1A2K,1OUN,1GY7,1JN5,1JKG


Conserved Protein Domain Family
NTF2
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cd00780: NTF2 
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Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many soluble factors that includes GDP-binding protein Ran (RanGDP). RanGDP is required for both import and export of proteins and poly(A) RNA. RanGDP also has been implicated in cell cycle control, specifically in mitotic spindle assembly. In interphase cells, RanGDP is predominately nuclear and thought to be GTP bound, but it is also present in the cytoplasm, probably in the GDP-bound state. NTF2 mediates the nuclear import of RanGDP. NTF2 binds to both RanGDP and FxFG repeat-containing nucleoporins.
Links
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Statistics
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PSSM-Id: 238403
Aligned: 46 rows
Threshold Bit Score: 77.7081
Created: 7-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 13 residues -Click on image for an interactive view with Cn3D
Feature 1:RanGDP-NTF2 interaction
Evidence:
  • Structure:1A2K_A:structure of NTF2-RanGDP complex
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                           ##                                        
1A2K_A      6 IWEQIGSSFIQHYYQLfd---nDRTQLGAIYIdASCLTWEg---------------------------------QQFQGK 49  Norway rat
1JKG_B     13 NLKSLVLHFLQQYYAIyd--sgDRQGLLDAYHdGACCSLSipfipqnparsslaeyfkdsrnvkklkdptlrfrLLKHTR 90  human
NP_501842  96 AAEQVGGAFCHQFYITvs---eNRKAITKFYGhESKFYLDd---------------------------------QVVTGS 139 Caenorhabditis ele...
CAB75912  162 PSVPESAGFVKVYYELp-----MREELGLMYVnESIMSRPtsts--------------------------grtmVEMPGL 210 thale cress
P53741      4 TVQDICFAFLQNYYERmr---tDPSKLAYFYAsTAELTHTnyqskstn------------------ekddvlptVKVTGR 62  baker's yeast
EAA37502    2 DPNSLASSFVQHYYSNfcn-qaTRANVLSLYSpTAQMIFNg---------------------------------THCRGI 47  Giardia lamblia AT...
XP_307993 364 SGADLVRQFLEQYFTIyd--sdNRQPLLEAYHeHAMFSLTvnttyqsnqqklgayis-gsrnikhktdldsrcrFLKQGR 440 Anopheles gambiae ...
CAC14534   11 TAFTVASTFLAYYYSEfvk-lnELARMSDLYDeRSYMTLVdfrd---------------------------evpVVAHGR 62  Leishmania major
BAA28829  362 RLKDLADMLTIHYYSLfdgfddLWHHAKSLYTeTSVFSFSg---------------------------------KHNTGS 408 thale cress
Q9U1H9    371 AGAEVVRQFLDQYFRIfd--sgNRQALLDAYHeKAMLSISmpsasqagrlnsfwkf--nrnlrrllngeenrtrNLKYGR 446 fruit fly

Feature 1              #            #                          # # ##            #  #         
1A2K_A     50 aAIVEKLSSLpf--------qkIQHSI--TAQDHQPtpd--scIISMVVGQLKADe-----------DPIMGFHQMFLLK 106 Norway rat
1JKG_B     91 lNVVAFLNELp----------kTQHDVnsFVVDISAqts--tlLCFSVNGVFKEVdgk-------srDSLRAFTRTFIAV 151 human
NP_501842 140 qEIVKLYNHLp----------eTTHFKi-QSIKGYPtph-kqgVIINVIGTVNLRpf---------lQSFLLGQQGQKKY 198 Caenorhabditis ele...
CAB75912  211 dAINKRVSNEhk--------raSNFIL--NSVDYQIsrsfkdrMFIMVCGFVTLDd-----------KTERKFLQFFYVT 269 thale cress
P53741     63 eNINKFFSRNdak------vrsLKLKL--DTIDFQYtghlhksILIMATGEMFWTg-----------TPVYKFCQTFILL 123 baker's yeast
EAA37502   48 eAIQQQLERMs----------fKTVNI--PNPTISAmdl-ggrYLVKVSGLLSIDd----------sNQPIGFAHVFVLG 104 Giardia lamblia AT...
XP_307993 441 lQVVSHLSSLp----------pTKHDLtsFAVDLTLftp--hmLQLTVTGVFKERkgs------gnmEQIRSFQRTLVIV 502 Anopheles gambiae ...
CAC14534   63 nAVANLLAKLdst------lgqRKVEI--ITVDTVAlph--ncVQVICQGVMYLR------------EYRRVFLHVFMLE 120 Leishmania major
BAA28829  409 tEIFSALSDIrntltgdlpsekLVHVV--EKLHCKPcgs--ggVIIRAVGSFIVGnqf------licGDGVQAEGLPSFK 478 thale cress
Q9U1H9    447 lACVSTLDEWp----------kTQHDRrtFTVDLTIynt--smMVFTVTGLFKELndetnnpasmelYDVRHFARTYVVV 514 fruit fly

Feature 1                      # # #
1A2K_A    107 Nin-----dAWVCTNDMFRLAL 123 Norway rat
1JKG_B    152 Pas----nsGLCIVNDELFVRN 169 human
NP_501842 199 Yve-----sDAFQYIDKFFVAN 215 Caenorhabditis elegans
CAB75912  270 Rch----ngSYVIYNDILRYVD 287 thale cress
P53741    124 Pssn---gsTFDITNDIIRFIS 142 baker's yeast
EAA37502  105 Snn-----gSFYIEGEIFSFAI 121 Giardia lamblia ATCC 50803
XP_307993 503 Psn-----gGFCIRNEMMHVNT 519 Anopheles gambiae str. PEST
CAC14534  121 Ptay--rtkTYHIASDYLRFVD 140 Leishmania major
BAA28829  479 DlgfdvasrRVGRFQEQFVVES 500 thale cress
Q9U1H9    515 Pqn-----nGFCIRNETIFITN 531 fruit fly

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