1SOU,1YDM,3HY6


Conserved Protein Domain Family
5-FTHF_cyc-lig

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pfam01812: 5-FTHF_cyc-lig 
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5-formyltetrahydrofolate cyclo-ligase family
5-formyltetrahydrofolate cyclo-ligase or methenyl-THF synthetase EC:6.3.3.2 catalyzes the interchange of 5-formyltetrahydrofolate (5-FTHF) to 5-10-methenyltetrahydrofolate, this requires ATP and Mg2+. 5-FTHF is used in chemotherapy where it is clinically known as Leucovorin.
Statistics
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PSSM-Id: 396398
Aligned: 18 rows
Threshold Bit Score: 155.159
Created: 26-Apr-2021
Updated: 29-Sep-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1SOU_A   3 KSELRKKVLHKRINLSeEERRRLSEKVISNLKSLPEFKKS-KKV--------ALYCPI-KGEVDLTPLFPEVLKEKELIL 72  Aquifex aeolicus
O83692   4 KQNARRIASARLRAFR-ASPTAPAYPAHSLFTAQTAYQRA-RTV--------FFYAPL-PLEIDPYALAYTAENAGKHVA 72  Treponema pallidum
O26306 134 DGGERLVEYHIWDLLVeKGVSKRP---HGRIPDFKGSFDAaKRLsrtvewerAGVVFC-SPDSAQSPVRRLVLEAGKDLI 209 Methanothermobacter t...
Q9SRE0  92 KWVIRKK---MWDLMEaRNYAMSPRPVHHRIPNFVGASAAaRKLaeldafrmAMVVKV-NPDSPQKQIRFLTLSGEKKLL 167 thale cress
1YDM_B   2 KSQLRKKTLEALSALSnEDILQKTERXYKYLFSLPEWQNA-GTI--------AVTISR-GLEIPTRPVIEQAWEEGKQVC 71  Bacillus subtilis
Q8DVY5   3 KKDYRTQVIEDLKKQDkAKKVLRDEQLLEELIQLEAYQKA-HVI--------ATYLAF-PFEFDTSLLIEQAQRDNKSIV 72  Streptococcus mutans
P40099   4 KQLLRRQIKRVINALDyDIIAAESHTISQAVRSLIASANS-RRV--------ACYMSMdKGEVTTGEIIKNLFQDGQEVF 74  Saccharomyces cerevis...
Q9XWE6   8 KSELRQFMKTLLGKISkEETQRQTEAVFEKIIESKWFQES-KRL--------SVYVST-SGEIQTDSIIQKALEMGKEVF 77  Caenorhabditis elegans
3HY6_A  10 KRSLRGELKQRLRAMSaEERLRQSRVLSQKVIAHSEYQKS-KRI--------SIFLSM-QDEIETEEIIKDIFQRGKICF 79  human
P80405  10 KRSLRAELKQRLRAISaEERLRCQRLLTQKVIAHRQYQKS-QRI--------SIFLSM-PDEIETEEIIKDIFQQGKVCF 79  rabbit
1SOU_A  73 PKVEGNEI--------------------------SLYRVHSPACLGVGAFG--------IMEPVEGERVNPE-----DVD 113 Aquifex aeolicus
O83692  73 LPRVSGNDlhfhavtya---------cttrpsvsCFTTLCPRTRGIREPDAhsprlyppHPSPNTPAQRTLA-----LPL 138 Treponema pallidum
O26306 210 MPTPKIKDgyl--------------------ligGDVPDAEAASTIGGAYM--------YGSPIREFP---------QVD 252 Methanothermobacter t...
Q9SRE0 168 TPQPRLRTgff--------------------svlESDLLKPETIMEACTSV-----------GVAKYGRAIGldekiKVD 216 thale cress
1YDM_B  72 IPKCHPDTkk-----------------------xQFRTYQTDDQLETVYAG--------LLEPVIEKTKEVNp---sQID 117 Bacillus subtilis
Q8DVY5  73 VPKTYPQGk-------------------------MIFVVYDEADLQITKFG--------LKEPRSEEALEKS-----AID 114 Streptococcus mutans
P40099  75 LPRCTHTSeskhfklredhhphlifhrmsslkmvR-------DLKPQGPYQ--------LKEPEPHIEESD------ILD 133 Saccharomyces cerevis...
Q9XWE6  78 IPQFTKGStam--------------------dmvRVPDQTAFDNLPSTLWG--------IRQPEPKWKWQSYhe-tgPLD 128 Caenorhabditis elegans
3HY6_A  80 IPRYRFQSnhm--------------------dmvRIESPEEISLLPKTSWN--------IPQPGEGDVREEAls-tgGLD 130 human
P80405  80 IPRYRLQSnhm--------------------dmvKLASADEISSLPKTSWN--------IHQPSESDTREEAla-tgGLD 130 rabbit
1SOU_A 114 FIAVPGVAFD-LEGYRLGFGKGYYDRLLKRVKG-------LKVGVAYSFQVFE-RLPRDA---WDIPVDVLVTE 175 Aquifex aeolicus
O83692 139 LIVVPALAFS-TNGARLGRGGGHYDRFLARIAAtipagsyYTLGLCFDCQIMA-VIPQEA---HDQSVHAVLTE 207 Treponema pallidum
O26306 253 LVVEGSVAVD-LQGNRLGKGGGYGDREISELRGqgaidedTPLATTVDELQIIrRVPVEE---HDEMINMIVTP 322 Methanothermobacter thermau...
Q9SRE0 217 LIVIGSVAVNpQTGARLGKGEGFAELEYGMLRYmgaiddsTPVVTTVHDCQLVdDIPLEKlaiHDVPVDIICTP 290 thale cress
1YDM_B 118 LXIVPGVCFD-VNGFRVGFGGGYYDRYLSEYEG-------KTVSLLLECQLFA-HVPRLP---HDIPVHKLITE 179 Bacillus subtilis
Q8DVY5 115 LIHVPGLAFN-NEGYRIGFGAGYYDQYLADFQG-------DTVSTIYSFQKFT--FEPSF---FDIPVKEVLVs 175 Streptococcus mutans
P40099 134 VVLVPGVAFDiKTGARMGHGAGYYDDFFQRYKIlhegqkpLLVGLCLMEQVAS-PIPLEK---HDYSMDCIVCG 203 Saccharomyces cerevisiae S288C
Q9XWE6 129 LILAPGVAFS-PYGLRCGHGKGYYDRFFSTHHKhfpenspKKIGLALREQIIG-TIPISE---TDVELDEVIYE 197 Caenorhabditis elegans
3HY6_A 131 LIFMPGLGFD-KHGNRLGRGKGYYDAYLKRCLQhqe-vkpYTLALAFKEQICL-QVPVNE---NDMKVDEVLYE 198 human
P80405 131 LIFMPGLGFD-RNGNRLGRGRGYYDTYLQRCLQqqg-akpYTIALAFREQICP-QVPVDD---TDVSVDEVLYV 198 rabbit
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