GSM1296048[Accession] - GEO DataSets

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Items: 4

Select item 2000535521.

Gene expression profiling in psoriatic lesional and non-lesional skin [brodalumab treatment]

(Submitter supplied) To explore the psoriasis phenotype and pathways involved in psoriasis, we characterized gene expression in lesional and non-lesional skin from psoriasis patients. Furthermore, we explored the effects of various doses of brodalumab on lesional skin over time.

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS5420
Platform:: GPL570
99 Samples

Download data: CEL

Series

Accession:: GSE53552

ID:: 200053552

Select item 54202.

Psoriasis response to brodalumab: dose response and time course

Analysis of non-lesional and lesional psoriatic skins for up to 43 days following treatment with various doses of brodalumab, a human IgG2 mAb that selectively binds and blocks signaling through IL-17RA. Results provide insight into the molecular effect of blocking IL-17 signaling in psoriatic skin.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 3 agent, 4 dose, 25 individual, 4 time, 2 tissue sets

Platform:: GPL570
Series:: GSE53552
99 Samples

Download data: CEL

DataSet

Accession:: GDS5420

ID:: 5420

Select item 1000005703.

[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://0-www-ncbi-nlm-nih-gov.brum.beds.ac.uk/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 06, 2012: annotation table updated with netaffx build 32 June 23, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site Complete coverage of the Human Genome U133 Set plus 6,500 additional genes for analysis of over 47,000 transcripts All probe sets represented on the GeneChip Human Genome U133 Set are identically replicated on the GeneChip Human Genome U133 Plus 2.0 Array. more...