Conserved Protein Domain Family
NRK1
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cd02024: NRK1 
Nicotinamide riboside kinase (NRK) is an enzyme involved in the metabolism of nicotinamide adenine dinucleotide (NAD+). This enzyme catalyzes the phosphorylation of nicotinamide riboside (NR) to form nicotinamide mononucleotide (NMN). It defines the NR salvage pathway of NAD+ biosynthesis in addition to the pathways through nicotinic acid mononucleotide (NaMN). This enzyme can also phosphorylate the anticancer drug tiazofurin, which is an analog of nicotinamide riboside.
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Statistics
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PSSM-Id: 238982
Aligned: 38 rows
Threshold Bit Score: 163.65
Created: 20-Oct-2004
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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Active site
Feature 1:Active site [active site]
Evidence:
  • Comment:GxxxxGK[S/T], signature p-loop motif, also known as Walker A motif, present in various triphosphate nucleotide binding proteins. The Lys residue within the motif plays a major role in the phosphoryl transfer.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1           #    ####                                                                  
NP_014270    8 LVALSGCSSSGKTTIAKLTasl------------------ftkATLIHEDDFYkHDNEVPvdak---yniqNWDSPEAld 66   Saccharomyces ce...
XP_327939   10 VIGISGCSSSGKTTLARLLrdi------------------fpnTFILHEDDFYkPESEIPmke-----gltNWDCPEAls 66   Neurospora crassa
CAE72950     8 IFALAGCTNSGKSTLAKEFqrhf----------------gaaeTTIINQDEFYkTEDEVDki--------yHPAAVTLte 63   Caenorhabditis b...
NP_491763    8 VLALAGCTNSGKSTLAKEFqrff----------------gageTTIINQDEFYkTENEVEki--------yHPDAEHLtd 63   Caenorhabditis e...
NP_595603    7 IVGVSGASCSGKSTLCQLLhai------------------fegSSLVHEDDFYkTDAEIPvkn-----giaDWDCQESln 63   Schizosaccharomy...
EAA65126  1168 IFALSGPSSSGKTTLARLLqrifsnqpqtq---egsqlsklisTFIIHEDDFYySDDKIPytttksgariqDWDCLGAld 1244 Aspergillus nidu...
EAA72788     8 IVGISGCSSSGKTTLARLLrdi------------------fphTFILHEDDFYrPENELPtkn-----gllDWDCAEAid 64   Gibberella zeae ...
EAK87232    55 VVGVGGATCSGKTTLAKHLiqilnpladaagcssgshrggitdAFILHQDDFApPEATLPvnee---fgvtDWDHPPTa- 130  Ustilago maydis 521
EAA49440     8 LVGLSGCSSSGKTTLARLIrdi------------------fpnTFILHEDDFYkNESELPkra-----ghaDWDCVGSln 64   Magnaporthe gris...
EAL19422    12 IGIGRGASCSGKTLLAKHIrral-----------------ptdAAIIHQDDLCpPAEEVPyskqy--pdlqDWDDPETci 72   Cryptococcus neo...

Feature 1                                                                                      
NP_014270   67 f-klFGKELDVIKqtgk--iatkLIHNNnvddpftkfhidrqvw------------------------------------ 107  Saccharomyces ce...
XP_327939   67 i-pdMTAALEHIRatg----elpVSSTMnltrpflsrrhthgssstttssssyyppssssaaaskaappkqktgpgktit 141  Neurospora crassa
CAE72950    64 --rgYYWSFDEKEainidqfkerILQESkl-------------------------------------------------- 91   Caenorhabditis b...
NP_491763   64 --egYYWSFDEKEainidqfrqrILNESkv-------------------------------------------------- 91   Caenorhabditis e...
NP_595603   64 l-daFLENLHYIRdhgv--lpthLRNREnknvapealieyadi------------------------------------- 103  Schizosaccharomy...
EAA65126  1245 i-kfLTSALRYVHehgh--lpprLRSKEdlnevspgsgvddalvdelrgyvss--------------------------- 1294 Aspergillus nidu...
EAA72788    65 i-paMAESLAYIRqhaa--fpptLDSKEdqnsvgkcpvpdstinaqr--------------------------------- 108  Gibberella zeae ...
EAK87232   131 ---iQDAQIDYKRmygt---ikhIKSTGsfppeftshdhlnsqpdcpisetv---------------------------- 176  Ustilago maydis 521
EAA49440    65 i-eqMEKSLSYIRengq--fppdLNSIEdqnavgkcpvsdakiqelktk------------------------------- 110  Magnaporthe gris...
EAL19422    73 lwseFRALLRQVRetgh--vgdhDTHDHlnkenkievneqiferwq---------------------------------- 116  Cryptococcus neo...

