 -----------------------------lnpttlqnilaksarperfqiaadpwGGIPATNSSGDKLKIYLGIIDILQc 368  Oikopleura di...
XP_002108154  273 --------------------------------------asggassidavtatarlGRIHAYTTSGEAVMLFIGIIDILQs 314  Trichoplax ad...
NP_491576     362 -----------------------------gekaenhkvlqekfsvwdtgdgdvphGGVPARNSNGDRLVLYLGIIDILQn 412  Caenorhabditi...
CBY32977      342 ---------------------------lysspmeqvftgsqvnlqlsqhkvdqnwGGIPALLPDGTQVLIYCGIIDILQc 394  Oikopleura di...
CDS17288      363 --rvrrstspfarnafrarsgnkrlaaystamesieaktepveieptdsekatllGGLPARSYSGDRLFLFIGIIDILQs 440  Echinococcus ...
XP_019849193  328 ---------------rsrtflqsriearknfsifnpetlasdtdlqdfptpgypeGYIQARTKGGDRLLLYLGVIDILQs 392  Amphimedon qu...
XP_009350590  372 -------------------------------------------atvkslqetrswAGIPATDSEGKKVLLFIGIIDILQt 408  Pyrus x brets...

Feature 1                                                      
5C3V_A        336 YRLVKKLEHSWKALLHDGDtvSVHRPSFYADRFQKFMCSTVFRKS 380  zebrafish
XP_001745820  606 YGTRKALEHTYKSMIYDGDtvSVHRPDFYRERFLRFMTDQVFRPS 650  Monosiga brevicollis MX1
XP_004348939  486 YQLKKRLEHSFKALLYDGEavSVTNPSFYAARFQDFFAKRVFKVM 530  Capsaspora owczarzaki ATCC 30864
CBY09966      369 YKTMKKIEHAWKAIIYDGRtvSVHRPGFYKKRFEGFLFGTVFRNL 413  Oikopleura dioica
XP_002108154  315 YRFIKKLEHTYKSILHDGDavSVTSPGFYSERFVNFCKSSVFTKR 359  Trichoplax adhaerens
NP_491576     413 YRLLKKMEHTWKAILHDGDtiSVHNPNFYASRFLTFMTEKVFKKG 457  Caenorhabditis elegans
CBY32977      395 YKLLKRTEHFFKSLYTNGEeiSVVRPGFYAERFQDFLKNKVFIPQ 439  Oikopleura dioica
CDS17288      441 YRMVKKMEHTIKSVVIDAEtvSVTNPSFYAKRFQNALGNCIFRRT 485  Echinococcus granulosus
XP_019849193  393 YRLKKRLEHGFKSIITDGDtvSVHNPSFYAQRFLTFLNDVVFKKD 437  Amphimedon queenslandica
XP_009350590  409 FRVAKKLEFAFKSVVYDRNevSVTEPNFYAQRFRNFIATKVFKRV 453  Pyrus x bretschneideri

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