3UA4,7KID


Conserved Protein Domain Family
PRMT5

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pfam05185: PRMT5 
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PRMT5 arginine-N-methyltransferase
The human homolog of yeast Skb1 (Shk1 kinase-binding protein 1) is PRMT5, an arginine-N-methyltransferase. These proteins appear to be key mitotic regulators. They play a role in Jak signalling in higher eukaryotes.
Statistics
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PSSM-Id: 428356
Aligned: 30 rows
Threshold Bit Score: 231.325
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3UA4_B       349 DSTHYLNvIEYKDVLQAPLQPLSENLDSGVYNTFEQDQIKYDVYGEAVVGALKDLGADGRKTVv--------------IY 414 Caenorhabditis ...
Q5CY57       304 SSKQKYE-YNYIDVLQMPLQPLSNNLKSIEYEVFERDHIKYEKYFHAVKLFLSENNIKSEEIK---------------VL 367 Cryptosporidium...
XP_001609241 290 TEAEKFK-QGFYDVLQEPLQPVRDNLETATYENFERCTRKYAQYEAAISAWLKDYLNGKIGSQdenvrqdcgkskapvIY 368
Q4UG56       334 TIRELYG-RGYEDLFQVPLQPLRDNLDSSTYNEFEKCSFKYNCYDQAIHSFISTKLISLNQLSklnsnisysspvnyiVY 412 Theileria annulata
Q6C5F5       436 SALEKFS-DGYHDFLQAPLQPLADNLENGTYEAFEQDPVKYTLYEEAIGKALVHLVREKKSATgt-----------fmVC 503 Yarrowia lipoly...
Q75DB6       277 LLQAPGE--DGAPRVMQPLQPHAVDLSSEVYQIFEQDKTKYDLYAKAITAALRSIRSTMNKMWlhd---------dlnII 345 Eremothecium go...
Q6CT32       303 DVVHSA------PTIMPPLLPHHDNLSNAVYQVFEKDTVKYELYERAIMVAVSEILTENSSSWrgpt--------eliTL 368 Kluyveromyces l...
XP_001644616 311 ENDITIEdNYWIPRVMPPLLPNSENLSNLVYSNFERDTVKYELYQRAIELAVRDQIDYRRSYNl-------------vIL 377
Q6FX40       302 KMLKACE-KLAEPRILPQLKPHSEDLSNQTYALFEEDIVKYDLYEVAIKDAILENTKIWKNRGssf----------itIL 370 [Candida] glabrata
A0BU75       261 SEQAHLA-SEFFDELQIPLQPYKDNLNSGTYEVFEQDKIKYDLYEDACRKYLKNVKKAEi-----------------nIL 322 Paramecium tetr...
3UA4_B       415 LLGGGRGPIGTKILKSEREYNn-TfrqgqeslKVKLYIVEKNPNAIVTL--KYMNVRT---Wk---RR-VTIIESDMRSL 484 Caenorhabditis ...
Q5CY57       368 IVGSGRGGLIKSAFNAFSYIGi-N--------SFKIMCVEKNRNAVLTLk-AKMNYKDnanW----EK-VDIINSDIRTV 432 Cryptosporidium...
XP_001609241 369 IVGAGRGPLVDCSLRALAYHNv-E--------EYSIFALEKNPAAVFALk-HKIATNAikgW----DK-VQIIFHDMRTL 433
Q4UG56       413 VLGAGRGPLVEVVMEVFKRNNipTn-------DFVVFALEKNPYTMLTLd-HKIQNNR---W----TN-VRLIYSDMRDL 476 Theileria annulata
Q6C5F5       504 VAGAGRGPLVDRTIAAATTTK--T--------QVKIVAVEKNPAAYVQLm-QR-NNDV---WnaqgHR-VEVIMSDMRTY 567 Yarrowia lipoly...
Q75DB6       346 VVGAGRGGLVDRAYTCLRQLGi-S--------RFKLVALEKNPQAVIHLq-KK-NIEK---Wg---NS-VDIVSANMREW 407 Eremothecium go...
Q6CT32       369 VAGAGRGPLVDKTFQVLHKLGv-T--------NFRLLAIEKNPQALLYLq-KR-NFEH---Wd---NK-VEVIRTDIREW 430 Kluyveromyces l...
XP_001644616 378 IAGAGRGALVDRTFEVANFLNilN--------NVKIIALEKNPQACLYLq-KR-KFDS---Wg---EK-VEIIRDDMKKW 440
Q6FX40       371 VAGAGRGPLVDRVFKVLQELSilS--------ECRVIAIEKNSRAYLYLq-KR-NFDK---Wq---NR-VTLINEDIQNW 433 [Candida] glabrata
A0BU75       323 MAGAGRGGILERVIFAAQGAK--C--------KTKIVALEKNPYAYMTLvfQKKRQKQ---W-----KdVEIVLDDLKSW 384 Paramecium tetr...
3UA4_B       485 PGIAkdr----gfeQPDIIVSELLGSFGDNELSPECLDGVTG-----FLKPT-TISI 531 Caenorhabditis elegans
Q5CY57       433 QLDE----------KYDLIISELIGSFGDNELSPECLIFAQR-----FLKPS-GIMI 473 Cryptosporidium parvum
XP_001609241 434 KPTI----------PADLVLSELLGSFGDNELAPECLDGVQHafykaFPNHH-VTFM 479
Q4UG56       477 NRGMvqsnlnnaskTVHLVLSELLGSFGDNELSPECLYGFERsfnslFSQGVrLEFI 533 Theileria annulata
Q6C5F5       568 ESRSe--------qFFDLIISELLGSFGDNELSPESLDPIQR-----LLHPTrGIMI 611 Yarrowia lipolytica
Q75DB6       408 SSKV----------KFDLCISELLGSFGCNELAPECLEAFEK-----TNCTDrTIFI 449 Eremothecium gossypii
Q6CT32       431 DENI----------KVDLCISELLGSFGCNELSPECIAPIEA-----FHSKPnTRFI 472 Kluyveromyces lactis
XP_001644616 441 GDSSi---------KVDICISELLGSFGCNELSPECLFNIQK-----NHSKPsTIFI 483
Q6FX40       434 QINMaes----qrtKVDLCISELLGSFGCNELSPECLLSLQK-----YHSQKeTVYI 481 [Candida] glabrata
A0BU75       385 QTEL----------KFDLIVSELLGSFGDNELSPECLMWAQR-----FLQPD-AVSI 425 Paramecium tetraurelia
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