GSE112140[Accession] - GEO DataSets

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Items: 6

Select item 2001121401.

Comparative hepatic transcriptome analyses revealed possible pathogenic mechanisms of fasiglifam (TAK-875)-induced acute liver injury in mice

(Submitter supplied) Fasiglifam (TAK-875), a G protein-coupled receptor 40 (GPR40) agonist, was a drug candidate for type 2 diabetes. However, its development was terminated in phase 3 trials due to liver safety concerns. Although TAK-875 was reported to inhibit hepatobiliary transporters and disturb bile acid disposition, pathogenic mechanisms of TAK-875-induced liver injury are not fully understood. In this study, we sought to identify the mechanisms with a hepatic genome-wide transcriptomic analysis in a murine model. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL21163
4 Samples

Download data: TXT

Series

Accession:: GSE112140

ID:: 200112140

Select item 1000211632.

Agilent-074809 SurePrint G3 Mouse GE v2 8x60K Microarray [Probe Name version]

(Submitter supplied) Catalog gene expression microarray for Mouse, v2 8x60K Arrays of this design have barcodes that begin with 16074809 or 2574809. Orientation: Features are numbered numbered Left-to-Right, Top-to-Bottom as scanned by an Agilent scanner (barcode on the left, DNA on the back surface, scanned through the glass), matching the FeatureNum output from Agilent's Feature Extraction software. The ID column represents the Agilent Probe Name. more...