GSM1083049[Accession] - GEO DataSets

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Items: 3

Select item 2000443191.

The E3 ubiquitin ligase Siah2 contributes to castration-resistant prostate cancer by regulation of androgen receptor transcriptional activity cancer.

(Submitter supplied) The androgen receptor (AR) plays a central role in the development of castration resistant prostate cancer (CRPC). Here, we demonstrate that the ubiquitin ligase Siah2 targets a select pool of NCOR1-bound, transcriptionally inactive AR for ubiquitination dependent degradation, thereby promoting the expression of ~13% of AR target genes. The Siah2 binding sites located within the AR ligand-binding domain are mutated in PCa, resulting in attenuation of Siah2-mediated regulation. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL16604
52 Samples

Download data: TXT

Series

Accession:: GSE44319

ID:: 200044319

Analyze with GEO2R

Select item 1000166042.

Agilent-032034 VPC Human 180K v3 (Probe Name version)

(Submitter supplied) annotation from RefSeq and EntrezGene Database (downloaded: April, 2012) Protocol: SurePrint G3 4x180K format, feature and microarray designed using eArray