Conserved Protein Domain Family
LC-FACS_euk

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cd05927: LC-FACS_euk 
Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
The members of this family are eukaryotic fatty acid CoA synthetases that activate fatty acids with chain lengths of 12 to 20. LC-FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions. Organisms tend to have multiple isoforms of LC-FACS genes with multiple splice variants. For example, nine genes are found in Arabidopsis and six genes are expressed in mammalian cells.
Statistics
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PSSM-Id: 341250
Aligned: 24 rows
Threshold Bit Score: 711.679
Created: 2-Nov-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:putative active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                        
NP_001012596 117 QPYEWISYKEVSDRAEYVGSALLHRGfkp---------shSQYVGIFAqNRPEWVIIEQSCytYSMVVVPLYDTLGtEAI 187 chicken
AAW82720      82 GAYSFMTYKQVETFALLIGSALSQLLiepqvse-dptvkdARMVGLFVpNCLEWLILEQACnaYAYTLVPIYNTLGhESI 160 Babesia bovis
EDQ74001      74 GAYVWKSYEQVYDNVLQIGSAMRYVGvn-----------pKGHCGIYGmNCPEWFTAMEACnaQSIVCVPLYDTLGlTAV 142 Physcomitrella ...
NP_501893    110 LEWEWISYDQAFETSDHASQAIRKLGiei---------geESKIGIYSnNRPEWILSEMAIhnFSNVSVPLYDTITnDDM 180 nematode
AAW82719      77 GEYVFKSYKEVESLVQRFGSGLRSLKgvnkvevlapepveATMIGIYAsNCVEWLICEQTCngYGYTIVPIYDTIGeESI 156 Babesia bovis
NP_503540     67 GRHVYTTYREAVEEATIIGSGIVAIMqkn--------qstNKLIGIAGiHSRKYMHTMHGIsgFDLTTVPLYHQSKlETL 138 nematode
Q1ZXQ4        94 GKFEWISYNTYLERCEYIQQGLCELGlk-----------pKSKVGIFSkNRLEWLIVHSASfiQSYCVVSFYETLGvESL 162 Dictyostelium d...
NP_182246     72 GPYMWKTYKEVYEEVLQIGSALRAAGae-----------pGSRVGIYGvNCPQWIIAMEACaaHTLICVPLYDTLGsGAV 140 thale cress
NP_175368     75 GPYTWITYKEAHDAAIRIGSAIRSRGvd-----------pGHCCGIYGaNCPEWIIAMEACmsQGITYVPLYDSLGvNAV 143 thale cress
XP_001351807  76 GAYQWKNFGEVKELIMKVGSGLLNMNacplimcddqripkARFLGLYMpNCPEWNICDLGCnaYNIITVPLYDSLGpQSS 155 Plasmodium falc...
Feature 1                                                                                        
NP_001012596 188 TYIVNKADLSLVFCDTpekakllltavekgetpilstivimepfgtdllergkkcGVEVFSMKEIEELGKAhrq--kpiL 265 chicken
AAW82720     161 HTILLNSRISVLLCTPdtvkimftvleqgtegvelktiiliesdkvpdefaenkyGFKFILWKDLEEMGKNaql--pvsP 238 Babesia bovis
EDQ74001     143 EYILNHAEIEIAFAQEtklplimkslpncttflkt--lvsfgavtsdqrskgqdaGVTIYAWQDFLDLGKKnkc--dvtP 218 Physcomitrella ...
NP_501893    181 HYITNLCEISLMFVDAeiktkqlirdksylsslky--ivqfnecsddikemarenDFRLWSFNEFVEMGKKqkhr-phvP 257 nematode
AAW82719     157 IHILENSDINIVVCDPacaeklarvlpkamsht-----ikviivigtnkemiqttDIPVYLFSEILDMGDKali--pfeP 229 Babesia bovis
NP_503540    139 CDIIDNCKLEIIFCENakraegflssklgdrlrs----lktliildktttlqkhdDVEVMSLDEFKEIGKRnkr--npvK 212 nematode
Q1ZXQ4       163 SYVTEHAEIGLAFCSAetlqktldiakgvkvlkt---iicfdsidkehyniakelGVTLYTYDEIMKKGKEangkhkhtP 239 Dictyostelium d...
