Conserved Protein Domain Family
MFS_SLC17

?
cd17318: MFS_SLC17 
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters
The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Statistics
?
PSSM-Id: 340876
Aligned: 27 rows
Threshold Bit Score: 358.085
Created: 28-Jul-2008
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
 
putative
Feature 1:putative chemical substrate binding pocket [chemical binding site]
Evidence:
  • Comment:based on the structures of MFS transporters with bound substrates, substrate analogs, and/or inhibitors
  • Comment:since MFS proteins facilitate the transport of many different substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides, the residues involved in substrate binding may not be strictly conserved among superfamily members
  • Comment:the substrate binding site or translocation pore has access to both sides of the membrane in an alternating fashion through a conformational change of the MFS transporter

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                  ##  ##  #                                                             
Q9NRA2        43 AILAFFGFFIVYALRVNLSVALVDMVdsnttlednrtskacpe-----hsapikvhhnqtgkkyqWDAETQGWILGSFFY 117 human
O16923        57 SIMLCFCFGCVHLMNSNMGMAIVCMVnssatydnet-------------------ypenaaplldWSSDEQGYIFSAFNA 117 Caenorhabditis ...
Q9V7S5        44 TFMLFLGMANAYVMRTNMSVAIVAMVnhtaiksgeaeeyddec------gdrdipiddsqdgefaWSSALQGYILSSFFY 117 fruit fly
Q14916        23 SFLVHCCNVIITAQRACLNLTMVVMVnstdphglpntst-------------kklldniknpmynWSPDIQGIILSSTSY 89  human
NP_620115     24 AIMGFLAILNAYTMRVCLSQAITVLVvkknstdddseaice---------pddidegtsvggdfeWSEELQGLILSSFYI 94  fruit fly
NP_725829     27 CILCFFCLAMSYAWRVNLSVALVAMTdnstslaqnntntgva-------psepgfdffnseryynFTQKEKGNLQASFFF 99  fruit fly
NP_572857     72 GFMGFLGFAVVYAMRVNLSVAIVAMVnqtaiphsnssvidtdtcplpaphhngsdpnpqkegefvWDEATQGLVLGSFFY 151 fruit fly
Q9BYT1        27 TGTLLLGTCLLYCARSSMPICTVSMSqd-----------------------------------fgWNKKEAGIVLSSFFW 71  human
NP_611375     31 CILVFFGLAVAYSLRVNLSVAIVAMTdrnasnp--------------------------dfpefdWNESTKSYLLSSFFW 84  fruit fly
NP_001091956  42 ALVLHFCNFTTIAQNVIMNITMVAMVnstspqsqlndssevlpvdsfgglskapkslpakapvydWSPQIQGIIFGAVGY 121 human
Feature 1             #                                                      ## ###  #           
Q9NRA2       118 GYIITQIPGGYVASKIGgKMLLGFGILGTAVLTLFtpiaad---lgvgpLIVLRALEGLGEGVTFPAMHAMWSSWApple 194 human
O16923       118 GLLVMLFTGGMADKFNA-KYMILVSVAIASLANFTlpwmap---isvywAIFSRFLVGFADALLQPAMNSLITRWFptse 193 Caenorhabditis ...
Q9V7S5       118 GYVITQIPFGILAKKYGsLRFLGYGMLINSVFAFLvpvaar--gggvwgLCAVRFIQGLGEGPIVPCTHAMLAKWIppne 195 fruit fly
Q14916        90 GVIIIQVPVGYFSGIYStKKMIGFALCLSSVLSLLippaag---igvawVVVCRAVQGAAQGIVATAQFEIYVKWApple 166 human
NP_620115     95 GYIVTHIPGGLLAEKFGgKWTLGLGILSTAVFTMLtplain--kgdsdwLIVTRVLMGLGEGTTFPALSVLLAAWVpane 172 fruit fly
NP_725829    100 GYIVTQVPGGYIAQRYGaKTMLMYGLGIAALITMLspmslq---fgwvaLAVMRFVMGLAQGAVHPATHALLAKWSpade 176 fruit fly
NP_572857    152 GYVLTQVPGGRMAELYGgKKIYGYGVLITAVFTLItplaah---wdlplLVLVRILEGMGEGVTYPAMHAMLAHWIpple 228 fruit fly
Q9BYT1        72 GYCLTQVVGGHLGDRIGgEKVILLSASAWGSITAVtpllahlssahlafMTFSRILMGLLQGVYFPALTSLLSQKVrese 151 human
NP_611375     85 GYVVTQIPGGYLSAIYGaKYMLFYGVLICSCLALLtpfcav--nggwtvVVVLRAVQGLCQGVIFPSTHTFLSKWApaee 162 fruit fly
NP_001091956 122 GGILTMAPSGYLAGRVGtKRVVGISLFATSFLTLCiplatd---fgivlLIVTRIVQGLSQSSILGGQFAIWEKWGppqe 198 human
Feature 1                #  ##  #                                                                
Q9NRA2       195 rskllsiSYAGAQLGTVISLPLSGIIcyy----mnWTYVFYFFGTIGIFWFLLWIWLVsdtpqkhkrishyekeyils-- 268 human
O16923       194 rsyalglATGGRQIGTLIIIPAAGALcsqteifggWPSIFYLSGFIGVLFIFSYIFLGadkpskqscisdnelkfitisn 273 Caenorhabditis ...
