Conserved Protein Domain Family
TMEM132D_C

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pfam15706: TMEM132D_C 
Mature oligodendrocyte transmembrane protein, TMEM132D, C-term
TMEM132D_C is the C-terminal family of chordate proteins implicated in panic disorder. TMEM132D is a single-pass transmembrane protein that is highly expressed in the cortical regions of the human and mouse brain. The function is still unknown. It may act as a cell-surface marker for oligodendrocyte differentiation. Additionally, as it may be most strongly expressed in neurons and it colocalizes with actin filaments TMEM132D may be implicated in neuronal sprouting and connectivity in brain regions important for anxiety-related behaviour.
Statistics
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PSSM-Id: 318007
View PSSM: pfam15706
Aligned: 40 rows
Threshold Bit Score: 75.0505
Threshold Setting Gi: 242022904
Created: 29-Jul-2016
Updated: 4-Aug-2016
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_009028175  523 SKFHQTNSNNNNNG--Y--SQHPP-SLHASALTPLEIGMYTLLAVFCLAVFIFIINCAFFMAKHRRkndsnsprknla-s 596  Helobdella ro...
XP_011672815  868 DKAEASTEAPL-DG--G--NDGGL-SDDSDPLSGIEIGMYVLLSVFSLAILAFMVNCVMFMARYRR-------------- 927  purple sea ur...
XP_009293643  882 lekpnfpfppeepkrepplVESNL-IQMFSVFTDIEVCIYALVGLSCLAMIAVLLHCATSSARTRN-------------- 946  zebrafish
XP_017064129  875 yeptvqarqhrgsiqavhkghhgkgiggtgtmttmELGMYVLLTAFCFAIIVFVISCVVYASKFRPamiesgldplsa-g 953  Drosophila eu...
XP_002431877  881 NNHEPTVQARQHHS--AliPHSNFhVRNSNRMTPLEIGMYVLLAAFCFAIVVFVVSCVVYASKFKA-------------- 944  human body louse
XP_013817771   13 EAGKEEAEAREEEEe---eGEEEM-VPAPQRVTDLELGMYALLGIFCLAILIFLVNGVVFVLRYQR-------------- 74   goat
ELK33458       21 AGQEEEAEAREEEG-----GEEEM-VPAPRRVTNLELGMYALLGIFCLAI-IFLVNRWCLCCTTSA-------------- 79   Myotis davidii
XP_001992057  936 HRASIQAVHKTHYGnrA--SGFG-----SGNMSSMELGMYVLLTAFCFAIIVFVISCVVYASKFRPvmiesgldp----- 1003 Drosophila gr...
XP_002028124  882 GSSSIQASHKNHFNgkG--G--------TGTMSSMELGMYVLLTAFCFAIIVFVISCVVYASKFRPaliesgld------ 945  Drosophila pe...
XP_002075390  921 HRSNIQAVHKSHFGg---kGHGN------GNMSSMELGMYVLLTAFCFAIIVFVISCVVYASKFRPaliesgldplsavg 991  Drosophila wi...
XP_009028175  597 nrklssgipkrK-------------DGTVAAt----------TAAVga------aaNCSPDWVWIGRE 635  Helobdella robusta
XP_011672815  928 -----------A-------------KRMPKT-----------HQPV----------PYPQNWVMFGMQ 950  purple sea urchin
XP_009293643  947 -----------R-------------KTPIQC-----------QGQH----------EHRHHWVRLSTA 969  zebrafish
XP_017064129  954 kgngsgasggfR-------------DVRLKE-------------ST----------TNAHDWVWLGRS 985  Drosophila eugracilis
XP_002431877  945 -----------QvgetvdvsssddnNGANIGvsngnsgykglPQST----------TNVHDWVWLGRA 991  human body louse
XP_013817771   75 -----------K-------------EPPDGAi----------DPAS----------PQPHNWVWLGTD 98   goat
ELK33458       80 -----------R-------------SPPNGAl----------DPDS----------PQPYNCMWLGTD 103  Myotis davidii
XP_001992057 1004 ---ltgagkgnA-------------NGGVGGfrdvr---------------lkestTNAHDWVWLGRS 1040 Drosophila grimshawi
XP_002028124  946 ---plsmgkgsG-------------GGGGGGi----------SGGGfrdvrlkestTNAHDWVWLGRS 987  Drosophila persimilis
XP_002075390  992 kgngngsiggfR-------------DVRLKE-------------ST----------TNAHDWVWLGRS 1023 Drosophila willistoni
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