NP_182246    141 DYIVEHAEIDFVFVQDtkikgllepdckcakrlka--ivsftnvsdelshkaseiGVKTYSWIDFLHMGREkpe--dtnP 216 thale cress
NP_175368    144 EFIINHAEVSLVFVQEktvssilscqkgcssnlkt--ivsfgevsstqkeeaknqCVSLFSWNEFSLMGNLdea--nlpR 219 thale cress
XP_001351807 156 RFILDQTQMETIVCDKtcarnlfksletceeiylk-tlilvdeiddeikkecskyNLKIILWEELIKQGEKkiv--kvpQ 232 Plasmodium falc...
Feature 1                   #                                             ##                     
NP_001012596 266 PKPEDLAVICFTSGTTGNPKGAMITHKNIVSNSSAFLKTtektf--iptpEDVLISFLPLAHMFERIVECVVLCHGARIG 343 chicken
AAW82720     239 AEPDHLALISYTSGTSGVPKGVMITQANITNLIVVTCEEhvkrs-fpenpFERHISYLPMAHLFEKNFVNAVYYSGGCIG 317 Babesia bovis
EDQ74001     219 PKKEDLSTIMYTSGTTGEPKGVMLTHENVVNTIAGLDWYlksln-evmnkDDVYFSFLPLAHIFDRVAEEMFVFIGGSIG 297 Physcomitrella ...
NP_501893    258 PTPETLATISFTSGTTGRPKGVMLTHLNMCSATMSCEEFene-----agvQDAYLSYLPLAHIYERLCLLSNFMIGSRIG 332 nematode
AAW82719     230 ATPAMINTISYTSGTSGIPKGVILTQGQMASLIVVVNHVvgelngisvdaVKCYLSYLPLAHMYERLYIDSSLFVGGKIG 309 Babesia bovis
NP_503540    213 PKPETTYVICHTSGTTGRPKGVEMSHGSLVTSVSGIFTSwtiaykwkfglEDTYFSFLSLAHIYEHLIQTLTIYFGGKIG 292 nematode
Q1ZXQ4       240 PTPDTLSTIMYTSGTTGPPKGVMITHKNLTSVVCAVSDFikv------ydTDVHYSYLPYAHVLERVVILAAFHFGAAIG 313 Dictyostelium d...
NP_182246    217 PKAFNICTIMYTSGTSGDPKGVVLTHQAVATFVVGMDLYmdqfe-dkmthDDVYLSFLPLAHILDRMNEEYFFRKGASVG 295 thale cress
NP_175368    220 KRKTDICTIMYTSGTTGEPKGVILNNAAISVQVLSIDKMlevtd-rscdtSDVFFSYLPLAHCYDQVMEIYFLSRGSSVG 298 thale cress
XP_001351807 233 GALNNIFSICYTSGTTGYPKGVIMTNRNFIGILAAAYIGpsrlpdlcineNDIHISYLPLAHIYERLMIYLFMAHGVKVG 312 Plasmodium falc...
Feature 1                               # ##  #                      ##                          
NP_001012596 344 FFQgdirlLMDDLKTLQPTVFPVVPRLLNRMFDKIfg--qADTSLKKWMLDFASKRKeaelrsg--iirnnsfWDKVIFR 419 chicken
AAW82720     318 LYSgditkLLDDVQELKPTFFLGVPRLFQRIHDRImadvqRRGIIKRTLFNVALNHKinnleen--hsysslfWDRVVFN 395 Babesia bovis
EDQ74001     298 FWQgdikkVPEDIKELKPTLFVGVPRVFDRLTTGIqekiaASGRIKNWLFQIGFSMKlfwlkkgykqdqaspfFDKLVFD 377 Physcomitrella ...
NP_501893    333 FSRgdpklLVDDVQALAPRSFATVPRVIDKIHKAVmk-qvQDKPLKKMILNAAIAYKlyhykmtg-katrktwVDKYVLH 410 nematode
AAW82719     310 VYSgdvrnILDDLETLKPTVFVSVPRLFFRIHDKVfanvsRKPWFIRWLFNTALNSKvnrlrnt--gnckhrfWDKIVFK 387 Babesia bovis
NP_503540    293 IYDgntatLIPQIQKLEPTIVSLVPRLLNKLYEAVhdgvaKKGFIARKLFDYAKKTKarqlqrg--vlrydtfFDKIVFK 370 nematode
Q1ZXQ4       314 IFSgdisnILVEVKLLSPTLFIGVPRVFERIKTNVfkeisKKPALLRTLFNGAYNLKylsiqhgfklpiiekvLDLVFFS 393 Dictyostelium d...
