| Protease Class | Human | Mouse |
|---|---|---|
| SERINE | ||
| Tryptase-like | ||
| Active: | βI, βII, βIII, γ | mMCP-6, -7*, γ mastin/mMCP-11** |
| Inactive: Chymase-like | α, δ, β IIFS; mastin | mMCP-7* |
| Active: | CMA-1/α Cathepsin G | mMCP-1, -4, -5***; Cathepsin G |
| Inactive: | mMCP-2 | |
| Plasminogen activator | t-PA | ? |
| CYSTEINE/THIOL | ||
| Cathepsins | DPPI/C, ?others | DPPI/C, B, L, S |
| METALLO | ||
| Carboxypeptidase | CPA3 | CPA3 |
| Matrix metallo | MMP-9 | MMP-9 |
| ADAM, other | ? | ADAM17, neurolysin |
| ASPARTYL | Renin | Renin |
not expressed in some strains of laboratory mice
expressed primarily in basophils
elastolytic, not chymotryptic
From: MAST CELL PROTEASES AS PROTECTIVE AND INFLAMMATORY MEDIATORS
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