GEO DataSets

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6333

8 Samples

Download data

(Submitter supplied) RNA extracted from plasma cells purified from spleens were examined by Illumina microarray for gene expression. This was correlated with location and stage of differentiation using Blimp1 expression as a divider. All plasma cell samples were then compared to resting follicular B cells.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6333

4 Samples

Download data: TXT

(Submitter supplied) In vitro generated blasts from B cells deficient in prdm1 were isolated according to whether they were attempting to express Blimp1, reported by a GFP cassette knocked into the prdm1 locus

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6333

4 Samples

Download data: TXT

(Submitter supplied) Microarray expression arrays on mesothelium and other tissues dissected from mice were used to identify candidate mesothelial lineage markers. These were then tested by qRTPCR across a panel of human mesothelioma cells lines, other cancers, and normal primary cells includidng mesothelial cells.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6333

24 Samples

Download data: TXT

(Submitter supplied) In conjunction with other techniques, the role of caveolin-1 in lipid metabolism was assayed by comparing the gene expression of three tissues in Cav1+/+ and Cav1-/- mice. The tissues assayed were liver, adipose tissue, and mouse embryonic fibroblasts (MEFs) primary cell line, collected 24 hours after plating. The MEFs were selected to give insights into the fundamental cellular functions of Cav1. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6333

18 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by array

Datasets:

GDS3620 GDS3621

Platforms:

GPL6333 GPL1261

36 Samples

Download data: CEL

(Submitter supplied) Evaluation of transcriptional changes in the striatum may be an effective approach to understanding the natural history of changes in expression contributing to the pathogenesis of Huntington disease (HD). We have performed genome-wide expression profiling of the YAC128 transgenic mouse model of HD at 12 and 24 months of age using two platforms in parallel; Affymetrix and Illumina. We performed gene expression profiling on the same striatal mRNA across both platforms. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6333

18 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens; Mus musculus

Type:

Expression profiling by array

Platforms:

GPL6333 GPL2507

36 Samples

Download data

(Submitter supplied) Neurofibromatosis type 1 (NF1) is a common monogenic tumor-predisposition disorder that arises secondary to mutations in the tumor suppressor gene NF1. Haploinsufficiency of NF1 fosters a permissive tumorigenic environment through changes in signalling between cells; however, the intracellular mechanisms for this tumor-promoting effect are less clear. We hypothesized that the genetic effects of NF1-haploinsufficiency may be discerned by comparison of genome-wide transcriptional profiling in somatic, non-tumor cells from NF1-affected and –unaffected individuals. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6333

12 Samples

Download data: TXT

(Submitter supplied) The histone H3 lysine 9 (H3K9) methyltransferase Eset is an epigenetic regulator critical for the development of the inner cell mass (ICM). Although ICM-derived embryonic stem (ES) cells are normally unable to contribute to the trophectoderm (TE) in blastocysts, we find that depletion of Eset by shRNAs leads to differentiation with the formation of trophoblast-like cells and induction of trophoblast-associated gene expression. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3599

Platform:

GPL6333

6 Samples

Download data: TXT

(Submitter supplied) Acquisition of independence from anchorage to the extracellular matrix is a critical event for onset and progression of solid cancers. To identify and characterize new genes conferring anchorage independence, we transduced MCF10A human normal breast cells with a retroviral cDNA expression library and selected them by growth in suspension. Microarray analysis targeted on library-derived transcripts revealed robust and reproducible enrichment, after selection, of cDNAs encoding the scaffolding adaptor Gab2. more...

Organism:

Homo sapiens; Mus musculus

Type:

Expression profiling by array

Platforms:

GPL6333 GPL6106

20 Samples

Download data: XLS

(Submitter supplied) Mastic oil from Pistacia lentiscus variation chia, a blend of bioactive terpenes with recognized medicinal properties, has been recently shown to exert anti-tumor activity. Lewis lung carcinoma (LLC) cells are mastic oil-susceptible cells and were used in this work to study the effects of mastic oil at the transcriptomic level.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6333

40 Samples

Download data: TXT

(Submitter supplied) Systemic administration of β-adrenoceptor (β-AR) agonists has been found to induce skeletal muscle hypertrophy and significant metabolic changes. In the context of energy homeostasis, the importance of β-AR signaling has been highlighted by the inability of β1–3-AR-deficient mice to regulate energy expenditure and susceptibility to diet induced obesity. However, the molecular pathways and gene expression changes that initiate and maintain these phenotypic modulations are poorly understood. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6333

16 Samples

Download data: TXT

(Submitter supplied) Background Systematic search for genes whose gain-of-function by exogenous expression confers an advantage in cell-based selective screenings is a powerful method for unbiased functional exploration of the genome, and has the potential to disclose new targets for cancer therapy. A major limit of this approach resides in the labor-intensive cloning of resistant cells, identification of the integrated genes and validation of their ability to confer a selective advantage. more...

Organism:

Canis lupus familiaris; Mus musculus

Type:

Expression profiling by array

Platform:

GPL6333

7 Samples

Download data

(Submitter supplied) Disruption of the Circadian Clock within the Cardiomyocyte Influences Myocardial Contractie Function, Metabolism, and Gene Expression Virtually every mammalian cell, including cardiomyocytes, possesses an intrinsic circadian clock. The role of this transcriptionally-based molecular mechanism in cardiovascular biology is poorly understood. We hypothesized that the circadian clock within the cardiomyocyte influences diurnal variations in myocardial biology. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6333

130 Samples

Download data: XLS