GEO DataSets for BioProject (Select 189547) - GEO DataSets

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Items: 2

Select item 2000443551.

Expression data from Adriamycin-treated Emu-myc; Suv39h1-/- B-cell lymphoma

(Submitter supplied) Oncogene-induced senescence (OIS), a terminal cell cycle block countering (pre)neoplastic lesions, is characterised on the molecular level by trimethylated histone H3 lysine 9 (h3K9me3), a transcriptionally repressive chromatin mark linked to silencing of S-phase-promoting genes. Whether H3K9-governed chromatin remodelling influences anticancer treatment-induced senescence (TIS) and whether functional control of this mark impacts on treatment outcome is not known. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS4983
Platform:: GPL1261
10 Samples

Download data: CEL

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Accession:: GSE44355

ID:: 200044355

Select item 49832.

Adriamycin in vitro effect on Eµ-myc transgenic lymphoma cells deficient in Suv39h1

Analysis of lymphoma cells isolated from Eµ-myc mice deficient in H3K9 histone methyltransferase Suv39h1 and treated in vitro with anticancer drug ADR. ADR induces therapy-induced senescence (TIS) in Suv39h1-proficient lymphomas. Results provide insight into the impact of Suv39h1 on TIS induction.