GSM7102944[Accession] - GEO DataSets

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Items: 4

Select item 2002275701.

Transcriptome-based chemical screens identify CDK8 as a common barrier in multiple cell reprogramming systems

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL24247 GPL21273
19 Samples

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Series

Accession:: GSE227570

ID:: 200227570

PubMed Similar studies

Select item 2002275692.

Transcriptome-based chemical screens identify CDK8 as a common barrier in multiple cell reprogramming systems [RNA-seq]

(Submitter supplied) Fibroblasts can be chemically induced to pluripotent stem cells (CiPSCs) through an extraembryonic endoderm (XEN)-like state or directly converted into other differentiated cell lineages. However, the mechanisms underlying chemically-induced cell fate reprogramming remain unclear. Here, a transcriptome-based screen of biologically active compounds uncovered that CDK8 inhibition was essential to enable chemically-induced reprogramming from fibroblasts into XEN-like cells, then CiPSCs. more...