GSM1575186[Accession] - GEO DataSets

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Items: 3

Select item 2000580441.

mTORC1-mediated growth of kidney cysts is rapidly bypassed by other signaling pathways

(Submitter supplied) Cystic kidney disease (CyKD) is the leading monogenetic cause of endstage renal disease. In both mice and humans CyKD has been consistently linked to the activation of the mTORC1 pathway. Yet, the utility of mTORC1 inhibitors in CyKD patients remains controversial despite promising preclinical data. To conclusively define the cell intrinsic role of mTORC1 for cyst development, mTORC1 was selectively inactivated in renal tubular cells of an aciliary mouse model of CyKD by deleting the decisive scaffolding protein RAPTOR. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL19559
142 Samples

Download data: CEL

Series

Accession:: GSE58044

ID:: 200058044

Analyze with GEO2R

Select item 1000195592.

[Mouse4302_Mm_EntrezG] Affymetrix GeneChip Mouse Genome 430 2.0 Array [Mouse4302_Mm_ENTREZG_18.0.0]

(Submitter supplied) This is identical to GPL1261 but a custom CDF environment was used to extract data [Brainarray Version 18, Mouse4302_Mm_ENTREZG_18.0.0].