Conserved Protein Domain Family
CR6_interact
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pfam10147: CR6_interact 
Growth arrest and DNA-damage-inducible proteins-interacting protein 1
Members of this family of proteins act as negative regulators of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occur also in the absence of GADD45 proteins. Furthermore, they act as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity.
Links
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Statistics
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PSSM-Id: 431088
Aligned: 7 rows
Threshold Bit Score: 181.205
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_001345133  20 MAASLL-------SRRTASSfsftKLNSLLPAAVIQIANYNPRplrlNLKDPYIpdkesertpewQKTEKFERRLFGRYG 92 
Q9VP13        29 LPASLVgdv-dvePTYPQTV----DRSGLQPQHKNVLLNKLPY----QEPHSWI-----------HLTEKYQRQAFGRYG 88  fruit fly
XP_002021124  29 LPAAIInenvedsSVHARRL----NKSGLQEQHKNIVMGVPPY----RDAQSWI-----------HLTEKYQRKVYGLYG 89 
P90915        24 LVRSFA-------TNSSEEIapkvDVSFLRPRHRIIAAGGMPP----VQFDS-------------ERERASRRERFGKYG 79  Caenorhabditis ...
Q5XJW2         1 MAAP---------ATRSRYLlr--ltVTLGPRSRSYHAPPPPR----RRPAPHWpdrenlmtprwQLTPRYAAKQFGRHG 65  Norway rat
A1A4P4         1 MAAP---------VRQTRSLlg--wvTTLGPGSRGYRAPPPPR----RSREPWWpdpddpltprwQLGPRYAAKQFARHG 65  cattle
XP_309305     46 LPLTFVdddaestEAREARIaalrNKSRLLPQHRNMLHGVLPY----EQSQSWI-----------HDTVKYKRMMLGRYG 110 Anopheles gambi...

XP_001345133  93 RA-SGVNPVKLWPS-AARleelMAEEREWHPPVEQMLQNIAERQMEKEKRRIEREKTIA------ESMAKMPKLIADWKK 164
Q9VP13        89 AQ-SNVNPKICFDShGEK----DSRQVMQLETLLKMLEKNRAQKAEELARINAREEDIA------KKMEKLTQWKADLHA 157 fruit fly
XP_002021124  90 AK-SNVNPKICFDSkAEQ-------EVMQLDTFFKVLEKSRLEKAEKIQKTNDRDEDIA------KKLDKLEQWKSDLNA 155
P90915        80 LK-SGVPVEELFPT---------AEEIEEEEAIGLFREFNNAKKEYKELQKKKRESELAriaeleKNLKKYPATLAKYEA 149 Caenorhabditis ...
Q5XJW2        66 AI-SGVPPASLWPS-SEQlcelEAEEREWYPSLATMQESLRVQQQAAEARRQAREQHIA------ECMAKMPQMIENWRK 137 Norway rat
A1A4P4        66 AA-SGVDPGSLWPS-REQllelEAEEREWYPSLAVMQESLRVQQLAEEQKRQAREQLIE------ECMAKMPQMIENWRR 137 cattle
XP_309305    111 IDgSKVDPRVCFPTkKEAyeraEYERVAFPFSLKQMMDANESERKARKAQIEAREAEVA------RKLEKLDQWTADLNA 184 Anopheles gambi...

XP_001345133 165 QKREAKQKANEEKQKQVRLLAMARERFGFAVDPRSVKFKEMVAEIEKEEKKQRKLLKRQKKEEEQTSITPTADS 238
Q9VP13       158 KIAKREADAAAAIQRKERLVEEVRRHFGFKVDTRDERFKEMLEQKEKEDKKKQKEAKRKAKEEKMMAKLVEKAS 231 fruit fly
XP_002021124 156 KVAKREAEAAAAIARKERLVEEVRRHFGFKVDTRDERFKEMLEQKEKEDKKKQKEAKRKAKEEKMMAKLVEKTS 229
P90915       150 SLVKQEQEKDEKEVALEKRIRDIQEYFGYWMDPKDPRFEVMLQQKEAEEKKAVKMAKRDEIQKKRFAENVqg-- 221 Caenorhabditis elegans
Q5XJW2       138 QKRERWEKIQADKERRARLQAEAQEQLGYHVDPRSARFQELLQDLDKQQRKRLKEERQRQKKEARIAAMASAEG 211 Norway rat
A1A4P4       138 QQQARREKAQADKERRARLQAEAQERLGYHVDPRSARFQELLQDLEKQHRKRLKEEKQRKKKEARAAAMAAAAA 211 cattle
XP_309305    185 RIAKKEAEARAAKERKDRLVEEVRRHFGFKVDPRDERFQEMLALKEREDRKKVKEAKRKEKEEKMMEKLQKKTA 258 Anopheles gambiae str...
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