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Davis S, Martyn-St James M, Sanderson J, et al. A systematic review and economic evaluation of bisphosphonates for the prevention of fragility fractures. Southampton (UK): NIHR Journals Library; 2016 Oct. (Health Technology Assessment, No. 20.78.)

Cover of A systematic review and economic evaluation of bisphosphonates for the prevention of fragility fractures

A systematic review and economic evaluation of bisphosphonates for the prevention of fragility fractures.

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Appendix 7Table of excluded studies: cost-effectiveness review

TABLE 50

Studies excluded from the cost-effectiveness review and reasons for exclusion

CitationReason for exclusion
Jansen J, Gaugris S, Bergman G, Sen SS. P339. Cost-effectiveness of Fasavance® in the treatment and prevention of osteoporosis in the United Kingdom. Osteoporos Int 2006;17(Suppl. 1):S96Conference abstract
Liu H, Michaud K, Nayak S, Karpf DB, Owens DK, Garber AM. The cost-effectiveness of therapy with teriparatide and alendronate in women with severe osteoporosis. Arch Int Med 2006;166:1209–17Excluded interventions
Boonen S. Impact of treatment efficacy and dosing frequency on cost-effectiveness of bisphosphonate treatment for osteoporosis: A perspective. Curr Med Res Opin 2009;25:2335–41Systematic review
Botteman MF, Meijboom M, Foley I, Stephens JM, Chen YM, Kaura S. Cost-effectiveness of zoledronic acid in the prevention of skeletal-related events in patients with bone metastases secondary to advanced renal cell carcinoma: application to France, Germany, and the United Kingdom. Eur J Health Econ 2011;12:575–88Patients with renal cell carcinoma
Brandao CMR, Machado GPM, Acurcio FA. Pharmacoeconomic analysis of treatment strategies for osteoporosis in postmenopausal women: a systematic review. Rev Bras Reumatol 2012;52:924–37Systematic review
Cowell W, Koay A, Hunjan M. Economic analysis: ibandronate (Bonviva®) IV injection for the treatment of postmenopausal osteoporosis (PMO) in the UK. Value Health 2006;9:A380Conference abstract
Dell R, Greene D. Is osteoporosis disease management cost effective? Curr Osteoporos Rep 2010;8:49–55USA location
Fardellone P, Cortet B, Thomas T, Legrand E, Bresse X, Bisot-Locard S, et al. Cost-effectiveness simulation modeling of the compliance of 5 mg zoledronic acid once a year versus current treatments in post-menopausal osteoporosis. Value Health 2007;10:A395Conference abstract
Farquhar D, Pasquale M. Cost-effectiveness of risedronate versus ibandronate at one year: the case of the United Kingdom. J Bone Miner Res 2008;23:S212Conference abstract
Grima D, Borisov N. Cost-effectiveness of risedronate vs. generic alendronate: 1-year analysis among women 50–64 years old. J Bone Miner Res 2008;23:S212Conference abstract
Halperin M. The ethics of generics: medical and economic advantages of a generic alendronate in treating osteoporosis patients. Osteoporos Int 2006;17:S263Conference abstract
Hiligsmann M, Ethgen O, Bruyere O, Reginster J-Y. An economic evaluation of quantitative ultrasonometry as pre-screening test for the identification of patients with osteoporosis. Dis Manag Health Outcomes 2008;16:429–438Cost-effectiveness of a pretreatment scanning strategy
Hiligsmann M, Bruyere O, Ethgen O, Reginster J. Cost-effectiveness of bone densitometry screening combined with alendronate therapy for those who have osteoporosis. Value Health 2007;10:A236Conference abstract
Hiligsmann M, Kanis JA, Compston J, Cooper C, Flamion B, Bergmann P, et al. Health technology assessment in osteoporosis. Calcif Tissue Int 2013;93:1–14Systematic review
Jansen J, Gaugris S, Bergman G, Sen S. Cost-effectiveness of Fosavance® in the treatment and prevention of osteoporosis in the United Kingdom. Osteoporos Int 2006;17:S96Conference abstract
Jansen JP, Gaugris S, Bergman G, Sen SS, Jansen JP, Gaugris S, et al. Cost-effectiveness of a fixed dose combination of alendronate and cholecalciferol in the treatment and prevention of osteoporosis in the United Kingdom and the Netherlands. Curr Med Res Opin 2008;24:671–84Excluded interventions
Johnell O. Cost effectiveness of alendronate (fosamax) for the treatment of osteoporosis and prevention of fractures. PharmacoEconomics 2006;21:305–14Swedish location
Kanis J, Cooper C, Hiligsmann M, Rabenda V, Reginster JY, Rizzoli R. Partial adherence: a new perspective on health economic assessment in osteoporosis. Osteoporos Int 2011;22:2565–73Systematic review
Kanis JA, McCloskey EV, Jonsson B, Cooper A, Ström O, Borgström F. An evaluation of the NICE guidance for the prevention of osteoporotic fragility fractures in postmenopausal women. Arch Osteoporos 2010;5:19–48Excluded interventions
Kanis JA, McCloskey EV, Johansson H, Ström O, Borgström F, Oden A, et al. Case finding for the management of osteoporosis with FRAX–assessment and intervention thresholds for the UK. Osteoporos Int 2008;19:1395–408. [Erratum published in Osteoporos Int 2009;20:499–502]Very limited discussion of modelling
