Conserved Protein Domain Family
Shugoshin_C
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pfam07557: Shugoshin_C (this model, PSSM-Id:400099 is obsolete and has been replaced by 462207)
Shugoshin C-terminus
Shugoshin-like proteins contain this conserved sequence at the C-terminus, which is rich in basic amino-acids. Shugoshin (Sgo1) protects Rec8 at centromeres during anaphase I (during meiosis) so that sister chromatids remain tethered. Sgo2 is a paralogue of Sgo1 and is involved in correctly orienting sister-centromeres.
Links
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Statistics
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PSSM-Id: 400099
Aligned: 69 rows
Threshold Bit Score: 30.533
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
EDS44024      95 RPARSArvKAIKNLKEPTLNSKMRQP 120  southern house mosquito
NP_001116771 798 RPRRRA---TPVTYKEPKINCKMRRG 820  zebrafish
XP_003220112 931 RPKRQR--KNEVSYAEPKINSKLRRG 954  green anole
XP_017207769 554 RRQRRA--ASAVNYKEPSINTKLRRG 577  zebrafish
XP_001089281 474 PKRRCT---VSVNYKEPTLASKLRRG 496  Rhesus monkey
Q9CXH7       464 TKRRCS---TIKSYKEPTLASKLRRG 486  house mouse
XP_012024690 471 RKRRCT--AAVVSYKEPTLASKLRRG 494  mouflon
NP_001186577 544 RKRRSC--TLSVSYKEPSIAGKLRRG 567  chicken
XP_005040983 549 RTRRSC--TITVNYKEPSIVGKLRRG 572  Collared flycatcher
CAF99404     198 RKRRCT---MAVDYTEPSLNAKLRRG 220  spotted green pufferfish
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