NP_182246    296 YYHgnlnvLRDDIQELKPTYLAGVPRVFERIHEGIqkalqELNPRRRFIFNALYKHKlawlnrgyshskaspmADFIAFR 375 thale cress
NP_175368    299 YWRgdiryLMDDVQALKPTVFCGVPRVYDKLYAGImqkisASGLIRKKLFDFAYNYKlgnmrkgfsqeeasprLDRLMFD 378 thale cress
XP_001351807 313 YYSgnvqtLLEDIQELKPTLFISVPRLYNRIHERIfnslkKKSGLVQSLFNKGLQNKikrlsss--gstthvlWDKLLFN 390 Plasmodium falc...
Feature 1                                             ######                                     
NP_001012596 420 KIQASLGGKVRLMVTGAAPVSASVLTFLRtalGCQFYEGYGQTECtAGCSLSMPGDWt-AGHVGAPMACNIIKLVDVQEM 498 chicken
AAW82720     396 KMKKLLGGEVRWMFVGSASMNPEIIKRLRaifGVPLLWGYSLTECcAGTTAQNFYDTd-PTECGGPIPNQVYRVRSLPDM 474 Babesia bovis
EDQ74001     378 KVKMGLGGRVRLVISGAAPLSGHVEKFLRvimCAPVMQGYGLTETcAASFLQVPDVIsmNGTVGPPQPIIDVRLESVPEL 457 Physcomitrella ...
NP_501893    411 KIQMLLGPNIRQLILGAAKSDVSAMRFARgafGVEVLEGYGQTETsGPTTLQLVGDTr-IGCVGPPMACAMIKLIDVPEL 489 nematode
AAW82719     388 RFPALFGGNVRWMMTGSAPLAPRTYDRIRaifGTELLSGYGLTETaAGAVMNRQGETd-TTHVGGIIPTLEFRLKSLPEF 466 Babesia bovis
NP_503540    371 KLKLMLGGKLKVLTSGGAPITKEVKTFTRyayGCPLVEGYGQTECsAAGTLTLPWDTt-YGNVGGPAPWAQVKLVDVPEK 449 nematode
Q1ZXQ4       394 KIKQALGGKVRVILSGSAPLSFDTEVFLRvvmCCCVLQGYGASEGcGGDACKRLDDEs-VGTIGPPFASNEIKLVDVPEL 472 Dictyostelium d...
NP_182246    376 KIRDKLGGRIRLLVSGGAPLSPEIEEFLRvtcCCFVVQGYGLTETlGGTALGFPDEMcmLGTVGIPAVYNEIRLEEVSEM 455 thale cress
NP_175368    379 KIKEALGGRAHMLLSGAAPLPRHVEEFLRiipASNLSQGYGLTEScGGSFTTLAGVFsmVGTVGVPMPTVEARLVSVPEM 458 thale cress
XP_001351807 391 KAKKILGGHVRAMLNGSAPISVDVVKKLRtifCVPMFEGYGMTESlGASFITHSQDRn-IGHIGGPVPCIEFKLVSVPEM 469 Plasmodium falc...
Feature 1                                                      #           #  #        ####      
NP_001012596 499 NYLAa---kGEGEVCVKGPNVFLGYLKDPEKTAEal-dkDGWLHTGDIGKWLPNGTLKIIDRKKHIFKLAQGEYIAPEKI 574 chicken
AAW82720     475 EYDAea-pnPRGELLIRGNSVMKGYYRNPKATSEti--vDGWLHTGDVVEIQPSGAIRIIDRVKNVFKLAQGEYVSPELV 551 Babesia bovis
EDQ74001     458 GYDAlredsPQGEICIRGKTLFSGYYKRPELTEEvl--iNGWFHTGDIGEWQKDGALKIIDRKKNIFKLSQGEYVAVENL 535 Physcomitrella ...
NP_501893    490 GYSVd---kNGGEVLVKGHNVTSGYYKNPEATASsf-teDGYMKTGDIGRFTAEGSLQIIDRRKNVFKMPQGKFVAPDLT 565 nematode
AAW82719     467 EYSVkd-enPRGEIMFRGEHVTCGYFRNPEATAEaf--vDGWLLTGDIAELLPNGAIKIIDRRKNLFKLVQGEYISPEKL 543 Babesia bovis
NP_503540    450 NYFSm---nDEGEVCFRGNAMMTGYFQDPELTAKti-dsEGWLHTGDIGKWLPTGGLQIIDRKNEMFKLSQGDFVSPIQI 525 nematode
Q1ZXQ4       473 GYDSng-evQTGEVCLRGPSISSGYYKDEEKTREef--kDGWFHTGDIGRWNRDGSLSIVDRKKNIFKLSQGEYVAVEKI 549 Dictyostelium d...
