GEO DataSets

(Submitter supplied) The GUSTO clinical trial (Gene expression subtypes of Urothelial carcinoma: Stratified Treatment and Oncological outcomes) uses molecular subtypes to guide neoadjuvant therapies in participants with muscle-invasive bladder cancer (MIBC). Before commencing the GUSTO trial, we needed to determine the reliability of a commercial subtyping platform (Decipher Bladder; Veracyte) when performed in an external trial laboratory as this has not been done previously. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL5175

54 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array; Non-coding RNA profiling by high throughput sequencing

Platforms:

GPL15456 GPL5175

120 Samples

Download data: CEL, CHP, TXT

(Submitter supplied) Transcriptomic analysis of lymphoblastoid cell lines from ALS patients with varying disease duration Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, associated with the degeneration of both upper and lower motor neurons of the motor cortex, brainstem and spinal cord. Death in most patients results from respiratory failure within 3-4 years from symptom onset. However, due to disease heterogeneity some individuals survive only months from symptom onset while others live for several years. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL5175

42 Samples

Download data: CEL, CHP

(Submitter supplied) Gene expression study of the VANDAAM Phase II clinical trial

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL5175

226 Samples

Download data: CEL

(Submitter supplied) Breastfeeding protects against mucosal infections in infants. The underlying mechanisms through which immunity develops in human milk following maternal infection with mucosal pathogens are not well understood. We simulate mucosal influenza infection through live attenuated influenza vaccination (LAIV) and compared milk and blood immune responses to inactivated influenza vaccination (IIV). Transcriptomic analysis was performed on RNA extracted from human milk and whole blood. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL5175

361 Samples

Download data: CEL

(Submitter supplied) Radiation-induced late effects remain a common cause of morbidity amongst cancer survivors. The purpose of this study was to investigate the molecular basis underlying the radiotherapy-induced late skin toxicity in breast cancer patients who were previously assessed for radiation-induced lymphocyte apoptosis (RILA).

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL5175

40 Samples

Download data

(Submitter supplied) Gene expression study of the ECOG 3805 randomized controlled trial

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL5175

160 Samples

Download data: CEL

(Submitter supplied) Despite the discovery of many genetic risk factors, the cause of the motor neuron death that drives terminal pathology in Amyotrophic Lateral Sclerosis (ALS) remains unknown. We report that the skeletal muscle of ALS patients secretes exosomal vesicles that are specifically toxic to motor neurons. This could not be attributed to a trivial down-stream consequence of muscle denervation. In a study of muscle biopsies and biopsy-derived denervation-naïve differentiated muscle stem cells (myotubes) from 67 human subjects, including healthy and disease controls, ALS myotubes had a consistent signature of disrupted exosome biogenesis and RNA-processing, and their exosomes induced shortened, less branched, neurites, greater death, and disrupted localization of RNA and RNA-processing proteins in motor neurons. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL5175

12 Samples

Download data: CEL

(Submitter supplied) Control samples used to performed gene expression comparison with breast cancer tissues. mRNA samples from normal breast tissue were amplified, labeled, and hybridized to the Affymetrix GeneChip Human Exon 1.0 ST array. After normalization and analysis of the microarray data using Partek® software (http://www.partek.com).

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL5175

4 Samples

Download data: CEL, CHP

(Submitter supplied) The Hypoxia-Inducible Factors induce the expression of the histone demethylases JMJD1A (KDM3A) and JMJD2B (KDM4B), linking the hypoxic tumor microenvironment to epigenetic mechanisms that may foster tumor progression. Using transcript profiling, we have identified genes that are regulated in RCC4 with siRNA-mediated knockdown of JMJD1A and JMJD2B. This dataset includes expression data obtained from renal cell Carcinoma being loss or mutation of the von Hippel-Lindau (VHL) tumor suppressor gene combination with siRNA-mediated knockdown of histone demethylases JMJD1A and JMJD2B.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL5175

9 Samples

Download data: CEL

(Submitter supplied) The Hypoxia-Inducible Factors induce the expression of the histone demethylases JMJD1A (KDM3A) and JMJD2B (KDM4B), linking the hypoxic tumor microenvironment to epigenetic mechanisms that may foster tumor progression. This dataset includes expression data obtained from exposing colon carcinoma cells to hypoxia in combination with siRNA-mediated knockdown of the hypoxia-inducible histone demethylases JMJD1A and JMJD2B.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL5175

18 Samples

Download data: CEL

(Submitter supplied) Chronic lymphocytic leukemia shows a variable clinical course which is associated with distinct alterations such as chromosomal aberrations, gene mutations or IGHV mutation status. Refining biologic categories may help to improve clinical management with available and future treatment, lymphoma/leukemia celllines and non-tumour cells of the microenvironment can be used for models to better categorize biologic CLL entities. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL5175

43 Samples

Download data: CEL

(Submitter supplied) Chronic lymphocytic leukemia shows a variable clinical course which is associated with distinct alterations such as chromosomal aberrations, gene mutations or IGHV mutation status. Refining biologic categories may help to improve clinical management with available and future treatment approaches. We used Affymetrix Exon 1.0 ST microarrays to investigate differences in CLL biology.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL5175

726 Samples

Download data: CEL

(Submitter supplied) Cancer associated fibroblasts (CAFs) are the major cellular component of the tumor microenvironment and they have been shown to stimulate tumor growth, epithelial-to-mesenchymal transition (EMT), invasion and radio-resistance. We used microarrays to investigate the influence of CAFs on the gene expression profile of HNSCC cells in 2D co-cultures

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL5175

10 Samples

Download data: CEL

(Submitter supplied) Gene expression characteristics of primary prostate cancer tumors from African-Americans are substantially different as compared to European-American men

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL5175

1152 Samples

Download data: CEL, CSV

(Submitter supplied) Skeletal muscle aging is characterized by a progressive decline in muscle mass and function, which is referred to as sarcopenia. Aging is also a primary risk factor for metabolic syndrome (SX), which is a cluster of risk factors for cardiovascular diseases and type 2 diabetes. However, the molecular mechanisms implicated in sarcopenia and changes in muscle proteome associated with SX in elderly men remain unclear. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL5175

30 Samples

Download data: CEL

(Submitter supplied) Inflammatory Breast Cancer (IBC) is the most aggressive form of breast carcinoma characterized by the rapid onset of inflammatory signs. The molecular fingerprint for this rare, severe and unique clinical entity is still not elucidated. The goal of the present work was to detect both gene expression levels and alternate RNA splice variants specific to IBC. Experimental Design: In order to identify differentially expressed genes and splicing events, we performed splice-sensitive array profiling using Affymetrix Exon Array and quantitative RT-PCR analyses in a large series of 177 IBC compared to 183 non-IBC. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL5175 GPL5188

122 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by array

Platforms:

GPL5175 GPL9115 GPL11154

26 Samples

Download data: BED, CEL, CHP, TDF, WIG

(Submitter supplied) Microarray-based expression analysis in HT and SUDHL6 cell lines.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL5175

2 Samples

Download data: CEL, CHP

(Submitter supplied) The ACP02 cell line was stablished from a primary diffuse adenocarcinoma (T3N2M0) and AGP01 cell was established from ascitic fluid cells from intestinal gastric adenocarcinoma (T3N2M1). mRNA samples from cell lines were amplified, labeled, and hybridized to the Affymetrix GeneChip Human Exon 1.0 ST array. The chip array data analysis was performed with Partek® software (http://www.partek.com).

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL5175

2 Samples

Download data: CEL, CHP