Q9V7S5       196 rsrmgaaVYAGAQFGTIISMPLSGLLaeyg-fdggWPSIFYVFGIVGTVWSIAFLIFVhedpsshptiderekkyinds- 273 fruit fly
Q14916       167 rgrltsmSTSGFLLGPFIVLLVTGVIces----lgWPMVFYIFGACGCAVCLLWFVLFyddpkdhpcisisekeyitss- 241 human
NP_620115    173 rgklgalVLGGGQVGTIMGNLLSGVFida----ygWEFVFYFFGGLGVVWFAIFMFLCysdptshpfikpsereylvke- 247 fruit fly
NP_725829    177 rgmlgtlCYSGAQFGTVVMLATSGFIads---vlgWPSIFYLGGACGFIWMVFWYLFSastpeehrlispgelkyitdsr 253 fruit fly
NP_572857    229 rnkfaaiVYAGSNIGTVISMPLAGWLcsld-flggWPSAFYIFGLLGILWFIAWMYLVydkpsdhprisesereyiersl 307 fruit fly
Q9BYT1       152 raftysiVGAGSQFGTLLTGAVGSLLlew----ygWQSIFYFSGGLTLLWVWYVYRYLlsekdlilalgvlaqsr----- 222 human
NP_611375    163 rgrlvgyTYSGSQFGTVVMLSVSGYIass---slgWPSTFYIPGCVGIVWSFVWLYLCsstpaqhptitpnerrfiessg 239 fruit fly
NP_001091956 199 rsrlcsiALSGMLLGCFTAILIGGFIset----lgWPFVFYIFGGVGCVCCLLWFVVIyddpvsypwistsekeyiiss- 273 human
Feature 1                                                         #  ##  ###  #                  
Q9NRA2       269 --------------------slrnqlssqksvpwvpilksLPLWAIVVAHFSYNWTFYTLLTLLPTYmkeilrfnvqeNG 328 human
O16923       274 ------------------qsedvgkkrterkvpwknilksGAVWASVISLVCHEFPLMTLIMFLPSYlhdvhhyhsteNG 335 Caenorhabditis ...
Q9V7S5       274 --------------------lwgtdvvksppipfkaiiksLPFYAILFAHMGHNYGYETLMTELPTYmkqvlrfslksNG 333 fruit fly
Q14916       242 --------------------lvqqvsssrqslpikailksLPVWAISTGSFTFFWSHNIMTLYTPMFinsmlhvnikeNG 301 human
NP_620115    248 -------------------igtisrnedlpptpwkailtnLPMFALVAAQIGHDWGFYIMVTDLPKYmadvlqfsikaNG 308 fruit fly
NP_725829    254 ------------------sdgkmqsaeklaptpwkaifssLPFLSLLVVHCTHIFGYWLLLMQIPTYmkkiyhvdikkGA 315 fruit fly
NP_572857    308 qvqrlinqdlaeaeeeegqdevslrappeepipwsslltsVPLWAILLTQCGQGWAFYTQLTELPTYmsnilhfdiqsNA 387 fruit fly
Q9BYT1       223 ------------------------pvsrhnrvpwrrlfrkPAVWAAVVSQLSAACSFFILLSWLPTFfeetf--pdakGW 276 human
NP_611375    240 qa--------------rrpsdagreeqprpptpwwriftsVPFLVLVLAHCANNWGFWTLLTEIPTFmknvlgmdiknNG 305 fruit fly
NP_001091956 274 --------------------lkqqvgsskqplpikamlrsLPIWSICLGCFSHQWLVSTMVVYIPTYissvyhvnirdNG 333 human
Feature 1                 #   #                                                              ##  
Q9NRA2       329 FLSSLPYLGSWLCMILSGQAADNLrakwn-fstlCVRRIFSLIGMIGPAVFLVAAgf---igCDYSLAVAFLTISTTLGG 404 human
O16923       336 ILSALPTVSLWFAKIGSSYLNTWLqkntt-wkkdTICKVLNSIGSIGLGVFLLAAtfl--dnEHAWMAVLFLCLSMASAG 412 Caenorhabditis ...
