Conserved Protein Domain Family
WBS28

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pfam15164: WBS28 
Williams-Beuren syndrome chromosomal region 28 protein homolog
WBS28 is an integral membrane family. These proteins have been identified as being linked to Williams-Beuren syndrome, OMIM:194050. This family of proteins is found in eukaryotes, and are typically 266 amino acids in length.
Statistics
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PSSM-Id: 464540
Aligned: 10 rows
Threshold Bit Score: 327.55
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_001493786   1 MEVVPPVRSSLWGILRLLAKLCVLLVQNRAHLYNFLLLKIVLFNHWLSGLAQEAQGScgqqaYPPTPVfTACPMARVLRA 80 
XP_003124471   1 MEAAPGVRSSLWGTLLVVLKLSVLLVQNRVHLYNFLLLKTTLFNRWLSGLSQEAQGS-----HPPANI-TACPVGRALRA 74 
XP_027382368   1 MEAIPLVRSSLSGTLLVVVKLSALLIQNRAHLYNFLLLKIFLFNHWLLGLTQEAQGF-----HPPSKI-AGCPVGRVLRA 74 
XP_005328589   1 MEAVPPVRSSLLGILMQVVRLSVLLVQNRVHLYSFLLLKISLFRHWVSGLAQEAQGScspqaHPPTGI-ASCPLVRALRA 79 
XP_001077705   1 MEAAPRVRFGLPRILLQVGKLSALLIQNRIHLYQFLLLKMAIFQHWVSGLAQEARGSgsdqaCLLPEViITYALGLVLRA 80 
Q6UE05         1 MEALPPVRSSLLGILLQVTRLSVLLVQNRDHLYNFLLLKINLFNHWVSGLAQEARGScnwqaHLPLGA-AACPLGQALWA 79  human
XP_003794298   1 MEATPPVRSSLWGILLQVMRLSVLLVQNRVHLYNFLLLKIVLFNHWVLGLAQEAQGSisrqaHLAPGN-TACPLGRAIRA 79 
XP_002920135   1 MEPVPPVRSNLLGILLLVVKLSVLLVQNRVHLYNLFLLKILLFNRWLSGLAQEAWGSrgrqaPP-----AASPLGWALWA 75 
XP_849671      1 MEAVPPVRSSLLEILLLVVKLSVLLVQNRVHLYNFLLLKILLFNHWLSGLAQEAWGScsgqvHPPAGL-AASPLGRLLRA 79 
XP_003416695   1 MEAVPPARPRLLGILLQVVRLSVLLIQNRAHLYNLLLLKIILFNHWVSGLAQEA--------HPPPGA-AVCPVGRALRA 71  African savanna...
XP_001493786  81 GLALMEVPVQLVLRAPRLVWAGMLGCARAFSLALKRLGAWEWLGLSVATWMDLLLSCLHSLMLVVLLLLLLTWKLCWKAH 160
XP_003124471  75 GLALIEVPGGLVLRAPKLAWAGMLGWARALGMAPKRLGAWEQLGLSAATWTDVLLSCVHSLMLAALLLLLLIWRLCHKAQ 154
XP_027382368  75 GLTLLEVPVCLALRVPRLVWAGLLGCARALGLGPKWLGAWEQLGLSAATWTDLFLSCLHSLMLAALLLLLLVWRLYQKAQ 154
XP_005328589  80 GLALLWVPMWLLLWGPRLVCEAVLDSARTLGLTLQRLGAGTWLGLSVDTWGQLFLSCLHSLMLAALLLLLLTWRLFQKAH 159
XP_001077705  81 GLALLWVPMWLLLWGPRLSYRVGLCCTHTMKLALGHLCAWEPPGLSPATFRDLFLSCLHRLMLVALLVLLLTWKLLQKAH 160
Q6UE05        80 GLALIQVPVWLVLQGPRLMWAGMWGSTKGLGLAL--LSAWEQLGLSVAIWTDLFLSCLHGLMLVALLLVVVTWRVCQKSH 157 human
XP_003794298  80 GLVLVQVPVWLVLRGSRLVWAGVLGCAWAWGLAL--LGAWEQLGLSVAIWTDLLLSCLHGLMLVALLLLLLTWRLCQKVQ 157
XP_002920135  76 GLGLLRVPVWLGLQAPQLAWAGMRHCARALGLAPK------WLGLSVATCTDLLLSGLHGLMLAGLLLSLLTWRLCRRAH 149
XP_849671     80 GLVLMEVPMWLGLRGPRLMGAAVLRCARALGLAPK------WLGLSAATCMDLLLSCLHGLMLAVLLLSVLTWRLCRNAH 153
XP_003416695  72 GLALIEIPVWLVLWVPRLVWGSVLGCARASGLSPWCLDAWEQLGLSVATWMDLLMSCLHSLMLVALLVLLLVWRLCRVAH 151 African savanna...
