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Items: 1 to 20 of 2426

1.

Gene expression in gastrocnemius muscle in response to calorie restriction in wildtype and Sirt3 knockout mice

(Submitter supplied) The effect of calorie restriction from two to 12 months of age was evaluated in gastrocnemius muscle in both wildtype mice as well as Sirt3 knockout mice The dietary intervention was initiated at 2 months of age and continued until 12 months of age
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
15 Samples
Download data: CEL, CHP
Series
Accession:
GSE64229
ID:
200064229
2.

Expression data from mouse splenic B cells

(Submitter supplied) We used microarrays to detail the impact on B cell gene expression program by Zeb2 enhancer deletion
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
6 Samples
Download data: CEL
Series
Accession:
GSE167458
ID:
200167458
3.

Comparative gene expression in adult SVZ-neurospheres differentiated under standard conditions and upon manipulations of Pax6 (OE) and/or Pbx1 (KD/OE)

(Submitter supplied) We used microarrays to detail the global programme of gene expression underlying neuronal differentiation of SVZ-neurospheres when manipulating Pax6 expression in the presence or absence of Pbx1
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
8 Samples
Download data: CEL
Series
Accession:
GSE172449
ID:
200172449
4.

Expression data of in vitro co-cultures comparing PKCa-KR- vs MIEV-transduced B lineage cells

(Submitter supplied) We performed Affymetrix microarray gene chip analysis on PKCa-KR- vs MIEV retrovirally transduced mouse B lineage cells that had been co-cultured for 17-23 days (late co-culture) to establish B cell transformation. Expression analysis was performed between PKCa-KR and MIEV samples.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
10 Samples
Download data: CEL
Series
Accession:
GSE185075
ID:
200185075
5.

Regulation of gene expression in splenic cDC1 isolated from WT vs XCR1-/- miceNK cells orchestrate cDC1 migration to potentiate antiviral protective CD8+ T cell responses

(Submitter supplied) The expression of the XCR1 chemokine receptor univocally identifies all type 1 conventional dendritic cells (cDC1) throughout the body. The gene encoding its ligand, XCL1, is expressed constitutively by innate lymphoid cells such as natural killer (NK) cells. The evolutionary conservation of XCR1, XCL1 in vertebrates suggests that they play a critical, yet uncharacterized, role in immune responses. Here we showed using mouse cytomegalovirus (MCMV) infection, that the XCL1/XCR1 axis promoted the intra-splenic repositioning of cDC1 towards IFN--producing NK cells forming superclusters around infected cells. There, cDC1 and NK cells engaged into physical interactions enhancing their respective production of IL-12 and IFN-. This feed-forward mechanism also led to NK cell production of GM-CSF, which upregulated CCR7 on cDC1, instructing them to migrate into the T cell area for the priming of CD8+ T cells. In conclusion, we identified a novel mechanism through which NK cells boost the relay between innate and adaptive immunities by regulating the spatiotemporal functions of cDC1.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
8 Samples
Download data: CEL
Series
Accession:
GSE142402
ID:
200142402
6.

Transcriptional profiling of mouse liver of PPARgamma null mice

(Submitter supplied) We highlight sex dimorphism of NAFLD in a lipodystrophic mouse model obtained via total body deletion of PPARγ. The hepatic sex dimorphism is characterized by a more important hepatosteatosis in females compared to males, and is PPARγ- and sex-hormone-dependent. To characterize the molecular mechanisms underlying this phenotype microarray analysis of gene expression was performed in the liver of 7 and 20 week old mice, before and after the onset of the the hepatic sex-dimorphism.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
23 Samples
Download data: CEL, TXT
Series
Accession:
GSE176226
ID:
200176226
7.

Oligodendrocyte degeneration triggers the formation of inflammatory brain lesions

(Submitter supplied) Here, we investigated whether cuprizone-induced oligodendrocyte apoptosis is sufficient to trigger peripheral immune cell recruitment into the forebrain. We show that early cuprizone-induced white matter lesions display a striking similarity to early MS lesions, i.e., oligodendrocyte degeneration, microglia activation and absence of lymphocytes. Such early cuprizone lesions are sufficient to trigger peripheral immune cell recruitment. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
8 Samples
Download data: CEL
Series
Accession:
GSE119672
ID:
200119672
8.

Expression data from dissected postnatal 0 (P0) Meg2 (protein-tyrosine phosphatase non-receptor type 9, Ptpn9) knockout and wild-type mouse retinae.

(Submitter supplied) In our dataset, we included the expression data obtained from P0 dissected Meg2 knockout and wild-type mouse retinae. Most interestingly, we observed a dysregulation of several candidate genes known to be differentially expressed in response to retinal/glaucomatous neurodegeneration, which includes genes related to apoptosis, excitotoxicity, immune activation, neurotrophic signaling, oxidative stress and loss of synaptic integrity. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
6 Samples
Download data: CEL
Series
Accession:
GSE119246
ID:
200119246
9.

LMO3 reprogramms viseral adipocyte metabolism during obesity

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus; Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL19057 GPL6246 GPL6244
16 Samples
Download data: CEL, TXT
Series
Accession:
GSE139163
ID:
200139163
10.

LMO3 reprogramms viseral adipocyte metabolism during obesity [Mouse]

(Submitter supplied) Aims/Hypothesis. The aim of this study was to determine the potential involvement of LMO3-dependent pathways in the modulation of key functions of mature adipocytes during obesity. Methods. Based on a recently engineered hybrid rAAV serotype Rec2 shown to efficiently transduce both brown adipose tissue (BAT) and white adipose tissue (WAT), we delivered YFP  or Lmo3 to epididymal WAT (eWAT) of C57Bl6/J mice on a high fat diet (HFD). more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
6 Samples
Download data: CEL
Series
Accession:
GSE139162
ID:
200139162
11.

