GSM225349[Accession] - GEO DataSets

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Items: 4

Select item 2000089211.

Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response

(Submitter supplied) In innate immune responses, activation of Toll-like receptors (TLRs) triggers direct antimicrobial activity against intracellular bacteria, which in murine, but not human, monocytes and macrophages is mediated principally by nitric oxide. We report here that TLR activation of human macrophages up-regulated expression of the vitamin D receptor and the vitamin D-1-hydroxylase genes, leading to induction of the antimicrobial peptide cathelicidin and killing of intracellular Mycobacterium tuberculosis. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS2954
Platform:: GPL96
50 Samples

Download data: CEL, EXP

Series

Accession:: GSE8921

ID:: 200008921

Select item 29542.

Mycobacterium tuberculosis-derived lipopeptide effect on monocytes and dendritic cells: time course

Analysis of monocytes (MOs) and MO-derived dendritic cells (DCs) for up to 24 hours following Mycobacterium tuberculosis-derived lipopeptide treatment. Toll-like receptor activation by bacterial lipopeptides reduced the viability of M. tuberculosis in MOs and macrophages but not MO-derived DCs.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 2 agent, 2 cell type, 15 individual, 5 time sets

Platform:: GPL96
Series:: GSE8921
50 Samples

Download data: CEL, EXP

DataSet

Accession:: GDS2954

ID:: 2954

Select item 1000000963.

[HG-U133A] Affymetrix Human Genome U133A Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://0-www-ncbi-nlm-nih-gov.brum.beds.ac.uk/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 08, 2012: annotation table updated with netaffx build 32 June 24, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site The U133 set includes 2 arrays with a total of 44928 entries and was indexed 29-Jan-2002. more...