Feature 1                                                                                      
NP_014270  108 ------------------------------------------------------delkakydsinddkyeVVIVDGFMIF 133  Saccharomyces ce...
XP_327939  142 takskslsnspkqptldskedlnsvgpcpittdfinkikarvadwlqpsspghrvlhlsshqqqqqqplkICIIDGFLLY 221  Neurospora crassa
CAE72950    92 --------------------------------------------------------------------fkNVIIDGNMIT 103  Caenorhabditis b...
NP_491763   92 --------------------------------------------------------------------ykNVIIDGNMIT 103  Caenorhabditis e...
NP_595603  104 -------------------------------------------------------ikefkapaiptleqhLVFVDGFMMY 128  Schizosaccharomy...
EAA65126  1295 ---------------------------------------------rtqmillssssmvaeerldgkekvtIALLEGFLLY 1329 Aspergillus nidu...
EAA72788   109 ----------------------------------------------------akvdaalgpdhplrnnlrLCLLDGFLLY 136  Gibberella zeae ...
EAK87232   177 -----------------------------------------------sktwkdkfgsltslntfsagdvrILLADGFLLY 209  Ustilago maydis 521
EAA49440   111 -------------------------------------------------vaewskpdgpghgllvpgdlgLCLLDGFLLY 141  Magnaporthe gris...
EAL19422   117 ----------------------------------------------------rrfeeltkqqreqgveliWVIVDGFVLY 144  Cryptococcus neo...

Feature 1                                                                                      
NP_014270  134 NNtgis------------kkfDLKILVRApyevLKKRRASRKGYqtld-------------------------------- 169  Saccharomyces ce...
XP_327939  222 SPppllpa-------tllsqmDIKLFLLVskakALQRREARDGYvtle-------------------------------- 262  Neurospora crassa
CAE72950   104 EMdeiv------------elcDQIVVLTLdfktCRRRREARTDYv----------------------------------- 136  Caenorhabditis b...
NP_491763  104 EMdeiv------------dlcDRIVVMTLdfktCKRRREARTDYv----------------------------------- 136  Caenorhabditis e...
NP_595603  129 VNedli------------nafDIRLMLVTdfdtLKRRREARTGYitle-------------------------------- 164  Schizosaccharomy...
EAA65126  1330 APpatekggkehglrgvhdqiDLPMFLAApydlVKERREKRSGYvtigpapttelpqrsssaseaeeervdleveddrpp 1409 Aspergillus nidu...
EAA72788   137 SPsmaav----------kpnlDIKLFLRTtyakAKARREARDGYvtle-------------------------------- 174  Gibberella zeae ...
EAK87232   210 YDpdvr------------stmDVKVFLRTpraiLRQRREERFGYatae-------------------------------- 245  Ustilago maydis 521
EAA49440   142 TPplkhi----------msllDLKFFLLVsratAIRRREARIGYvtve-------------------------------- 179  Magnaporthe gris...
EAL19422   145 YDkdvv------------dmlDIRIFLRVphdvLKDRREERQVYvlqr-------------------------------- 180  Cryptococcus neo...

Feature 1                                    
NP_014270  170 -sfwVDPPYYFDEFVYESYRANHAQLFVNG 198  Saccharomyces cerevisiae
XP_327939  263 -gfwKDPPGYVEKIVWPEYVRAHEWMFEGG 291  Neurospora crassa
CAE72950   137 ---pPDTPGYFENVAFPAYLRHLENARKRS 163  Caenorhabditis briggsae
NP_491763  137 ---pADTPGYFVNVAFPAYVRHLERARQRS 163  Caenorhabditis elegans
NP_595603  165 -gfwQDPPHYFENYVWPGYVHGHSHLFVNG 193  Schizosaccharomyces pombe
EAA65126  1410 qnfwTDPPGYVDDIVWPRYVRDHAWLLLPE 1439 Aspergillus nidulans FGSC A4
EAA72788   175 -gfwADPPGYVDKIVWPNYVEEHAWMFEDG 203  Gibberella zeae PH-1
EAK87232   246 gtvwKDPEGYFDNIVWPAYELAHKGVFSNH 275  Ustilago maydis 521
EAA49440   180 -gfwADPEGYATDVVWPNYAESHAWLFKDG 208  Magnaporthe grisea 70-15
EAL19422   181 -gvwIDPPEYFNKIVWPGYLKAHAHVFEDP 209  Cryptococcus neoformans var. neoformans B-3501A

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