2V7S


Conserved Protein Domain Family
LppA

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pfam16708: LppA 
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Lipoprotein confined to pathogenic Mycobacterium
This is a family of lipoproteins found only in pathogenic mycobacteria. These pathogenic lipoproteins may play a role in host-pathogen interactions. Lipoproteins localized to the cell-envelope of pathogenic bacteria are major determinants of virulence. The proteins are localized to the cell-surface via an N-terminal lipidation carried out by a transferase - pro-lipoprotein diacylglyceryl transferase Lgt - which attaches a diacylglyceride molecule to a sulfur atom from a crucial cysteine, and a consecutively acting lipoprotein signal peptidase LspA that cleaves the signal peptide just before the modified cysteine. When the peptidase is inactivated the pathogen has difficulty in replicating inside macrophages.
Statistics
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PSSM-Id: 406985
Aligned: 15 rows
Threshold Bit Score: 146.758
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2V7S_A                35 PDTSRRLT-GEQKIQLIDSXRNKGSYEAARERLTATARIIAdRVSAAIPGQT-WKFDD---DPNiqqsdRNGALc-DKLT 108 Mycobac...
EHR53777              35 GGDINDDPnAGTVQEQFDTLLQRPSFEEMTERYQEMVTKVR-RATVQLGGIPeWRDSKgstPIS-----GAGCGfdFPDI 108
CAM00347               7 AGRPGTTP-GGDVEDQRATLQQRPSIEEASARYDEMQRAVReRLSAEIGSLN-WTPRE---PMS-----SAGCA---DFP 73 
jgi:Sked_25780        47 DRSMAGLPsDDEVVDARRVLMGLPSFEEEQGTSAMVLGDIRtALEVELGPVD-WIHDEvrrGAA-------GCT--PPES 116
WP_012393708          30 GGEQEGPLsPEKVAELENPLRAKPSLEAAKDQYRAAVTRMAdAIAALVPGLT-WSMDV---DSW------NHCG--GEYV 97  Mycobac...
P71655                28 AGE-EGPLsPEKVAELENPLRAKPPLEDAKDQYRAAVTQLAnAITALVPGLT-WRTDM---DTW------TGCG--GEYE 94  Mycobac...
jgi:Gbro_0404         27 FGETEDVS-PQRLTELNDELRGLPTLDVTLEDYRRLRERLTlRIREVAPETY-WRSSAiegDRYpd--hRQSCS--GEWA 100
jgi:Srot_0054         48 DDAPRHMA-QEKVPAFEERYRDKGSVQQAAEDLEAVIARAAdKIAALVPGLT-WKWQY---DPG-----NIGCPa-DAAS 116
goetting:NONO_c57430   2 FENPYQNTdPERTAEAAEQLTKLPTLEETEIHVEAAVNELAdYVSTLVSGLT-WEWAN---NRE-----NESCD--RPYD 70 
MSJTU:JDM601_0148      1 MNQPYGPTpPTEAAQALEELRSLPSFEDTRVQVQAAMKEITvAAGELISGVV-WENPH---EGS-----GEGCQr-RPYE 70 
2V7S_A               109 ADIARRPIAN-SVXFGATFSAEDFKIAANIVREEAAKYGATTESSLFNESAKRDYDVQGN-GYEFRLLQIKFATLNITGD 186 Mycobac...
EHR53777             109 GSDGGTRQIN-GGVSEGAIPDDRWPEVIERVGKIAESYGFNRREVFKDEPGDHDVRFYDSyGGDFVFGTKINTSMVISSG 187
CAM00347              74 NLGGETRVLE-SWRSAGNLPDADWPRAVEIVAEVTAQYGFGAVEVVVDRAGDHEITATDQyGASYLFGTAKNTLLTVSTG 152
jgi:Sked_25780       117 EIPGALSEGA-RSRGALPGGGDQGERALEIVEEVAAQHGFAETSRFVDGTGVQYADMTSDrGGNVSAVAGDRFGIRVTSS 195
WP_012393708          98 WTNAKMAYF--MVGFSGPIPDDKWPQAVRIVKDGGQQFGATTFGVMKDKPGDHDVYLAGHgGVEFKLGTQVASSLTAQSD 175 Mycobac...
P71655                95 WTRAKAAYF--MIVFSGPIPDDKWLQAVQIVKDGVEQFGATGFGVMKNKPADHDVYFAGHgGVEFKCSTQKAAVLTAQSD 172 Mycobac...
jgi:Gbro_0404        101 DTDGRQVQLD-RRVSAVPIGEAHWSEALAVVRETVAEYGLKQIGAYRDLPDDRDIRFSGPgGSALMFGTFKAAVLSIQTP 179
jgi:Srot_0054        117 DTRVTRFATR-LAGFDGAIPEDVWPRAVAIVRSEAEFLGMTAQFKYQDAAKQHDLVFSSQdGGEIRIATAVEAFIRGKTP 195
goetting:NONO_c57430  71 QTQGSKVKLK-NRISHPAIPDAVWPQVLDRARQLAEGIGATGVEVFADEPGNHVVRFYSLeGTE-LFVGSRGAVIGSNTG 148
MSJTU:JDM601_0148     71 QANARGYLLPdEVAVRVAVSERDWVGIQEAARIAAAKLDATELQVMQDQPGNHDVGFYGPaGLYIKVGYRGNLVVSGYTG 150
2V7S_A               187 CFLLQ 191 Mycobacterium tuberculosis H37Rv
EHR53777             188 CFLKN 192
CAM00347             153 CHLPQ 157
jgi:Sked_25780       196 CFLTA 200
WP_012393708         176 CRISE 180 Mycobacterium
P71655               173 CRISR 177 Mycobacterium tuberculosis
jgi:Gbro_0404        180 CRLPA 184
jgi:Srot_0054        196 CRLME 200
goetting:NONO_c57430 149 CRLPA 153
MSJTU:JDM601_0148    151 CRLPR 155
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