GEO DataSets for BioProject (Select 143515) - GEO DataSets

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Items: 2

Select item 2000304421.

Whole-exome sequencing identifies mutations of BCOR in acute myeloid leukemia with normal karyotype

(Submitter supplied) Among acute myeloid leukemias (AML) with normal karyotype (CN-AML), NPM1 and CEBPA mutations define WHO provisional entities accounting for ~60% of cases, but the remaining ~40% remains poorly characterized. By whole exome-sequencing (WES) of one CN-AML patient lacking mutations in NPM1, CEBPA, FLT3, MLL-PTD and IDH1, we newly identified a clonal somatic mutation in BCOR (BCL6 co-repressor), a gene located in chromosome X. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS4280
Platform:: GPL570
24 Samples

Download data: CEL

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Accession:: GSE30442

ID:: 200030442

Select item 42802.

BCL6 corepressor somatic mutation in acute myeloid leukemia with normal karyotype: Ficoll-enriched mononuclear cells

Analysis of mononuclear cells from normal karyotype, acute myeloid leukemia (CN-AML) patients with BCL6 corepressor (BCOR) mutation. CN-AML BCOR mutations are associated with oculo-facio-cardiodental genetic syndrome and poor outcome. Results provide insight into role of BCOR in CN-AML pathogenesis.