GSE189478[Accession] - GEO DataSets

Select item 2001894781.

Differentially expressed genes induced by TPA stimulation between the P2ry6+/+ and P2ry6-/- mice

(Submitter supplied) We report that P2ry6-deficient mice exhibit marked resistance to 7,12-dimethylbenzanthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA)-induced two-stage skin papilloma formation compared with wild-type mice. Consistent with these findings, epidermal hyperplasia in response to TPA stimulation was suppressed in the P2ry6 knockout or MRS2578 (P2RY6 antagonist)-treated mice. The dramatic decrease in hyperplasia and tumorigenesis due to P2ry6 disruption was associated with the suppression of TPA-induced keratinocyte proliferation and inflammatory reactions.We have employed whole genome microarray expression profiling as a discovery platform to identify genes with the potential to distinguish differentially expressed genes induced by TPA stimulation between the P2ry6+/+ and P2ry6-/- mice. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL21163
6 Samples

Download data: TXT

Series

Accession:: GSE189478

ID:: 200189478

Analyze with GEO2R

Select item 1000211632.

Agilent-074809 SurePrint G3 Mouse GE v2 8x60K Microarray [Probe Name version]

(Submitter supplied) Catalog gene expression microarray for Mouse, v2 8x60K Arrays of this design have barcodes that begin with 16074809 or 2574809. Orientation: Features are numbered numbered Left-to-Right, Top-to-Bottom as scanned by an Agilent scanner (barcode on the left, DNA on the back surface, scanned through the glass), matching the FeatureNum output from Agilent's Feature Extraction software. The ID column represents the Agilent Probe Name. more...