GEO DataSets

(Submitter supplied) Autosomal trisomies and monosomies bring serious threats to embryonic development through transcriptional disarray primarily caused by the dosage effect of the aneuploid part of the genome. The present study compared the effect of a mouse viable 30 Mb segmental trisomy on the genome-wide transcriptional profile of somatic (liver) cells and male germ cells. While the 1.6-fold change in expression of triplicated genes reflected the gene dosage in liver cells, the extra copy was almost fully compensated in early pachytene spermatocytes, showing 1.18-fold increase. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL7546

22 Samples

Download data: CEL

(Submitter supplied) CDF file was created by Microarray Lab at the Molecular and Behavioral Neuroscience Institute at the University of Michigan. Oligonucleotide probes on GeneChips were reorganized based on the latest genome and transcriptome information. In this particular case the Entrez Gene database (build: Jun 28, 2007) was used as source. For the CDF file based on Entrez Gene: A probe must hit only one genomic location; Probes that can be mapped to the same target sequence in the correct direction are grouped together in the same probe set; Each probe set must contain at least three oligonucleotide probes and probes in a set are ordered according to their location in the corresponding exon. more...

Organism:

Mus musculus

2 DataSets

16 Series

1 Related Platform

295 Samples

Download data: TAR