Conserved Protein Domain Family
TMEM132D_C
?
pfam15706: TMEM132D_C 
Mature oligodendrocyte transmembrane protein, TMEM132D, C-term
TMEM132D_C is the C-terminal family of chordate proteins implicated in panic disorder. TMEM132D is a single-pass transmembrane protein that is highly expressed in the cortical regions of the human and mouse brain. The function is still unknown. It may act as a cell-surface marker for oligodendrocyte differentiation. Additionally, as it may be most strongly expressed in neurons and it colocalizes with actin filaments TMEM132D may be implicated in neuronal sprouting and connectivity in brain regions important for anxiety-related behaviour.
Links
?
Statistics
?
PSSM-Id: 464814
Aligned: 36 rows
Threshold Bit Score: 72.7117
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
XP_009028175  523 SKFHQTNSNNNNNGy--SQHP-PSLHASALTPLEIGMYTLLAVFCLAVFIFIINCAFFMAKHRRkndsnsprknla---s 596 
2_pfamImport    1 -----TTTRPTRRNpseSGDD-LVATFRAMSDVEIGTYAVVGVTCVAILAVLLKCASNKLCFRG---------------- 58  
6_pfamImport    1 HNHEPTVQARQHHGs-nNGGGvIASRQHILTPLEIGMYVLLAAFCFAIVVFVVSCVVYASKFKA---------------- 63  
EEB19139      881 NNHEPTVQARQHHSaliPHSNfHVRNSNRMTPLEIGMYVLLAAFCFAIVVFVVSCVVYASKFKAqvgetvd--------- 951 
XP_002075390  921 HRSNIQAVHKSHFGg-kGHGN------GNMSSMELGMYVLLTAFCFAIIVFVISCVVYASKFRPaliesgldplsav--g 991 
XP_001963408  887 HRGSIQAVHKNHHGv-kGAAG-----TGTMSSMELGMYVLLTAFCFAIIVFVISCVVYASKFRPamiesgldplsvgkgn 960 
XP_002028124  882 GSSSIQASHKNHFNgkgG--------TGTMSSMELGMYVLLTAFCFAIIVFVISCVVYASKFRPaliesgld-------- 945 
EDV91764      936 HRASIQAVHKTHYGnraSGFG-----SGNMSSMELGMYVLLTAFCFAIIVFVISCVVYASKFRPvmiesgldp------- 1003
XP_010837933  521 EARKEEAEAREEEEe-eGEEE-MVPAPQRVTDLELGMYALLGIFCLAILIFLVNGVVFVLRYQR---------------- 582 
CAF90877      507 PRGEAQTDAPGARPprvLEGD-LSRAFGALWELEVGVYALAGVCCLALVALLLRCSSRSLCAPA---------------- 569  spotted green...

XP_009028175  597 nrklssgipkrKDGTVAAtTAAVga------aaNCSPDWVWIGRE 635 
2_pfamImport   59 -----------KKTPIQAgPSPAgd------pkDHKHDWVWLESN 86  
6_pfamImport   64 -----------DNGPVVG---GIaqeihppqqtQNAHDWVWLGRS 94  
EEB19139      952 -----vsssddNNGANIGvSNGNsgykglpqstTNVHDWVWLGRA 991 
XP_002075390  992 kgngngsiggfRDVRLKE---ST----------TNAHDWVWLGRS 1023
XP_001963408  961 gsggsggsggfRDVRLKE---ST----------TNAHDWVWLGRS 992 
XP_002028124  946 ---plsmgkgsGGGGGGGiSGGGfrdvrlkestTNAHDWVWLGRS 987 
EDV91764     1004 ---ltgagkgnANGGVGGfrdvr-----lkestTNAHDWVWLGRS 1040
XP_010837933  583 -----------KEPPDGAtDPAS----------PQPHNWVWLGTD 606 
CAF90877      570 -----------QKSPVQ--PGLAag------pePHKHDWrrgarw 595  spotted green pufferfish
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap