pfam15778: UNC80 (this model, PSSM-Id:406261 is obsolete and has been replaced by 464864)
Cation channel complex component UNC80
UNC80 is a family of proteins found in eukaryotes, and is typically between 193 and 224 amino acids in length. NALCN and UNC80 form a complex in mouse brain, both being tyrosine-phosphorylated; this phosphorylation can be inhibited by PP1. NALCN as the cation channel activated by substance P receptor, and the coupling from receptor to channel is facilitated by UNC80 and Src kinases rather than by a G-protein.
Jiyao W et al.(2023). "The conserved domain database in 2023.",