GSM593770[Accession] - GEO DataSets

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Items: 4

Select item 2000326411.

Major functional transcriptome of an inferred center regulator of an ER(-) breast cancer model system

(Submitter supplied) We aimed to find clinically relevant gene activities ruled by the signal transducer and activator of transcription 3 (STAT3) proteins in an ER(-) breast cancer population via network approach. STAT3 is negatively associated with both lymph nodal category and stage. MYC is a component of STAT3 network. MYC and STAT3 may co-regulate gene expressions for Warburg effect, stem cell like phenotype, cell proliferation and angiogenesis. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL887
102 Samples

Download data: TXT

Series

Accession:: GSE32641

ID:: 200032641

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000241242.

The inferred mechanisms for prognostic features of signal transducer and activator of transcription 3 in an ER(+) breast cancer model system

(Submitter supplied) Abstract Aberrantly expressed signal transducer and activator of transcription 3 (STAT3) predicts poor prognosis primarily in estrogen receptor positive (ER(+)) breast cancers and activated STAT3 is overexpressed in luminal A subtype cells. The mechanisms contributing to the prognosis and/or subtype relevant features of *STAT3* in ER(+) breast cancers are* *through multiple interacting regulatory pathways including STAT3-MYC, STAT3-ER , STAT3-MYC-ER interactions and the direct action of activated STAT3. more...

Organism:: Homo sapiens

Type:: Expression profiling by array; Third-party reanalysis

Platform:: GPL887
119 Samples

Download data: TXT

Series

Accession:: GSE24124

ID:: 200024124

PubMed Full text in PMC Similar studies

Select item 1000008873.

Agilent-012097 Human 1A Microarray (V2) G4110B (Feature Number version)

(Submitter supplied) Agilent's Human 1A Oligo Microarray (V2) includes over 20K 60-mer oligonucleotide probes, sourced from the Incyte Foundation Database, RefSeq, and GenBank, and are designed to span conserved exons across the transcripts of the targeted full length genes. Coupled with Agilent's probe selection and validation processes, this design method gives the customer maximum confidence in data quality and prevents redundancy in gene coverage. more...