B cells acquire a unique and differential transcriptomic profile during pregnancy in mice

(Submitter supplied) Pregnancy significantly alters B cells development and function. B cell activation is initiated by antigens specific binding to the BCR, leading to an intricate signaling pathway responsible for B cell survival, proliferation, antigen processing/presentation and antibody production. We performed a genome-wide transcriptome profiling in splenic B cells from pregnant (P) and non-pregnant (NP) mice. We identified 1136 genes with differential expression in B cells from P mice (625 up- and 511 down-regulated) compared to NP animals. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
8 Samples
Download data: CEL
Series
Accession:
GSE174290
ID:
200174290
12.

Diet-induced alteration of intestinal stem cell identity and lineage allocation underlies obesity and pre-diabetes in mice

(Submitter supplied) Excess nutrient uptake and altered hormone secretion in the gut contribute to a systemic energy imbalance causing obesity and increased risk for type 2 diabetes (T2D) and colorectal cancer. This functional maladaptation is thought to emerge at the level of the intestinal stem cells (ISCs). But, how an obesogenic diet affects ISC identity and fate decisions is not well understood. Here, we study the intestinal responses to an obesogenic diet in mice by combining single-cell profiling of more than 27,000 small intestinal crypt cells with genetic lineage labelling and tracing of ISC fate decisions and in situ metabolomics. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
15 Samples
Download data: CEL
Series
Accession:
GSE148227
ID:
200148227
13.

48hr 2a3 vs YTS177 CD4+ PLN T cell Microarray

(Submitter supplied) BDC2.5 mice treated with 1mg isotype control (2a3) or anti-CD4 (YTS177) antbodies for 48hrs. PLN CD4+ T cells sorter for microarray analysis.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
2 Samples
Download data: CEL, CHP
Series
Accession:
GSE179650
ID:
200179650
14.

Transient JAK/STAT pathway inhibition prevents natural occurring B-ALL development in genetically predisposed Pax5+/- mice

(Submitter supplied) We used microarrays to investigate gene expression changes in bone marrow B220+ cells from Pax5+/- and wild-type mice after ruxolitinib treatment during 2 weeks. Preventing development of B cell acute lymphoblastic leukemia (B-ALL), a disease with devastating effects in children, is a longstanding and unsolved challenge in medicine. In humans and mice, germline alterations in the Pax5 gene can lead to B-ALL. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
18 Samples
Download data: CEL
Series
Accession:
GSE179182
ID:
200179182
15.

Expression data from NR2F2(COUP-TFII) depleted mouse MA-10 Leydig cells

(Submitter supplied) In males, Leydig cells are the main producers of testosterone and insulin-like 3, hormones which are both essential for sex differentiation and reproductive functions. Nuclear receptor chicken ovalbumin upstream promoter-transcription factors II (COUP-TFII) is expressed in the cells committed to give rise to the fully functional steroidogenic adult Leydig cells and has a major role in their function and differentiation. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
6 Samples
Download data: CEL, XLSX
Series
Accession:
GSE163283
ID:
200163283
16.

Effect of electroacupuncture on the skeletal muscle atrophy induced by hindlimb suspension in mice

(Submitter supplied) The effect of electroacupuncture on the transcriptional profile of the skeletal muscle atrophy induced by hindlimb suspension were examined. We used microarrays to detail the global programme of gene expression underlying cellularisation and identified distinct classes of up-regulated and down-regulated genes during this process.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
6 Samples
Download data: CEL, CHP
Series
Accession:
GSE38874
ID:
200038874
17.

Epithelial cell plasticity drives endoderm formation during gastrulation

(Submitter supplied) It is generally accepted that epiblast cells ingress into the primitive streak by epithelial-to-mesenchymal transition (EMT) to give rise to the mesoderm; however, it is less clear how the endoderm acquires an epithelial fate. Here, we used embryonic stem cell and mouse embryo knock‐in reporter systems to combine time-resolved lineage labelling with high-resolution single-cell transcriptomics. This allowed us to resolve the morphogenetic programs that segregate the mesoderm from the endoderm germ layer. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
16 Samples
Download data: CEL
Series
Accession:
GSE148226
ID:
200148226
18.

IRF8-dependent control of pDC terminal differentiation and MYC repression

(Submitter supplied) A switch from MYC expression in bone marrow progenitors to MYCL expression in terminal dendrtitic cell (DC) subsets occurs during DC development. The present study identifies the precise stage during DC development when this switch occurs, and identifies a role for IRF8 in control of this switch. IRF8 is found to be required for both MYC repression and MYCL induction during DC specification in vivo.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
6 Samples
Download data: CEL
Series
Accession:
GSE176508
ID:
200176508
19.

Dynamic of broad H3K4me3 domains uncover an epigenetic switch between cell identity and cancer-related genes

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens; Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by array
Platforms:
GPL18573 GPL6246 GPL14602
23 Samples
Download data: BED, BW, CEL
Series
Accession:
GSE164228
ID:
200164228
20.

Astrocytes differentiation is modulated by the NF-KB pathway

(Submitter supplied) We demonstrate that persistent NF-KB activation affects neural progenitor cells-derived astrocytes differentiation
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
26 Samples
Download data: CEL
Series
Accession:
GSE117736
ID:
200117736
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