Q9V7S5       334 LLSSLPYLAMWLFSMFISVVADWMisskr-fshtATRKLINSIGQYGPGVALIAAsy---tgCDRALTLAILTIGVGLNG 409 fruit fly
Q14916       302 FLSSLPYLFAWICGNLAGQLSDFFltrni-lsviAVRKLFTAAGFLLPAIFGVCLpy---lsSTFYSIVIFLILAGATGS 377 human
NP_620115    309 LYSSLPYVMMWIVSVGSGFVADWMirrgv-lsttNTRKVMTGLAAFGPAIFMVGAsy---agCDRVLVVVLFTICMGLMG 384 fruit fly
NP_725829    316 LLSSLPYMVMLLLSFFFVWLSKVLqkkeg-mslsFNRKIFNSIGHWIPMLSLIALgyv--paDNAPLAVTLLTLTVGISG 392 fruit fly
NP_572857    388 LLNAVPYLTSWFVGIACSALADWMlarry-isllNSYKLWNTVASVVPSLGLIGIiy---vgCDWVWVTFMLAGVGSFGG 463 fruit fly
Q9BYT1       277 IFNVVPWLVAIPASLFSGFLSDHLinqg--yraiTVRKLMQGMGLGLSSVFALCLgh----tSSFCESVVFASASIGLQT 350 human
NP_611375    306 PLSALPYFAMILLTCVFIWLSDTLkqrgtviplgFSRKFFNTLGMWLPMLALIGLgyitegeANVRLAIGLLTAAVATNS 385 fruit fly
NP_001091956 334 LLSALPFIVAWVIGMVGGYLADFLltkk--frliTVRKIATILGSLPSSALIVSLpy---lnSGYITATALLTLSCGLST 408 human
Feature 1         #   #               #  ##  ##  #                                            
Q9NRA2       405 FCSSGFSINHLDIAPsyaGILLGITNTFATIPGMVGPVIAKSltpdn---tvgeWQTVFYIAAAINVFGAIFFTLFA 478 human
O16923       413 LHTPGCQLALVSVAPaysGAVTGFTFFFVAVSGIIHPIITKMivkdr---taaeWNLVFYISTVIAIFPIIIFNVWG 486 Caenorhabditis ele...
Q9V7S5       410 GIYSGFKINHLDLTPrfaGFLMSITNCSANLAGLLAPIAAGHlisdpskpmmgqWQIVFFIAAFVYIICGTFYNIFG 486 fruit fly
Q14916       378 FCLGGVFINGLDIAPryfGFIKACSTLTGMIGGLIASTLTGLilkqd---pesaWFKTFILMAAINVTGLIFYLIVA 451 human
NP_620115    385 AYYAGMKLSPLDMSPnyaGTLMAITNGIGAITGVITPYLVGVmtpna---slleWRLVFWVAFGVLCFTAVIYCIWA 458 fruit fly
NP_725829    393 ATYLGFQVNHIDLSPnyaGTLMGITNCAANVMSGIAPVIVGQivvde--tsvteWRLVFLLAAAFYFLGNLLFVIFG 467 fruit fly
NP_572857    464 AVYAGNQMNHIALSPryaGTMYGITNSAANICGFLAPYVIGLiinhr--etltqWHLVFWLAAGLNIAGNFIYLIFA 538 fruit fly
Q9BYT1       351 FNHSGISVNIQDLAPscaGFLFGVANTAGALAGVVGVCLGGYlmet-----tgsWTCLFNLVAIISNLGLCTFLVFG 422 human
NP_611375    386 ATYLGFHVNHIDLSPnyaGTLMGITNCAANFMSILAPLIVGLivwde--tnpaqWRIVFFFTAFVYFIGNLLFMLFG 460 fruit fly
NP_001091956 409 LCQSGIYINVLDIAPrysSFLMGASRGFSSIAPVIVPTVSGFllsqd---pefgWRNVFFLLFAVNLLGLLFYLIFG 482 human

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap