GSM624965[Accession] - GEO DataSets

Warning: The NCBI web site requires JavaScript to function. more...

Format

Summary
Summary (text)
Unique Identifier List

Sort by

Default order
Number of Samples (High to Low)
Number of Samples (Low to High)

Send to:

Choose Destination

File
Clipboard
Collections

Search results

Items: 4

Select item 2000254621.

Increased SRF Transcriptional Activity is a Novel Signature of Insulin Resistance in Humans and Mice

(Submitter supplied) Insulin resistance in skeletal muscle is a key phenotype associated with type 2 diabetes (T2D) and is even present in offspring of diabetic parents. However, molecular mediators of insulin resistance remain unclear. We find that the top-ranking gene set in expression analysis of muscle from humans with T2D and normoglycemic insulin resistant subjects with parental family history (FH+) of T2D is increased expression of actin cytoskeleton genes regulated by serum response factor (SRF) and its coactivator MKL1. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS3884
Platform:: GPL570
50 Samples

Download data: CEL

Series

Accession:: GSE25462

ID:: 200025462

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 38842.

Type 2 diabetic and insulin-resistant but normoglycemic cohorts: skeletal muscle

Analysis of quadriceps muscle from type 2 diabetes (T2D) patients and from normoglycemic but insulin-resistant subjects with a parental family history of T2D. Insulin resistance in skeletal muscle is a key phenotype of T2D. Results provide insight into the molecular basis of this insulin resistance.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 3 disease state, 2 gender sets

Platform:: GPL570
Series:: GSE25462
50 Samples

Download data: CEL

DataSet

Accession:: GDS3884

ID:: 3884

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 1000005703.

[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://0-www-ncbi-nlm-nih-gov.brum.beds.ac.uk/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 06, 2012: annotation table updated with netaffx build 32 June 23, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site Complete coverage of the Human Genome U133 Set plus 6,500 additional genes for analysis of over 47,000 transcripts All probe sets represented on the GeneChip Human Genome U133 Set are identically replicated on the GeneChip Human Genome U133 Plus 2.0 Array. more...