GEO DataSets

(Submitter supplied) Medulloblastomas are heterogeneous tumors that collectively represent the most common malignant brain tumor in children. To understand the molecular characteristics underlying their heterogeneity and to identify whether such characteristics represent risk factors for patients with this disease, we performed an integrated genomic analysis of a large series of primary tumors. Identified are six molecular subgroups of medulloblastoma, each with a unique combination of numerical and structural chromosomal aberrations that globally influence mRNA and miRNA expression. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL3921

214 Samples

Download data: CEL, GCT, XLS, XLSX

(Submitter supplied) Despite significant progress in the molecular understanding of medulloblastoma, stratification of risk in patients remains a challenge. Focus has shifted from clinical parameters to molecular markers, such as expression of specific genes and selected genomic abnormalities, to improve accuracy of treatment outcome prediction. Here, we show how integration of high-level clinical and genomic features or risk factors, including disease subtype, can yield more comprehensive, accurate, and biologically interpretable prediction models for relapse versus no-relapse classification. more...

Organism:

Homo sapiens

Type:

Expression profiling by array; Third-party reanalysis

Platform:

GPL3921

111 Samples

Download data: CEL, GCT, TXT

(Submitter supplied) There are no effective treatments or clinical response markers for systemic sclerosis (SSc). We sought to assess the potential of novel imaging biomarkers and gene expression profiling approaches in a clinical trial of the tyrosine kinase inhibitor dasatinib in SSc patients with interstitial lung disease (SSc-ILD).

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL3921

45 Samples

Download data: CEL

(Submitter supplied) The goal of this study is to define the molecular signatures of prednisolone and BMS-791826 in normal healthy volunteers. IM125001 (NCT03198013) is a phase I, placebo-controlled, double-blind, ascending single and multiple oral dose study to evaluate the safety, pharmacokinetics and pharmacodynamics of bms-791826 and to assess its marker specific pharmacodynamics in relation to prednisolone in healthy males, sponsored by Bristol-Myers Squibb.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL3921

39 Samples

Download data: CEL

(Submitter supplied) The goal of this study is to define the molecular signatures of prednisolone in vivo. IM124001 (NCT03196557) is an experimental medicine study to assess the pharmacodynamics following administration of multiple doses of prednisolone to healthy male subjects, sponsored by Bristol-Myers Squibb.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL3921

154 Samples

Download data: CEL

(Submitter supplied) The goal of this study is to validate genes that are regulated by glucocorticoids or partial GR agonists in whole blood in vitro.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL3921

15 Samples

Download data: CEL

(Submitter supplied) The goal of these studies is to identify genes that are regulated by glucocorticoids in human peripheral blood mononuclear cells in vitro.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL3921

58 Samples

Download data: CEL

(Submitter supplied) CD8 T cells play an importart role in adaptive immunity to intracellular pathogens. Naïve CD8 T cells , that have not encountered antigen previously can be identified by virtue of their distinct phenotype. Upon antigenic encounter, they proliferate rapidly and undergo massive reprograming to differentiate to cytotoxic T lymphocytes. The yellow fever live virus vaccine (YF-17D) provides a model primary acute viral infection that can be used to follow this response.Here we characterize the resting, non-activated naive CD8 T cells in nine healthy adults and YF-specific CD8 T cells elicited in response to YF-17D vaccination from the same donors during the effector (2 weeks after vaccination) and memory (5-8 months later) stages.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL570 GPL3921

34 Samples

Download data: CEL

(Submitter supplied) TCGA Analysis of RNA Expression for Glioblastoma Multiforme Using Affymetrix HT_HG-U133A

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL3921

701 Samples

Download data: CEL, CHP, TXT

(Submitter supplied) TCGA Analysis of RNA Expression for Ovarian Serous Cystadenocarcinoma Using Affymetrix HT_HG-U133A

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL3921

527 Samples

Download data: CEL, TXT

(Submitter supplied) TCGA Analysis of RNA Expression for Glioblastoma Multiforme Using Affymetrix HT_HG-U133A

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL3921

228 Samples

Download data: CEL, CHP

(Submitter supplied) In our efforts to evaluate the function of the IL-8 receptor CXCR2 in Acute Lymphoblastic Leukemia (ALL) cells, we made use of SB225002 (N-(2-hydroxy-4-nitrophenyl)-N’-(2-bromophenyl)urea), a drug initially described as a CXCR2 antagonist. Although the CXCR2 receptor was found to be non-functional in ALL, B- and T-ALL cell lines were sensitive to SB225002. We used microarray analysis to identify a transcriptional profile of genes that mediate SB225002's effects in acute lymphoblastic leukemia cells.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL3921 GPL9197

16 Samples

Download data: CEL, CHP

(Submitter supplied) The microarray gene expression pattern was studied using 798 different cancer cell lines. The cancer cell lines are obtained from different centers. Annotation information were provided in the supplementary file.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL3921

798 Samples

Download data: CEL, EXP, TXT

(Submitter supplied) TCGA Analysis of RNA Expression for Glioblastoma Multiforme Using Affymetrix HT_HG-U133A

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL3921

228 Samples

Download data: CEL, TXT

(Submitter supplied) TCGA Analysis of RNA Expression for Non Small Cell Lung Cancer, Squamous Cell Carcinoma Using Affymetrix HT_HG-U133A

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL3921

135 Samples

Download data: CEL, TXT

(Submitter supplied) TCGA Analysis of RNA Expression for Glioblastoma Multiforme Using Affymetrix HT_HG-U133A

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL3921

527 Samples

Download data: CEL, CHP

(Submitter supplied) While early stages of clear cell renal cell carcinoma (ccRCC) are curable, survival outcome for metastatic ccRCC remains poor. The purpose of the current study was to apply a new individualized bioinformatics analysis (IBA) strategy to these transcriptome data in conjunction with Gene Set Enrichment Analysis of the Connectivity Map (C-MAP) database to identify and reposition FDA-approved drugs for anti-cancer therapy. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL3921 GPL9197

8 Samples

Download data: CEL, CHP

(Submitter supplied) The HMT3522 progression series of breast cells has been used to discover the roles of tissue architecture, microenvironment and signaling molecules in nonmalignant and malignant breast cell growth and behaviors, including the potential of various factors to cause phenotypic reversion of malignant cells to nonmalignant states. Despite many efforts to delineate key signaling pathways governing the malignant as well as the phenotypic reversion behaviors of T4 cells, much remains to be elucidated about the regulatory mechanisms underlying these cell states at the systems level. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL4685 GPL3921

15 Samples

Download data: CEL

(Submitter supplied) Gene expression profiling of 111 colon tissues from tumors and adjacent noncancerous tissues. Genotypes for the rs5995355 in NCF4 are included to identify genes whose expression are associated with this genotype.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL3921

111 Samples

Download data: CEL

(Submitter supplied) Cooperative dependencies between mutant oncoproteins and wild-type proteins are critical in cancer pathogenesis and therapy resistance. Although spleen tyrosine kinase (SYK) has been implicated in hematologic malignancies, it is rarely mutated. We used kinase activity profiling to identify collaborators of SYK in acute myeloid leukemia (AML) and determined that FMS-like tyrosine kinase 3 (FLT3) is transactivated by SYK via direct binding. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL3921

21 Samples

Download data: CEL