GEO DataSets

(Submitter supplied) Mutations in PfCRT confer chloroquine (CQ) resistance in P. falciparum. Point mutations in the homolog of the mammalian multidrug resistance gene (pfmdr1) can also modulate the levels of CQ response. However, parasites with the same pfcrt and pfmdr1 alleles exhibit a wide range of drug sensitivity, suggesting that additional genes contribute to levels of CQ resistance (CQR). We used 3 isogenic lines which have different drug resistance profiles corresponding to unique mutations in the pfcrt gene (106/1K76, 106/176I, and 106/76I-352K) to study changes in gene expression with and without CQ and genomic variations, i.e. more...

Organism:

Plasmodium falciparum; Anopheles gambiae

Type:

Expression profiling by array; Genome variation profiling by array

Dataset:

GDS3284

Platform:

GPL1321

24 Samples

Download data: CEL

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://0-www-ncbi-nlm-nih-gov.brum.beds.ac.uk/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 Oct 12, 2009: annotation table updated with netaffx build 32 Protocol: see manufacturer's web site The GeneChip Plasmodium/Anopheles Genome Array includes probe sets to over 4,300 Plasmodium falciparam transcripts and approximately 14,900 Anopheles gambiae transcripts. more...

Organism:

Plasmodium falciparum; Anopheles gambiae

6 DataSets

30 Series

523 Samples

Download data