GEO DataSets

(Submitter supplied) The response of drosophila to bacterial and fungal infections involves two signaling pathways, Toll and Imd, which both activate NF-kB family members. We have studied the global transcriptional response of flies to infection with drosophila C virus. Viral infection induced a set of genes distinct from those regulated by the Toll or Imd pathways, and triggered activation of a STAT binding activity. Genetic experiments showed that the JAK kinase Hopscotch was involved in the control of the viral load in infected flies, and was required, though not sufficient, for the induction of some virus-regulated genes. more...

Organism:

Drosophila melanogaster

Type:

Expression profiling by array

Dataset:

GDS1395

Platform:

GPL72

12 Samples

Download data: CEL, EXP

Expression profiling of Oregon R males 24 and 48 hours after drosophila C virus infection. Results provide insight into the response of the innate immune system to viral infections.

Organism:

Drosophila melanogaster

Type:

Expression profiling by array, transformed count, 2 infection, 2 time sets

Platform:

GPL72

Series:

GSE2828

12 Samples

Download data: CEL, EXP

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://0-www-ncbi-nlm-nih-gov.brum.beds.ac.uk/projects/geo/info/geo_affy.html Has 14010 entries and was indexed 29-Jan-2002 The sequences used to develop this array are accessible through FlyBase. Probes were synthesized in situ. Contains >13,500 gene sequences predicted from annotation of the Drosophila genome version 1, >8000 sequences for which confirming EST or full-length cDNA evidence is available, ~3,000 genes identified using prediction algorithms, and ~2,500 genes that not only have a gene predicted algorithmically, but also show some homology to genes from other organisms. more...

Organism:

Drosophila melanogaster

37 DataSets

111 Series

1233 Samples

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