Conserved Protein Domain Family
mRING-HC-C3HC3D_PHRF1

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cd16635: mRING-HC-C3HC3D_PHRF1 
Modified RING finger, HC subclass (C3HC3D-type), found in PHD and RING finger domain-containing protein 1(PHRF1) and similar proteins
PHRF1, also known as KIAA1542, or CTD-binding SR-like protein rA9, is a ubiquitin ligase which induces the ubiquitination of TGIF (TG-interacting factor) at lysine 130. It acts as a tumor suppressor that promotes the transforming growth factor (TGF)-beta cytostatic program through selective release of TGIF-driven promyelocytic leukemia protein (PML) inactivation. PHRF1 contains a plant homeodomain (PHD) finger and a modified C3HC3D-type RING-HC finger.
Statistics
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PSSM-Id: 319549
View PSSM: cd16635
Aligned: 15 rows
Threshold Bit Score: 94.0399
Threshold Setting Gi: 190588707
Created: 25-Jul-2013
Updated: 18-Aug-2016
Structure
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Aligned Rows:
 
Zn binding sitemodified
Feature 1:Zn binding site [ion binding site]
Evidence:
  • Comment:Based on the structural evidence that Homo sapiens LNX2 (5DIN) binds two Zn2+ ions through its modified RING-HC finger.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1           #  #              # #  #  #          #  # 
Q9P1Y6        106 ESCPICLNAFrDQAVGTPENCAHYFCLDCIVEWSKNaNSCPVDR 149  human
EKC34304      102 ETCPICLDRLrDQDVGTPESCDHVFCLDCIQEWAKNvNTCPVDR 145  Pacific oyster
AAI42797      101 EKCPICLNSFhEQPVATPETCEHYFCLDCILEWSKNaNSCPVDR 144  zebrafish
EEC04005       65 ERCPICLNRFlGQEEGTPESCDHVFCLDCIQEWARNvNTCPVDR 108  black-legged tick
XP_006814886  170 EKCPVCLNSFdEQDVGTPESCDHTFCLECILEWSKNvNTCPVDR 213  Saccoglossus kowalevskii
XP_013414317  154 ERCPVCLNRLlDQDVGTPEACDHNFCLECINEWAKNvNTCPVDR 197  Lingula anatina
XP_011683128  177 EKCAICLRSFnDQEVGSPESCDHTFCFECIYEWSKNvTTCPVDR 220  purple sea urchin
XP_002124973   64 ASCAICLNEFtKQKVGVPNNCRHIFCVDCILEWSKNaNSCPVDR 107  Ciona intestinalis
EEN64508      124 ESCPICLNEFeLQEVGTPVNCQHNFCIDCILEWSKNtNSCPVDR 167  Florida lancelet
EFX67875       57 ATCPICLLKFkGQAIGFPEVCGHPFCLDCILEWSKTvQTCPNDR 100  common water flea

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