2GOW,1WGH


Conserved Protein Domain Family
Ubl_UBL3

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cd17048: Ubl_UBL3 
ubiquitin-like (Ubl) domain found in ubiquitin-like protein 3 (UBL3) and similar proteins
UBL3, also termed membrane-anchored ubiquitin-fold protein (MUB), or protein HCG-1, belongs to a newly described MUB protein family with structural homology with ubiquitin. MUB proteins have a beta-grasp ubiquitin-like (Ubl) domain with longer N- and C-termini and extended loops. The Ubl domain contains a C-terminal CAAX-box, a canonical motif for protein prenylation, which is modified through protein lipidation with a hydrophobic membrane anchor. The lipidation and membrane localization inhibit attachment of MUBs to target proteins.
Statistics
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PSSM-Id: 340568
Aligned: 19 rows
Threshold Bit Score: 159.466
Created: 9-Jul-2015
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
key conserved
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1: key conserved lysines, 3 residue positions
Conserved feature residue pattern:[KR] [KR] [KR]Click to see conserved feature residue pattern help
Evidence:
  • Comment:3 (K11, K48/R,K63K, Ub numbering) of the 7 lysines involved in chain linkage in ubiquitin (K6, K11, K27, K29, K33, K48, or K63, Ub numbering) are conserved in this family, K27 a lysine highly conserved in the Ubl_ubiquitin_like family is not conserved in this subfamily, for most in this subfamily the residue corresponding to K6 is a conserved Ile, for K33 is a conserved Asn; may have roles other than chain linkage

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                   #                                            #                #      
2GOW_A        18 INLRLILVs-GKTKEFLFSPnDSASDIAKHVYDNwpmdweeeqvsSPNILRLIYQGRFLHGNVTLGAlkLPFGKTTVMHL 96  human
ELT95730      14 INLRLILVs-GKTREFLFAPtDSAADITQHVYDNwpedwhdeqlpATNILRLIYQGRFLHGNVTLGAlqLPVGKTTVMHL 92  Capitella teleta
EFX72459      12 VNLRLILVs-GKTKEFLFSPeDSASEIAQFVFDNwpeewneegvsRAEILRLIYQGRFLHGNVTLGAlgLPPGRTSVMHL 90  common water flea
AAD02321     236 INLRLILVs-GKTKEFIFSPsDSAGDIAQTVFDNwpedwthetvsKAEILRLIYQGRFLHCNVTLGAlgLPLGKTTVMHL 314 fruit fly
XP_002112936   2 INLKLILVt-GKTHEFLFLPeTAAGDITQHVFNNwppewedeavdNSSKLRLIYQGRFLQNESILSSmrLPAGKTTVMHL 80  Trichoplax adha...
XP_001626774  16 ICLRLILVs-GKTHEFVFSPsDTAYYITQQVFEHwpedwkeetvsSHNILKLIYQGRFLHGNVTLGAlhLPLGKRTVMHL 94  starlet sea ane...
XP_001177227  10 VTLRIIHPmnGNNKEFNFVPeDTASDVSQYVFDNwpedwennrvrSAHILRLIYQGRFIHGNVSLGAlqLPLGKTTAMHI 89  purple sea urchin
NP_001021222  14 VVLRLILVs-GKTHEFEFHPlTSAHDVTQMVFDQwpdewyedkvqSAQMLKLIYHGRFLHGSVTLHAlqLMPGKTTVMHL 92  Caenorhabditis ...
XP_013091960  11 INLKLILVs-GKTHEFLFSPsDSAADIAEHVYTHwpedwadeqmpATNILRLIYQGRFLHGNVTLTAlqLPTGKTSVMHL 89  Biomphalaria gl...
XP_013387431   8 ISLKLILVs-GKTNEFLFTPnSSAAEITQYVYDNwpqgwadeqlpPTNILRLIYQGRFLHGNVTLGAlqLPVGKMTVMHL 86  Lingula anatina
Feature 1           
2GOW_A        97 VAR 99  human
ELT95730      93 VAR 95  Capitella teleta
EFX72459      91 VPR 93  common water flea
AAD02321     315 VPR 317 fruit fly
XP_002112936  81 VAR 83  Trichoplax adhaerens
XP_001626774  95 VAR 97  starlet sea anemone
XP_001177227  90 MAR 92  purple sea urchin
NP_001021222  93 VTR 95  Caenorhabditis elegans
XP_013091960  90 VAR 92  Biomphalaria glabrata
XP_013387431  87 VAR 89  Lingula anatina

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