XP_001493786 161 R-CSLGWLSSKALLENCVVLELLALLKRLYWWVESTTVLTSWHLAYLVTWTTCLASHLLQAAFEHTAQLAQAQEAEPQEA 239
XP_003124471 155 C-CGLGRLLRKALLENRVVLGLLAPLKRLYWWVESLTALTSWHLAYLVTWTTCLASHLLQAAFEHTVQLAQAQEAEPQKA 233
XP_027382368 155 C-CSLGRLPRKALLQNRVVRRSLALLKSLYWWVESTAALTSWHLAYLITWTTCLASHLLQAAFEHTAQLAQAQEAEPQKA 233
XP_005328589 160 R-FSLGWLPSQ----NCAVLEL----RRLYRWVESTVALTSWHLAYLVTWTTCLASYLLQAAFEHTAQLAEAQGAEPQEA 230
XP_001077705 161 H-SSLGWLHSQ----SSMLLEALALLRRLYLWVEHRTTLTSWNLAYLVTWTTCLASHLLQAAFEHTAQLAQAQEVSFEET 235
Q6UE05       158 C-FRLGRQLSKALQVNCVVRKLLVQLRRLYWWVETMTALTSWHLAYLITWTTCLASHLLQAAFEHTTQLAEAQEVEPQEV 236 human
XP_003794298 158 R-----WLPSKALQENQAVQELLMLLRRLYWWVESTMALTSWHLAYLVTWITCLASHLLQAAFEHTSQMAQDQEAELQEP 232
XP_002920135 150 RlCSLGGLLSKALLDSRVVPELWALQRRLYWWVETTTALT-WHLAYLITWTTCLASHLLQAAFEHTAQLAQSQDAEPPRG 228
XP_849671    154 R-CGLGWLLSKALLGNHVVPELLTLLKRLYWWVENTTAFTSWHLAYLITWTTCLVSHLLQAAFEHTAQLAQAQEPEPSKG 232
XP_003416695 152 R-FSLGQLRSKalleNHMVLELLAPLKLLYWWVESTAGLASWYLAYFVTWTTCLASHLLQGAFEHTAQLA--QEAEPQEA 228 African savanna...
XP_001493786 240 -LGPLSESLFPEPLAPQAGPVLPEHGTPGE 268
XP_003124471 234 sSGLLLESPLPEPLAPEAGPVLPEPGTPGE 263
XP_027382368 234 -LGLSSETPPPGPPAPGARPVLPEPGTPGE 262
XP_005328589 231 -PGPLPESKLHEPSTRKAGPVLPEPGAPGE 259
XP_001077705 236 -SEPSSQFLIPESSTTESGPLPSQPETPGE 264
Q6UE05       237 -SGSSLLPSLSASSDSESGTVLPEQETPRE 265 human
XP_003794298 233 -LGPSLEHLLPEFLAPVAGPVLPEQETPGE 261
XP_002920135 229 -SGTLSASPLPEPLGPEAGPALPEHGTPAE 257
XP_849671    233 -SGPLSESPLPEPLGPEARPALPEHGIPGE 261
XP_003416695 229 -SWILPESPLPDSLTPEAGSALPEPESPGE 257 African savanna elephant
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