Table 3Summary of frequently used immunocompromised mice

Mouse StrainFull nameImmune Characteristics
Nude miceAthymic nude miceNo thymus, No T cells
SCIDSevere Combined Immunodeficient MiceNo T cells, no B cells
SCID/BeigeSevere Combined Immunodeficient Mice/BeigeNo T cells, no B cells, severe reduced NK cells
NODNon-obese diabetic micePancreatic no T cells, impaired NK cells, macrophages and dendritic cells
NOD/SCIDNon-obese diabetic Severe combined immunodeficiencyNo T cells, no B cells, impaired NK cells, macrophages and dendritic cells
NOG/NSGNOD/SCID/interleukin-2 receptor gamma chain(IL2Rγ)nullNo T cells, no B cells, no NK cells, impaired macrophages and dendritic cells
NOJNOD/SCID/Jak3(Janus kinase 3)nullNo T cells, no B cells, no NK cells, impaired macrophages and dendritic cells
BRGBALB/c Rag-2null/IL2RγnullNo T cells, no B cells, no NK cells
BRJRag-2null/Jak3nullNo T cells, no B cells, no NK cells
Nude R/JBALB/c Nude Rag-2/Jak3No T cells, no B cells, no NK cells

From: Chapter 2, Mouse Models of Experimental Glioblastoma

Cover of Gliomas
Gliomas [Internet].
Debinski W, editor.
Brisbane (AU): Exon Publications; 2021 Apr 30.
Copyright: The Authors.

Licence: This open access article is licenced under Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) https://creativecommons.org/licenses/by-nc/4.0/

NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.