GSM1501748[Accession] - GEO DataSets

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Items: 4

Select item 2000612961.

b-Catenin Mediates the Development of Behavioral Resilience

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing

Platform:: GPL17021
55 Samples

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Series

Accession:: GSE61296

ID:: 200061296

PubMed Full text in PMC Similar studies

Select item 2000612952.

b-Catenin Mediates the Development of Behavioral Resilience [smallRNA-Seq]

(Submitter supplied) Here we show that β-catenin mediates pro-resilient and anxiolytic effects in mice in the nucleus accumbens (NAc), a key brain reward region, an effect that is mediated by β-catenin signaling in D2-type medium spiny neurons (MSNs) specifically. Conversely, blocking β-catenin function in NAc promotes susceptibility to chronic stress, and we show evidence of robust suppression of β-catenin transcriptional activity in the NAc both of depressed humans examined postmortem as well as of mice that display a susceptible phenotype after chronic stress, with a converse upregulation in mice that are stress resilient. more...