Kanis JA, Adams J, Borgström F, Cooper C, Jonsson B, Preedy D, et al. Modelling cost-effectiveness in osteoporosis. Bone 2008;43:215–16Response to a letter published previously in the same journal
Logman F, Heeg B, Botteman M, Marfatia A, van Hout B. Cost-effectiveness of zoledronic acid in the prevention of fractures in postmenopausal women with early breast cancer receiving aromatase inhibitor: application to the United Kingdom. EJC Suppl 2007;5:156Conference abstract
Logman F, Heeg B, Botteman M, Kaura S, van Hout B. Economic evaluation of zoledronic acid for the prevention of osteoporotic fractures in post-menopausal women with early breast cancer receiving aromatase inhibitors in the United Kingdom. Cancer Res 2009;69:S574Conference poster
Logman J, Heeg B, Botteman M, Kaura S, van Hout B. Economic evaluation of zoledronic acid for the prevention of osteoporotic fractures in post-menopausal women with early-stage breast cancer receiving aromatase inhibitors in the United Kingdom. EJC Suppl 2008;6:69–70Conference abstract
Logman JF, Heeg BM, Botteman MF, Kaura S, van Hout BA, Logman JFS, et al. Economic evaluation of zoledronic acid for the prevention of osteoporotic fractures in postmenopausal women with early-stage breast cancer receiving aromatase inhibitors in the UK. Ann Oncol 2010;21:1529–36Excluded intervention
Lynch N, Earnshaw S, Graham C, Middelhoven H. Cost-effectiveness of ibandronate injection IV in the treatment of UK women with postmenopausal osteoporosis who are intolerant to oral bisphosphonates. Osteoporos Int 2007;18:S11–12Conference abstract
Lynch N, Earnshaw S, Beard S, Cowell W. Ibandronate is cost-effective in the treatment of postmenopausal osteoporosis: a comparision of bisphosphonates. Osteoporos Int 2006;17:S11Conference abstract
Lynch N, Earnshaw S, Graham C, Patroe V, Boisdron J, Middelhoven H. Ibandronate IV injection is cost-effective in the treatment of UK women with postmenopausal osteoporosis who are intolerant to oral bisphosphonates. Ann Rheum Dis 2007;66:529Conference abstract
McLellan AR, Wolowacz SE, Zimovetz EA, Beard SM, Lock S, McCrink L, et al. Fracture liaison services for the evaluation and management of patients with osteoporotic fracture: a cost-effectiveness evaluation based on data collected over 8 years of service provision. Osteoporos Int 2011;22:2083–98Cost-effectiveness assessment of methods of treatment delivery with same pharmaceuticals use in both arms
Olson M, Brereton N, Huels J, Roberts D, Akerhurst R. Comparison of the cost-effectiveness of zoledronic acid 5 mg for the management of post-menopausal osteoporosis in the UK setting. Value Health 2007;10:A395–6Conference abstract
Rizzoli R, Akesson K, Bouxsein M, Kanis J, Napoli N, Papapoulos S, et al. Subtrochanteric fractures after long-term treatment with bisphosphonates: a European Society on Clinical and Economic Aspects of Osteoporosis and Osteoarthritis, and International Osteoporosis Foundation Working Group Report. Osteoporos Int 2011;22:373–90Systematic review
Rosenzweig A, Mishra R. Evaluation and management of osteoporosis and fragility fractures in the elderly. Aging Health 2009;5:833–50Review of osteoporosis, prevention and treatment, no economic aspect
Simbula S, Burchini G, Santarlasci B, Trippoli S, Messori A. Cost-effectiveness analysis of therapeutic or preventive interventions <not enough value for money>. G Itali Farmacia Clin 2008;22:86–105Full-text paper not in the English language
Stevenson MD, Oakley JE, Lloyd JM, Brennan A, Compston JE, McCloskey EV, et al. The cost-effectiveness of an RCT to establish whether 5 or 10 years of bisphosphonate treatment is the better duration for women with a prior fracture. Med Dec Making 2009;29:678–89Establishing optimum duration of treatment
Stevenson MD, Jones ML, Stevenson MD, Jones ML. The cost effectiveness of a randomized controlled trial to establish the relative efficacy of vitamin K1 compared with alendronate. Med Dec Making 2011;31:43–52Excluded interventions
Sunyecz J, Silberman C, Poston S, Earnshaw S. Cost-effectiveness of ibandronate therapy for women with postmenopausal osteoporosis with respect to nonvertebral fracture efficacy. J Bone Miner Res 2008;23:S213Conference abstract
Warde N. Prostate cancer: is fracture prevention therapy cost-effective in patients with prostate cancer treated with ADT? Nature Rev Urol 2010;7:363In-brief article
Copyright © Queen’s Printer and Controller of HMSO 2016. This work was produced by Davis et al. under the terms of a commissioning contract issued by the Secretary of State for Health. This issue may be freely reproduced for the purposes of private research and study and extracts (or indeed, the full report) may be included in professional journals provided that suitable acknowledgement is made and the reproduction is not associated with any form of advertising. Applications for commercial reproduction should be addressed to: NIHR Journals Library, National Institute for Health Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton Science Park, Southampton SO16 7NS, UK.

Included under terms of UK Non-commercial Government License.

Bookshelf ID: NBK390990

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