Conserved Protein Domain Family
AKAP_110

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cl14906: AKAP_110 Superfamily 
A-kinase anchor protein 110 kDa (AKAP 110)
This family consists of several mammalian protein kinase A anchoring protein 3 (PRKA3) or A-kinase anchor protein 110 kDa (AKAP 110) sequences. Agents that increase intracellular cAMP are potent stimulators of sperm motility. Anchoring inhibitor peptides, designed to disrupt the interaction of the cAMP-dependent protein kinase A (PKA) with A kinase-anchoring proteins (AKAPs), are potent inhibitors of sperm motility. PKA anchoring is a key biochemical mechanism controlling motility. AKAP110 shares compartments with both RI and RII isoforms of PKA and may function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction.
Links
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Taxonomy: Theria
PubMed: 1 link
Protein: Related Protein
Related Structure
Statistics
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Accession: cl14906
PSSM Id: 449376
Name: AKAP_110
Created: 5-May-2011
Updated: 8-Mar-2022
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