NP_182246    456 GYDPlg-enPAGEICIRGQCMFSGYYKNPELTEEvm--kDGWFHTGDIGEILPNGVLKIIDRKKNLIKLSQGEYVALEHL 532 thale cress
NP_175368    459 GYDAfsadvPRGEICLRGNSMFSGYHKRQDLTDQvl--iDGWFHTGDIGEWQEDGSMKIIDRKKNIFKLSQGEYVAVENL 536 thale cress
XP_001351807 470 NYLVtd-npPKGELYLRGPSTCNLGYFKLEKETNellekDGFIRTGDIALLSPNGSLTIIDRKKNIFKLAQGEYVAVEKV 548 Plasmodium falc...
Feature 1                                                                                      # 
NP_001012596 575 ENVYLRSEALAQVFVHGESLQAFLLAVVVPDPETLCKWakkk--gfegTYEKLCKNkDVKKHILEDMVRVGKESGLKsFE 652 chicken
AAW82720     552 ESIISLSPLVAQSFVYGDSHQVAPVAIVIPDEDVINRWkgeng-mesmSFKDVCRTpELRKAILEDITRLFDENRLRgFE 630 Babesia bovis
EDQ74001     536 ENVYNESSSVDAIWVYGNSFESFLVAVAVPNQQALENWansn--geegDYATLCKSpKAQKFILSELTNMGKKKGLKgFE 613 Physcomitrella ...
NP_501893    566 ESLYTSSSFVQQIYVHGDMEKPWLVAIVVPDPEYLASYaltkhningkTYEQLCNIpILADDVLRQFVELTEEDKRPrYE 645 nematode
AAW82719     544 EAVLIGCALISQAFVTGKSTEVYPVAIVVPDETEAQYWaesqg-hgdmTLQDICQHpVFKEAIMEQMAQAYDEANVKgFE 622 Babesia bovis
NP_503540    526 EAIYANSPLITQIYVTGKTERSFLVGIVVLDLPRFKQLplvkaldgkeSIEMIMENkEVKNAVIAELNKYAKQNGLQtIE 605 nematode
Q1ZXQ4       550 ETIVVKSEYVEQVCIYGDSQKSCVIAIIHPHPESCSEWagsk--ktdkDIKEICKNqDFIKVVLDDIIKNCKKSGLHgFE 627 Dictyostelium d...
NP_182246    533 ENIFGQNSVVQDIWVYGDSFKSMLVAVVVPNPETVNRWakdl--gftkPFEELCSFpELKEHIISELKSTAEKNKLRkFE 610 thale cress
NP_175368    537 ENTYSRCPLIAQIWVYGNSFESFLVGVVVPDRKAIEDWaklny-qspnDFESLCQNlKAQKYFLDELNSTAKQYQLKgFE 615 thale cress
XP_001351807 549 EASYKQSLFISQIFVFGYSYESVLVCVICPSTDSIDIWrtqk--kikaTDEEVIKLpEFKADVINDLTSIGKKDGLKgFE 626 Plasmodium falc...
Feature 1                                                   
NP_001012596 653 QVKDIIVHTEmFSIENGLLTPTLKAKRPELRKYFQSQIDELYA 695 chicken
AAW82720     631 KVKAIYVDHElFAVENDLLTVTAKLRRHKVRERYAEQIKELYA 673 Babesia bovis
EDQ74001     614 FIKAVHLDSQpFDVERDLTTPTFKLKRPQLLKYYQKEIDVMYN 656 Physcomitrella patens subsp. patens
NP_501893    646 GVYGVHLTPVaFSAENGLTTPTLKNKRNAIAQFFKAEIDGMYK 688 nematode
AAW82719     623 RCKQIYIEAEpFSIGNNMLTTTNKLRRHHAKKRYEDIIDSLYR 665 Babesia bovis
NP_503540    606 LIRNVHLTLQeFTEENGLITSTLKNRRKILEDYFAPQIAKMYK 648 nematode
Q1ZXQ4       628 IPKAIHLTPEaFSDQNNLLTPSFKLKRHEIKKYFEDEIKKLYS 670 Dictyostelium discoideum AX4
NP_182246    611 YIKAVTVETKpFDVERDLVTATLKNRRNNLLKYYQVQIDEMYR 653 thale cress
NP_175368    616 MLKAIHLEPNpFDIERDLITPTFKLKRPQLLQHYKGIVDQLYS 658 thale cress
XP_001351807 627 QIKDIHFTLEaFTIENDLMTPTGKIKRHEAKKRFKKEIDEMYE 669 Plasmodium falciparum 3D7

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